CtBP1 bound to inhibitor 2-(hydroxyimino)-3-phenylpropanoic acid. Determined by X-ray diffraction at 2.3 Å resolution. Released 11 Feb 2015.
Explore 4U6Q in 3D Show helices and sheets RCSB PDB PDBe
4U6Q contains 19 α-helices and 19 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 29-32 | 4 | 1 |
| α-helix | 42-45 | 4 | |
| β-strand | 50-53 | 4 | 1 |
| α-helix | 59-61 | 3 | |
| α-helix | 64-69 | 6 | |
| β-strand | 70-75 | 6 | 1 |
| β-strand | 81 | 1 | 2 |
| α-helix | 83-87 | 5 | |
| β-strand | 94-97 | 4 | 1 |
| β-strand | 105 | 1 | 2 |
| α-helix | 107-112 | 6 | |
| β-strand | 116-118 | 3 | 1 |
| α-helix | 125-141 | 17 | |
| α-helix | 143-152 | 10 | |
| α-helix | 159-165 | 7 | |
| β-strand | 176-180 | 5 | 3 |
| α-helix | 184-194 | 11 | |
| α-helix | 198 | 1 | |
| β-strand | 199-203 | 5 | 3 |
| α-helix | 208 | 1 | |
| α-helix | 211-214 | 4 | |
| β-strand | 218-219 | 2 | 3 |
| α-helix | 223-229 | 7 | |
| β-strand | 232-235 | 4 | 3 |
| α-helix | 237-239 | 3 | |
| β-strand | 247 | 1 | 4 |
| α-helix | 249-253 | 5 | |
| α-helix | 256 | 1 | |
| β-strand | 259-263 | 5 | 3 |
| α-helix | 267-269 | 3 | |
| β-strand | 270 | 1 | 4 |
| α-helix | 272-281 | 10 | |
| β-strand | 284-289 | 6 | 3 |
| β-strand | 298 | 1 | 5 |
| β-strand | 301 | 1 | 5 |
| β-strand | 310-312 | 3 | 3 |
| α-helix | 321-340 | 20 | |
| β-strand | 350 | 1 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| C-terminal-binding protein 1 | A | protein | 347 | Homo sapiens | Q13363 (AlphaFold model) |
>4U6Q_1 C-terminal-binding protein 1 (chains A) MGSSHHHHHHSSGLVPRGSHMPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKV LNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVE ETADSTLCHILNLYRRATWLHQALREGTRVQSVEQIREVASGAARIRGETLGIIGLGRVG QAVALRAKAFGFNVLFYDPYLSDGVERALGLQRVSTLQDLLFHSDCVTLHCGLNEHNHHL INDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFSQGPLKD APNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIPDSLKNCVNK
| ID | Name | Formula | Copies |
|---|---|---|---|
| NAI | 1,4-dihydronicotinamide adenine dinucleotide | C21 H29 N7 O14 P2 | 1 |
| 3CR | (2E)-2-(hydroxyimino)-3-phenylpropanoic acid | C9 H9 N O3 | 1 |
| CA | Calcium ion | Ca | 1 |
Water and common crystallization additives (FMT) are not listed.
Structure-Guided Design of a High Affinity Inhibitor to Human CtBP. Hilbert, B.J., Morris, B.L., Ellis, K.C. et al. ACS Chem Biol (2015) 10:1118-1127. DOI 10.1021/cb500820b · PubMed
Other PDB entries of the same protein (UniProt Q13363 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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