4MLP: Mammalian cryptochrome

Mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase. Determined by X-ray diffraction at 1.94 Å resolution. Released 16 Oct 2013.

Method

X-ray diffraction

Resolution

1.94 Å

Organism

Mus musculus

Chains

4

Atoms

17,726

Mol. weight

236.35 kDa

Ligands

2CX

Released

16 Oct 2013

Explore 4MLP in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4MLP contains 149 α-helices and 37 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 37 helices, 9 β-strands

Molecules and chains

>4MLP_1 Cryptochrome-2 (chains A, B, C, D)
MAAAAVVAATVPAQSMGADGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFA
ASSSVGINRWRFLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFKEWGVTRLTFEYDS
EPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDRIIELNGQKPPLTYKRFQALISRMEL
PKKPAVAVSSQQMESCRAEIQENHDDTYGVPSLEELGFPTEGLGPAVWQGGETEALARLD
KHLERKAWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKKVKRNSTP
PLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDA
IMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVRVFDELLLDADFSVNAGSWMWLSC
SAFFQQFFHCYCPVGFGRRTDPSGDYIRRYLPKLKGFPSRYIYEPWNAPESVQKAAKCII
GVDYPRPIVNHAETSRLNIERMKQIYQQLSRY

Ligands and cofactors

Primary citation

Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase. Nangle, S., Xing, W., Zheng, N. Cell Res (2013) 23:1417-1419. DOI 10.1038/cr.2013.136 · PubMed

Related structures

Other PDB entries of the same protein (UniProt Q9R194 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 7V8Y 1.9 Å, Crystal structure of mouse CRY2 in complex with SHP1703 compound
• 7V8Z 1.95 Å, Crystal structure of mouse CRY2 in complex with SHP656 compound
• 4I6G 2.2 Å, a vertebrate cryptochrome with FAD
• 6KX8 2.25 Å, Crystal structure of mouse Cryptochrome 2 in complex with TH301 compound
• 7EJ9 2.6 Å, Alternative crystal structure of mouse Cryptochrome 2 in complex with TH301 compound
• 4I6E 2.7 Å, A vertebrate cryptochrome
• 4I6J 2.7 Å, A ubiquitin ligase-substrate complex
• 4U8H 2.8 Å, Crystal Structure of Mammalian Period-Cryptochrome Complex
• 7D0N 2.8 Å, Crystal structure of mouse CRY2 apo form

Browse structure collections

About this viewer

MolViewer shows 4MLP directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.