4JOL: Protein CBFA2T1

Complex structure of AML1-ETO NHR2 domain with HEB fragment. Determined by X-ray diffraction at 2.91 Å resolution. Released 26 Jun 2013.

Method
X-ray diffraction
Resolution
2.91 Å
Organism
Homo sapiens
Chains
8
Atoms
2,425
Mol. weight
42.63 kDa
Released
26 Jun 2013

Explore 4JOL in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4JOL contains 4 α-helices and 0 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and B: 1 helix, 0 β-strands

ElementResiduesLengthSheet
α-helix495-54551
Chains C and D: 1 helix, 0 β-strands
ElementResiduesLengthSheet
α-helix495-54652

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Protein CBFA2T1A, B, C, Dprotein64Homo sapiensQ06455 (AlphaFold model)
Transcription factor 12E, F, G, Hprotein25Homo sapiensQ99081 (AlphaFold model)
Sequence of entity 1 (A, B, C, D), FASTA
>4JOL_1 Protein CBFA2T1 (chains A, B, C, D)
SEEMIDHRLTDREWAEEWKHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRY
SDAE
Sequence of entity 2 (E, F, G, H), FASTA
>4JOL_2 Transcription factor 12 (chains E, F, G, H)
SPLQAKKVRKVPPGLPSSVYAPSPN

Primary citation

A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis. Sun, X.J., Wang, Z., Wang, L. et al. Nature (2013) 500:93-97. DOI 10.1038/nature12287 · PubMed

Other PDB entries of the same protein (UniProt Q06455 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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