Crystal structure of the c-Src-SH3 domain in complex with the high affinity peptide VSL12. Determined by X-ray diffraction at 0.98 Å resolution. Released 28 Oct 2015.
Explore 4RTZ in 3D Show helices and sheets RCSB PDB PDBe
4RTZ contains 2 α-helices and 8 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 85-88 | 4 | 1 |
| β-strand | 92 | 1 | 2 |
| β-strand | 99 | 1 | 1 |
| β-strand | 102 | 1 | 2 |
| β-strand | 107-112 | 6 | 1 |
| β-strand | 118-123 | 6 | 1 |
| β-strand | 129-133 | 5 | 1 |
| α-helix | 134-136 | 3 | |
| β-strand | 137-139 | 3 | 1 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 7-11 | 5 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase Src | A | protein | 61 | Gallus gallus | P00523 (AlphaFold model) |
| VSL12 peptide | B | protein | 12 |
>4RTZ_1 Proto-oncogene tyrosine-protein kinase Src (chains A) GSHMTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLTTGQTGYIPSNYVAPS D
>4RTZ_2 VSL12 peptide (chains B) VSLARRPLPPLP
| ID | Name | Formula | Copies |
|---|---|---|---|
| NI | Nickel (II) ion | Ni | 1 |
Water and common crystallization additives (GOL) are not listed.
Crystal structure of the c-Src-SH3 domain in complex with the high affinity peptide VSL12. Camara-Artigas, A. To be published.
Other PDB entries of the same protein (UniProt P00523 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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