4Q2Y: Arginyl-tRNA synthetase

Crystal structure of Arginyl-tRNA synthetase. Determined by X-ray diffraction at 2.8 Å resolution. Released 23 Jul 2014.

Method
X-ray diffraction
Resolution
2.8 Å
Organism
Homo sapiens
Chains
2
Atoms
9,333
Mol. weight
138.7 kDa
Released
23 Jul 2014

Explore 4Q2Y in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4Q2Y contains 58 α-helices and 43 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 29 helices, 21 β-strands

ElementResiduesLengthSheet
α-helix4-1310
β-strand30-3231
β-strand41-4331
β-strand90-9231
α-helix93-953
α-helix96-10914
β-strand121-12552
α-helix1291
β-strand13013
α-helix134-1352
α-helix137-15519
β-strand159-16462
β-strand16713
α-helix172-18312
α-helix197-21014
α-helix212-22615
α-helix230-25324
β-strand259-26022
α-helix263-2664
α-helix267-27913
β-strand283-28644
β-strand289-29244
β-strand301-30444
β-strand31014
α-helix312-32110
α-helix322-3265
β-strand331-33442
β-strand33715
α-helix338-3403
α-helix341-35313
β-strand363-36642
β-strand36915
α-helix370-3712
β-strand372-37326
β-strand37916
α-helix390-40516
α-helix415-4162
α-helix417-4226
α-helix423-43614
β-strand444-44526
α-helix448-4525
α-helix459-46911
α-helix473-4764
α-helix480-48910
α-helix497-50610
α-helix509-51911
α-helix523-54018
β-strand547-54827
β-strand555-55737
α-helix560-57920
Chain B: 29 helices, 22 β-strands
ElementResiduesLengthSheet
α-helix4-1714
β-strand30-3238
α-helix36-383
β-strand41-4338
α-helix45-484
α-helix67-726
β-strand79-8248
β-strand90-9458
α-helix951
α-helix96-10914
β-strand121-12559
α-helix1291
β-strand130110
α-helix134-1352
α-helix137-15519
β-strand159-16469
β-strand167110
α-helix172-18312
α-helix197-20913
α-helix212-22615
α-helix230-25324
β-strand259-26029
α-helix263-2664
α-helix267-27913
β-strand283-286411
β-strand289-292411
β-strand301-304411
β-strand310111
α-helix312-32514
β-strand331-33449
β-strand337112
α-helix338-3403
α-helix341-35313
β-strand363-36649
β-strand369112
α-helix370-3712
β-strand372-373213
β-strand379113
α-helix390-40516
α-helix415-4195
α-helix421-43616
β-strand444-445213
α-helix448-4525
α-helix459-47416
α-helix480-48910
α-helix497-50610
α-helix509-51911
α-helix523-54018
β-strand546-548314
β-strand555-558414
α-helix560-57920

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Arginine--tRNA ligase, cytoplasmicA, Bprotein607Homo sapiensP54136 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>4Q2Y_1 Arginine--tRNA ligase, cytoplasmic (chains A, B)
HHHHHHSSGLVPRGSHMASMINIISRLQEVFGHAIKAAYPDLENPPLLVTPSQQAKFGDY
QCNSAMGISQMLKTKEQKVNPREIAENITKHLPDNECIEKVEIAGPGFINVHLRKDFVSE
QLTSLLVNGVQLPALGENKKVIVDFSSPNIAKEMHVGHLRSTIIGESISRLFEFAGYDVL
RLNHVGDWGTQFGMLIAHLQDKFPDYLTVSPPIGDLQVFYKESKKRFDTEEEFKKRAYQC
VVLLQGKNPDITKAWKLICDVSRQELNKIYDALDVSLIERGESFYQDRMNDIVKEFEDRG
FVQVDDGRKIVFVPGCSIPLTIVKSDGGYTYDTSDLAAIKQRLFEEKADMIIYVVDNGQS
VHFQTIFAAAQMIGWYDPKVTRVFHAGFGVVLGEDKKKFKTRSGETVRLMDLLGEGLKRS
MDKLKEKERDKVLTAEELNAAQTSVAYGCIKYADLSRNRLNDYIFSFDKMLDDRGNTAAY
LLYAFTRIRSIARLANIDEEMLQKAARETKILLDHEKEWKLGRCILRFPEILQKILDDLF
LHTLCDYIYELATAFTEFYDSCYCVEKDRQTGKILKVNMWRMLLCEAVAAVMAKGFDILG
IKPVQRM

Primary citation

The crystal structure of arginyl-tRNA synthetase from Homo sapiens. Kim, H.S., Cha, S.Y., Jo, C.H. et al. FEBS Lett (2014) 588:2328-2334. DOI 10.1016/j.febslet.2014.05.027 · PubMed

Other PDB entries of the same protein (UniProt P54136 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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