4Q2X: Arginyl-tRNA synthetase

Crystal structure of Arginyl-tRNA synthetase complexed with L-canavanine. Determined by X-ray diffraction at 2.8 Å resolution. Released 23 Jul 2014.

Method
X-ray diffraction
Resolution
2.8 Å
Organism
Homo sapiens
Chains
2
Atoms
9,578
Mol. weight
139.05 kDa
Ligands
GGB
Released
23 Jul 2014

Explore 4Q2X in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4Q2X contains 58 α-helices and 38 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 30 helices, 19 β-strands

ElementResiduesLengthSheet
α-helix4-1916
β-strand30-3231
β-strand41-4331
α-helix46-527
β-strand5512
β-strand5812
α-helix62-7110
β-strand79-8571
β-strand89-9461
α-helix96-10813
β-strand121-12553
α-helix1291
β-strand13014
α-helix137-15519
β-strand159-16463
β-strand16714
α-helix173-18311
α-helix197-21014
α-helix212-22615
α-helix230-25324
β-strand259-26023
α-helix263-2664
α-helix267-27812
β-strand283-28645
β-strand289-29245
α-helix3001
β-strand301-30445
α-helix312-32514
β-strand331-33773
α-helix338-3403
α-helix341-35313
β-strand363-36973
β-strand372-37326
β-strand37916
α-helix390-40516
α-helix409-4113
α-helix416-4172
α-helix418-4225
α-helix423-43614
β-strand444-44526
α-helix448-4514
α-helix459-47517
α-helix480-48910
α-helix490-4934
α-helix497-50610
α-helix509-51911
α-helix523-54018
α-helix556-5583
α-helix560-58021
Chain B: 28 helices, 19 β-strands
ElementResiduesLengthSheet
α-helix4-1916
β-strand29-3247
β-strand41-4447
α-helix46-538
α-helix62-7110
β-strand79-8577
β-strand89-9467
α-helix96-10813
β-strand121-12558
α-helix1291
β-strand13019
α-helix137-15418
β-strand159-16468
β-strand16719
α-helix173-18311
α-helix197-21014
α-helix212-22615
α-helix230-25324
β-strand259-26028
α-helix263-2664
α-helix267-27812
β-strand283-286410
β-strand289-292410
α-helix3001
β-strand301-304410
α-helix312-32514
β-strand331-33448
β-strand337111
α-helix338-3403
α-helix341-35313
β-strand363-36648
β-strand369111
β-strand372-373212
β-strand379112
α-helix387-3893
α-helix390-40516
α-helix416-4227
α-helix423-43614
β-strand444-445212
α-helix448-4514
α-helix459-47517
α-helix480-48910
α-helix490-4934
α-helix497-50610
α-helix509-51911
α-helix523-54018
α-helix560-58021

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Arginine--tRNA ligase, cytoplasmicA, Bprotein607Homo sapiensP54136 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>4Q2X_1 Arginine--tRNA ligase, cytoplasmic (chains A, B)
HHHHHHSSGLVPRGSHMASMINIISRLQEVFGHAIKAAYPDLENPPLLVTPSQQAKFGDY
QCNSAMGISQMLKTKEQKVNPREIAENITKHLPDNECIEKVEIAGPGFINVHLRKDFVSE
QLTSLLVNGVQLPALGENKKVIVDFSSPNIAKEMHVGHLRSTIIGESISRLFEFAGYDVL
RLNHVGDWGTQFGMLIAHLQDKFPDYLTVSPPIGDLQVFYKESKKRFDTEEEFKKRAYQC
VVLLQGKNPDITKAWKLICDVSRQELNKIYDALDVSLIERGESFYQDRMNDIVKEFEDRG
FVQVDDGRKIVFVPGCSIPLTIVKSDGGYTYDTSDLAAIKQRLFEEKADMIIYVVDNGQS
VHFQTIFAAAQMIGWYDPKVTRVFHAGFGVVLGEDKKKFKTRSGETVRLMDLLGEGLKRS
MDKLKEKERDKVLTAEELNAAQTSVAYGCIKYADLSRNRLNDYIFSFDKMLDDRGNTAAY
LLYAFTRIRSIARLANIDEEMLQKAARETKILLDHEKEWKLGRCILRFPEILQKILDDLF
LHTLCDYIYELATAFTEFYDSCYCVEKDRQTGKILKVNMWRMLLCEAVAAVMAKGFDILG
IKPVQRM

Ligands and cofactors

IDNameFormulaCopies
GGBL-canavanineC5 H12 N4 O32

Primary citation

The crystal structure of arginyl-tRNA synthetase from Homo sapiens. Kim, H.S., Cha, S.Y., Jo, C.H. et al. FEBS Lett (2014) 588:2328-2334. DOI 10.1016/j.febslet.2014.05.027 · PubMed

Other PDB entries of the same protein (UniProt P54136 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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