4RXZ: MDMX phosporylated Tyr99

Crystal Structure of MDMX phosporylated Tyr99 in complex with a 12-mer peptide. Determined by X-ray diffraction at 1.55 Å resolution. Released 22 Jul 2015.

Method: X-ray diffraction
Resolution: 1.55 Å
Organism: Homo sapiens
Chains: 4
Atoms: 1,655
Mol. weight: 22.51 kDa
Released: 22 Jul 2015

Explore 4RXZ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4RXZ contains 10 α-helices and 15 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	27	1	1
β-strand	28-29	2	2
α-helix	31-39	9
β-strand	47	1	1
α-helix	49-62	14
β-strand	66	1	3
β-strand	73-75	3	3
α-helix	80-85	6
β-strand	89-91	3	3
α-helix	96-105	10
β-strand	106-107	2	2

Chain B: 4 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	27	1	4
β-strand	28-29	2	5
α-helix	31-39	9
β-strand	47	1	4
α-helix	49-62	14
β-strand	66	1	6
β-strand	73-75	3	6
α-helix	80-85	6
β-strand	89-91	3	6
β-strand	94	1	6
α-helix	96-105	10
β-strand	106-107	2	5

Chains C and D: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	3-7	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Protein Mdm4	A, B	protein	85	Homo sapiens	O15151 (AlphaFold model)
12-mer peptide inhibitor	C, D	protein	12

Sequence of entity 1 (A, B), FASTA

>4RXZ_1 Protein Mdm4 (chains A, B)
INQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGE
LLGRQSFSVKDPSPLYDMLRKNLVT

Sequence of entity 2 (C, D), FASTA

>4RXZ_2 12-MER PEPTIDE INHIBITOR (chains C, D)
TSFAEYWNLLSP

Primary citation

Structural basis of how stress-induced MDMX phosphorylation activates p53. Chen, X., Gohain, N., Zhan, C. et al. Oncogene (2016) 35:1919-1925. DOI 10.1038/onc.2015.255 · PubMed

Other PDB entries of the same protein (UniProt O15151 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6Q9Y 1.2 Å, HDMX (14-111; C17S) COMPLEXED WITH COMPOUND 16 AT 1.20A; Structural states of Hdm2 and…
3FEA 1.33 Å, Crystal Structure of HdmX bound to the p53-peptidomimetic…
3FE7 1.35 Å, Crystal Structure of HdmX bound to the p53-peptidomimetic…
3FDO 1.4 Å, Structure of human MDMX in complex with high affinity peptide
3LBJ 1.5 Å, Structure of human MDMX protein in complex with a small molecule inhibitor
6Q9W 1.55 Å, X-ray structure of compound 15 bound to HdmX: Structural states of Hdm2 and HdmX: X-ray…
3EQY 1.63 Å, Crystal structure of human MDMX in complex with a 12-mer peptide inhibitor
7C3Y 1.63 Å, Crystal structure of the N-terminal domain of human MdmX protein in complex with Nutlin3a
7C44 1.65 Å, Crystal structure of the p53-binding domain of human MdmX protein in complex with Nutlin3a
8HDG 1.73 Å, Small peptide enhances the binding of nutline-3a to MdmX
3JZP 1.74 Å, Human MDMX liganded with a 12mer peptide inhibitor (pDI6W)
3JZO 1.8 Å, Human MDMX liganded with a 12mer peptide (pDI)

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