Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule. Determined by X-ray diffraction at 1.12 Å resolution. Released 30 Apr 2014.
Explore 4MRH in 3D Show helices and sheets RCSB PDB PDBe
4MRH contains 7 α-helices and 15 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 25-30 | 6 | 1 |
| β-strand | 33-34 | 2 | 1 |
| β-strand | 37-42 | 6 | 1 |
| β-strand | 48 | 1 | 2 |
| α-helix | 50-59 | 10 | |
| β-strand | 63 | 1 | 1 |
| α-helix | 64-66 | 3 | |
| α-helix | 67-75 | 9 | |
| β-strand | 84-85 | 2 | 1 |
| β-strand | 90-94 | 5 | 1 |
| β-strand | 98 | 1 | 3 |
| β-strand | 101 | 1 | 3 |
| α-helix | 102-104 | 3 | |
| β-strand | 107-110 | 4 | 1 |
| α-helix | 111 | 1 | |
| β-strand | 119 | 1 | 2 |
| β-strand | 120-124 | 5 | 1 |
| β-strand | 132-133 | 2 | 1 |
| α-helix | 136-137 | 2 | |
| β-strand | 144-154 | 11 | 1 |
| β-strand | 159-165 | 7 | 1 |
| α-helix | 170-172 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| CD44 antigen | A | protein | 150 | Mus musculus | P15379 (AlphaFold model) |
>4MRH_1 CD44 antigen (chains A) NQIDLNVTCRYAGVFHVEKNGRYSISRTEAADLCQAFNSTLPTMDQMKLALSKGFETCRY GFIEGNVVIPRIHPNAICAANHTGVYILVTSNTSHYDTYCFNASAPPEEDCTSVTDLPNS FDGPVTITIVNRDGTRYSKKGEYRTHQEDI
| ID | Name | Formula | Copies |
|---|---|---|---|
| 2CQ | 4-chloro-5-methylbenzene-1,2-diamine | C7 H9 Cl N2 | 1 |
Water and common crystallization additives (DMS) are not listed.
Fragment-Based Identification of an Inducible Binding Site on Cell Surface Receptor CD44 for the Design of Protein-Carbohydrate Interaction Inhibitors. Liu, L.K., Finzel, B.C. J Med Chem (2014) 57:2714-2725. DOI 10.1021/jm5000276 · PubMed
Other PDB entries of the same protein (UniProt P15379 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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