4PJW: Human Stromal Antigen 2

crystal structure of human Stromal Antigen 2 (SA2) in complex with Sister Chromatid Cohesion protein 1 (Scc1), with bound MES. Determined by X-ray diffraction at 2.85 Å resolution. Released 27 Aug 2014.

Method
X-ray diffraction
Resolution
2.85 Å
Organism
Homo sapiens
Chains
2
Atoms
8,000
Mol. weight
131.87 kDa
Released
27 Aug 2014

Explore 4PJW in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4PJW contains 58 α-helices and 8 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 54 helices, 4 β-strands

ElementResiduesLengthSheet
α-helix84-907
α-helix95-10814
α-helix110-12314
α-helix133-1386
α-helix141-15010
α-helix166-18419
α-helix190-1923
α-helix196-20712
β-strand21211
α-helix213-25341
α-helix261-28828
α-helix289-2935
α-helix294-2963
β-strand29912
α-helix302-31817
α-helix320-3234
α-helix326-33510
α-helix341-35212
α-helix362-37716
α-helix378-3803
β-strand38113
α-helix384-40017
α-helix407-4159
α-helix416-4183
β-strand41914
α-helix422-43615
α-helix458-47013
α-helix478-4847
α-helix489-4924
α-helix495-5017
α-helix515-53319
α-helix537-5382
α-helix550-57829
α-helix582-5887
α-helix591-5944
α-helix599-6024
α-helix606-62217
α-helix626-63914
α-helix647-67327
α-helix681-70020
α-helix709-72214
α-helix727-74620
α-helix756-77419
α-helix775-7773
α-helix781-79717
α-helix800-8023
α-helix819-83214
α-helix854-87320
α-helix879-8824
α-helix883-8864
α-helix893-90816
α-helix912-93423
α-helix943-95614
α-helix968-98114
α-helix999-10035
α-helix1012-102211
α-helix1028-10325
α-helix1039-10468
Chain B: 4 helices, 4 β-strands
ElementResiduesLengthSheet
β-strand32611
β-strand33112
α-helix334-3429
β-strand34813
β-strand35314
α-helix358-3669
α-helix369-3724
α-helix383-3908

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Cohesin subunit SA-2Aprotein981Homo sapiensQ8N3U4 (AlphaFold model)
Double-strand-break repair protein rad21 homologBprotein140Homo sapiensO60216 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>4PJW_1 Cohesin subunit SA-2 (chains A)
ENMMLFEVVKMGKSAMQSVVDDWIESYKHDRDIALLDLINFFIQCSGCKGVVTAEMFRHM
QNSEIIRKMTEEFDEDSGDYPLTMAGPQWKKFKSSFCEFIGVLVRQCQYSIIYDEYMMDT
VISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNLSINMDNTQRQYEAERNKMIGKR
ANERLELLLQKRKELQENQDEIENMMNAIFKGVFVHRYRDAIAEIRAICIEEIGIWMKMY
SDAFLNDSYLKYVGWTMHDKQGEVRLKCLTALQGLYYNKELNSKLELFTSRFKDRIVSMT
LDKEYDVAVQAIKLLTLVLQSSEEVLTAEDCENVYHLVYSAHRPVAVAAGEFLYKKLFSR
RDPEEDGMMKRRGRQGPNANLVKTLVFFFLESELHEHAAYLVDSMWDCATELLKDWECMN
SLLLEEPLSGEEALTDRQESALIEIMLCTIRQAAECHPPVGRGTGKRVLTAKEKKTQLDD
RTKITELFAVALPQLLAKYSVDAEKVTNLLQLPQYFDLEIYTTGRLEKHLDALLRQIRNI
VEKHTDTDVLEACSKTYHALCNEEFTIFNRVDISRSQLIDELADKFNRLLEDFLQEGEEP
DEDDAYQVLSTLKRITAFHNAHDLSKWDLFACNYKLLKTGIENGDMPEQIVIHALQCTHY
VILWQLAKITESSSTKEDLLRLKKQMRVFCQICQHYLTNVNTTVKEQAFTILCDILMIFS
HQIMSGGRDMLEPLVYTPDSSLQSELLSFILDHVFIEQDDDNNSADGQQEDEASKIEALH
KRRNLLAAFCKLIVYTVVEMNTAADIFKQYMKYYNDYGDIIKETMSKTRQIDKIQCAKTL
ILSLQQLFNEMIQENGYNFDRSSSTFSGIKELARRFALTFGLDQLKTREAIAMLHKDGIE
FAFKEPNPQGESHPPLNLAFLDILSEFSSKLLRQDKRTVYVYLEKFMTFQMSLRREDVWL
PLMSYRNSLLAGGDDDTMSVI
Sequence of entity 2 (B), FASTA
>4PJW_2 Double-strand-break repair protein rad21 homolog (chains B)
VDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLIVDSVKELDSKTIRAQ
LSDYSDIVTTLDLAPPTKKLMMWKETGGVEKLFSLPAQPLWNNRLLKLFTRCLTPLVPED
LRKRRKGGEADNLDEFLKEF

Primary citation

Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion. Hara, K., Zheng, G., Qu, Q. et al. Nat Struct Mol Biol (2014) 21:864-870. DOI 10.1038/nsmb.2880 · PubMed

Other PDB entries of the same protein (UniProt Q8N3U4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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