4PES: Insulin degrading enzyme

Crystal structure of insulin degrading enzyme complexed with inhibitor tert-butyl [(2S)-2-(2,5-difluorophenyl)-3-(quinolin-3-yl)propyl]carbamate. Determined by X-ray diffraction at 2.21 Å resolution. Released 17 Jun 2015.

Method

X-ray diffraction

Resolution

2.21 Å

Organism

Homo sapiens

Chains

4

Atoms

16,206

Mol. weight

230.38 kDa

Ligands

2PJ, ZN

Released

17 Jun 2015

Explore 4PES in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4PES contains 117 α-helices and 70 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 59 helices, 34 β-strands

Molecules and chains

>4PES_1 Insulin-degrading enzyme (chains A, B)
MGHHHHHHGRAMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAAL
DVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYY
FDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGN
PKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNL
VVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNP
GHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDI
ILHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVL
TAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVI
KKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLP
KANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLS
VKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLM
TEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLI
EHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLEL
FAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITM
EKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKT
LTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSNPVVGEFPAQNDINLSQAPALPQPE
VIQNMTEFKRGLPLFPLVKPHINFMAAKL

>4PES_2 Ala-Ala-Ala (chains C, D)
AAA

Ligands and cofactors

Primary citation

Crystal structure of IDE complexed with an inhibitor. Durham, T.B., Toth, J.L., Klimkowski, V.J. et al. To be published.

Related structures

Other PDB entries of the same protein (UniProt P14735 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 3CWW 1.96 Å, Crystal Structure of IDE-bradykinin complex
• 2G47 2.1 Å, Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-40)
• 2G56 2.2 Å, crystal structure of human insulin-degrading enzyme in complex with insulin B chain
• 4PFC 2.21 Å, Crystal structure of insulin degrading enzyme complexed with inhibitor
• 2G54 2.25 Å, Crystal structure of Zn-bound human insulin-degrading enzyme in complex with insulin B…
• 3E4Z 2.28 Å, Crystal structure of human insulin degrading enzyme in complex with insulin-like growth…
• 3E50 2.3 Å, Crystal structure of human insulin degrading enzyme in complex with transforming growth…
• 4PF7 2.33 Å, Crystal structure of insulin degrading enzyme complexed with inhibitor
• 3OFI 2.35 Å, Crystal structure of human insulin-degrading enzyme in complex with ubiquitin
• 2G49 2.5 Å, Crystal structure of human insulin-degrading enzyme in complex with glucagon
• 4PF9 2.5 Å, Crystal structure of insulin degrading enzyme complexed with inhibitor
• 2WK3 2.59 Å, Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-42)

Browse structure collections

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