Crystal structure of human calcineurin. Determined by X-ray diffraction at 2.23 Å resolution. Released 20 May 2015.
Explore 4OR9 in 3D Show helices and sheets RCSB PDB PDBe
4OR9 contains 35 α-helices and 26 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 16-20 | 5 | |
| α-helix | 31-34 | 4 | |
| α-helix | 37 | 1 | |
| β-strand | 38 | 1 | 1 |
| α-helix | 39 | 1 | |
| α-helix | 40-43 | 4 | |
| β-strand | 44 | 1 | 2 |
| β-strand | 50 | 1 | 2 |
| α-helix | 52-60 | 9 | |
| β-strand | 65 | 1 | 1 |
| α-helix | 67-82 | 16 | |
| β-strand | 87-90 | 4 | 3 |
| β-strand | 94-97 | 4 | 4 |
| β-strand | 99 | 1 | 5 |
| α-helix | 104-114 | 11 | |
| β-strand | 122-124 | 3 | 4 |
| α-helix | 135-148 | 14 | |
| β-strand | 153-155 | 3 | 4 |
| α-helix | 163-168 | 6 | |
| α-helix | 171-178 | 8 | |
| α-helix | 181-192 | 12 | |
| β-strand | 197-200 | 4 | 3 |
| β-strand | 204-207 | 4 | 3 |
| α-helix | 218-222 | 5 | |
| α-helix | 229-231 | 3 | |
| α-helix | 235-241 | 7 | |
| β-strand | 243-244 | 2 | 6 |
| β-strand | 257-259 | 3 | 6 |
| β-strand | 267-269 | 3 | 6 |
| α-helix | 271-281 | 11 | |
| β-strand | 285-288 | 4 | 3 |
| β-strand | 297-299 | 3 | 3 |
| α-helix | 301 | 1 | |
| β-strand | 302 | 1 | 7 |
| α-helix | 303 | 1 | |
| β-strand | 309 | 1 | 7 |
| β-strand | 311-314 | 4 | 3 |
| β-strand | 315 | 1 | 5 |
| α-helix | 320-322 | 3 | |
| β-strand | 328-334 | 7 | 4 |
| β-strand | 337-343 | 7 | 4 |
| α-helix | 353-355 | 3 | |
| α-helix | 358-378 | 21 | |
| α-helix | 479-485 | 7 | |
| α-helix | 488-490 | 3 | |
| α-helix | 492-494 | 3 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 5-8 | 4 | |
| α-helix | 16-29 | 14 | |
| β-strand | 36-37 | 2 | 8 |
| α-helix | 39-42 | 4 | |
| α-helix | 46-48 | 3 | |
| α-helix | 54-61 | 8 | |
| β-strand | 69-70 | 2 | 8 |
| α-helix | 71-79 | 9 | |
| α-helix | 87-98 | 12 | |
| β-strand | 105-106 | 2 | 9 |
| α-helix | 108-119 | 12 | |
| α-helix | 125-139 | 15 | |
| β-strand | 147-148 | 2 | 9 |
| α-helix | 149-156 | 8 | |
| α-helix | 161-163 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform | A | protein | 544 | Homo sapiens | P16298 (AlphaFold model) |
| Calcineurin subunit B type 1 | B | protein | 170 | Homo sapiens | P63098 (AlphaFold model) |
>4OR9_1 Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (chains A) MGSSHHHHHHSSGLVPRGSHMAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTS EEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDI HGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNH ECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDD IRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQN NNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNI RQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDGSAAA RKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGGRQTLQSATVEA IEAEKAIRGFSPPHRICSFEEAKGLDRINERMPPRKDAVQQDGFNSLNTAHATENHGTGN HTAQ
>4OR9_2 Calcineurin subunit B type 1 (chains B) MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVID IFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMV GNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV
Cooperative autoinhibition and multi-level activation mechanisms of calcineurin. Li, S.J., Ma, L., Wang, J. et al. To be published.
Other PDB entries of the same protein (UniProt P16298 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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