9HMV: SA2-SCC1 complex

Cryo-EM structure of SA2-SCC1 complex at 2.9 angstrom. Determined by electron microscopy at 2.9 Å resolution. Released 3 Sept 2025.

Method
Electron microscopy
Resolution
2.9 Å
Organism
Homo sapiens
Chains
2
Atoms
8,234
Mol. weight
173.42 kDa
Released
3 Sept 2025

Explore 9HMV in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9HMV contains 66 α-helices and 8 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 61 helices, 4 β-strands

ElementResiduesLengthSheet
α-helix84-907
α-helix95-10814
α-helix110-12314
α-helix133-1386
α-helix141-15010
α-helix166-18621
α-helix190-1923
α-helix196-20712
β-strand21211
α-helix213-25442
α-helix262-28827
α-helix289-2935
α-helix294-2963
β-strand29912
α-helix302-31817
α-helix320-3234
α-helix326-33510
α-helix341-35515
α-helix362-37918
β-strand38113
α-helix384-40017
α-helix407-4148
α-helix415-4184
β-strand41914
α-helix422-43211
α-helix433-4375
α-helix452-4543
α-helix458-47013
α-helix478-4836
α-helix489-4924
α-helix495-5039
α-helix505-5073
α-helix510-5145
α-helix515-53319
α-helix537-5382
α-helix550-57728
α-helix582-5887
α-helix591-5944
α-helix599-6024
α-helix606-62217
α-helix626-63914
α-helix647-67226
α-helix681-70020
α-helix709-72113
α-helix727-74822
α-helix755-77521
α-helix781-79717
α-helix800-8034
α-helix808-8136
α-helix816-8183
α-helix819-83214
α-helix853-87321
α-helix879-8824
α-helix883-8875
α-helix893-91018
α-helix912-93322
α-helix943-95715
α-helix967-98115
α-helix985-9862
α-helix993-9942
α-helix997-9993
α-helix1000-10034
α-helix1004-10085
α-helix1012-102413
α-helix1038-104912
Chain B: 5 helices, 4 β-strands
ElementResiduesLengthSheet
β-strand32611
β-strand33112
α-helix334-3429
α-helix345-3473
β-strand34813
β-strand35314
α-helix358-3669
α-helix369-3724
α-helix383-3908

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Cohesin subunit SA-2Aprotein1271Homo sapiensQ8N3U4 (AlphaFold model)
Double-strand-break repair protein rad21 homologBprotein241Homo sapiensO60216 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>9HMV_1 Cohesin subunit SA-2 (chains A)
MIAAPEIPTDFNLLQESETHFSSDTDFEDIEGKNQKQGKGKTCKKGKKGPAEKGKGGNGG
GKPPSGPNRMNGHHQQNGVENMMLFEVVKMGKSAMQSVVDDWIESYKHDRDIALLDLINF
FIQCSGCKGVVTAEMFRHMQNSEIIRKMTEEFDEDSGDYPLTMAGPQWKKFKSSFCEFIG
VLVRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNLSIN
MDNTQRQYEAERNKMIGKRANERLELLLQKRKELQENQDEIENMMNAIFKGVFVHRYRDA
IAEIRAICIEEIGIWMKMYSDAFLNDSYLKYVGWTMHDKQGEVRLKCLTALQGLYYNKEL
NSKLELFTSRFKDRIVSMTLDKEYDVAVQAIKLLTLVLQSSEEVLTAEDCENVYHLVYSA
HRPVAVAAGEFLYKKLFSRRDPEEDGMMKRRGRQGPNANLVKTLVFFFLESELHEHAAYL
VDSMWDCATELLKDWECMNSLLLEEPLSGEEALTDRQESALIEIMLCTIRQAAECHPPVG
RGTGKRVLTAKEKKTQLDDRTKITELFAVALPQLLAKYSVDAEKVTNLLQLPQYFDLEIY
TTGRLEKHLDALLRQIRNIVEKHTDTDVLEACSKTYHALCNEEFTIFNRVDISRSQLIDE
LADKFNRLLEDFLQEGEEPDEDDAYQVLSTLKRITAFHNAHDLSKWDLFACNYKLLKTGI
ENGDMPEQIVIHALQCTHYVILWQLAKITESSSTKEDLLRLKKQMRVFCQICQHYLTNVN
TTVKEQAFTILCDILMIFSHQIMSGGRDMLEPLVYTPDSSLQSELLSFILDHVFIEQDDD
NNSADGQQEDEASKIEALHKRRNLLAAFCKLIVYTVVEMNTAADIFKQYMKYYNDYGDII
KETMSKTRQIDKIQCAKTLILSLQQLFNEMIQENGYNFDRSSSTFSGIKELARRFALTFG
LDQLKTREAIAMLHKDGIEFAFKEPNPQGESHPPLNLAFLDILSEFSSKLLRQDKRTVYV
YLEKFMTFQMSLRREDVWLPLMSYRNSLLAGGDDDTMSVISGISSRGSTVRSKKSKPSTG
KRKVVEGMQLSLTEESSSSDSMWLSREQTLHTPVMMQTPQLTSTIMREPKRLRPEDSFMS
VYPMQTEHHQTPLDYNRRGTSLMEDDEEPIVEDVMMSSEGRIEDLNEGMDFDTMDIDLPP
SKNRRERTELKPDFFDPASIMDESVLGVSMFSSLAEENLYFQSWSHPQFEKGGGSGGGSG
GGSWSHPQFEK
Sequence of entity 2 (B), FASTA
>9HMV_2 Double-strand-break repair protein rad21 homolog (chains B)
DITVKETKAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKLMMWKETGGV
EKLFSLPAQPLWNNRLLKLFTRCLTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPRED
QQQQHQQRDVIDEPIIEEPSRLQESVMEASRTNIDESAMPPPPPQGVKRKAGQIDPEPVM
PPQQVEQMEIPPVELPPEEPPNICQLIPELELLPEKEKEKEKEKEDDEEEEDEDASGGDQ
D

Primary citation

Substrate recognition by human separase. Yu, J., Schmidt, S., Botto, M. et al. Sci Adv (2025) 11:eady9807-eady9807. DOI 10.1126/sciadv.ady9807 · PubMed

Other PDB entries of the same protein (UniProt Q8N3U4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

About this viewer

MolViewer shows 9HMV directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.