The complex structure of extracellular domain of EGFR with Repebody (rAC1). Determined by X-ray diffraction at 2.95 Å resolution. Released 25 Nov 2015.
Explore 4UIP in 3D Show helices and sheets RCSB PDB PDBe
4UIP contains 30 α-helices and 83 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 6-7 | 2 | 1 |
| β-strand | 10 | 1 | 2 |
| α-helix | 20-30 | 11 | |
| β-strand | 36-37 | 2 | 1 |
| β-strand | 40 | 1 | 2 |
| β-strand | 41-44 | 4 | 3 |
| α-helix | 53-57 | 5 | |
| β-strand | 60-61 | 2 | 1 |
| β-strand | 65-68 | 4 | 3 |
| β-strand | 74 | 1 | 4 |
| β-strand | 82-83 | 2 | 1 |
| β-strand | 93-98 | 6 | 3 |
| β-strand | 101 | 1 | 5 |
| β-strand | 107 | 1 | 5 |
| β-strand | 110 | 1 | 4 |
| β-strand | 118-119 | 2 | 1 |
| β-strand | 123-127 | 5 | 3 |
| β-strand | 144 | 1 | 1 |
| α-helix | 149-151 | 3 | |
| β-strand | 153-154 | 2 | 3 |
| α-helix | 171-173 | 3 | |
| β-strand | 175 | 1 | 6 |
| α-helix | 180-182 | 3 | |
| β-strand | 183 | 1 | 6 |
| α-helix | 184-185 | 2 | |
| β-strand | 199 | 1 | 7 |
| β-strand | 207 | 1 | 7 |
| β-strand | 212 | 1 | 8 |
| β-strand | 216 | 1 | 9 |
| β-strand | 224 | 1 | 9 |
| β-strand | 227 | 1 | 8 |
| β-strand | 230-231 | 2 | 10 |
| β-strand | 236-237 | 2 | 10 |
| α-helix | 240-242 | 3 | |
| β-strand | 244-246 | 3 | 11 |
| β-strand | 253-255 | 3 | 11 |
| β-strand | 261-263 | 3 | 10 |
| β-strand | 266-268 | 3 | 10 |
| β-strand | 276-277 | 2 | 12 |
| β-strand | 282 | 1 | 10 |
| β-strand | 283-284 | 2 | 12 |
| β-strand | 291-296 | 6 | 12 |
| β-strand | 299-304 | 6 | 12 |
| α-helix | 309-310 | 2 | |
| β-strand | 312-314 | 3 | 13 |
| α-helix | 319-321 | 3 | |
| α-helix | 333-335 | 3 | |
| β-strand | 340-342 | 3 | 13 |
| β-strand | 345-347 | 3 | 14 |
| α-helix | 350-353 | 4 | |
| β-strand | 355 | 1 | 15 |
| β-strand | 360 | 1 | 15 |
| α-helix | 361-363 | 3 | |
| α-helix | 365-373 | 9 | |
| β-strand | 376-377 | 2 | 13 |
| β-strand | 381-383 | 3 | 14 |
| β-strand | 401-402 | 2 | 13 |
| β-strand | 408 | 1 | 14 |
| β-strand | 412-417 | 6 | 14 |
| β-strand | 431-432 | 2 | 13 |
| β-strand | 436-440 | 5 | 14 |
| α-helix | 448-450 | 3 | |
| α-helix | 453-456 | 4 | |
| β-strand | 457 | 1 | 13 |
| β-strand | 464-467 | 4 | 14 |
| α-helix | 472-477 | 6 | |
| β-strand | 486 | 1 | 16 |
| β-strand | 491 | 1 | 17 |
| β-strand | 499 | 1 | 17 |
| β-strand | 502 | 1 | 16 |
| β-strand | 506 | 1 | 18 |
| β-strand | 524-527 | 4 | 18 |
| β-strand | 530-533 | 4 | 18 |
| α-helix | 534-535 | 2 | |
| β-strand | 538 | 1 | 19 |
| α-helix | 539-541 | 3 | |
| β-strand | 547 | 1 | 20 |
| β-strand | 555 | 1 | 20 |
| β-strand | 558 | 1 | 19 |
| β-strand | 561-563 | 3 | 21 |
| β-strand | 566-568 | 3 | 21 |
| β-strand | 573-576 | 4 | 22 |
| α-helix | 578-580 | 3 | |
| β-strand | 582-584 | 3 | 22 |
| β-strand | 585-587 | 3 | 23 |
| β-strand | 592 | 1 | 21 |
| β-strand | 593-595 | 3 | 23 |
| α-helix | 596-597 | 2 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 8-9 | 2 | 24 |
| α-helix | 10-13 | 4 | |
| α-helix | 17-26 | 10 | |
| β-strand | 35-36 | 2 | 24 |
| α-helix | 38-41 | 4 | |
| β-strand | 46-48 | 3 | 25 |
| α-helix | 60-62 | 3 | |
| β-strand | 68-70 | 3 | 25 |
| α-helix | 80-82 | 3 | |
| β-strand | 90-92 | 3 | 25 |
| α-helix | 101-102 | 2 | |
| β-strand | 114-116 | 3 | 25 |
| β-strand | 138-140 | 3 | 25 |
| α-helix | 149-150 | 2 | |
| β-strand | 162-164 | 3 | 25 |
| β-strand | 186-188 | 3 | 25 |
| β-strand | 194 | 1 | 26 |
| α-helix | 202-210 | 9 | |
| β-strand | 215-216 | 2 | 25 |
| β-strand | 222 | 1 | 25 |
| α-helix | 224-226 | 3 | |
| β-strand | 228 | 1 | 27 |
| β-strand | 229 | 1 | 26 |
| β-strand | 235 | 1 | 27 |
| α-helix | 236-238 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Epidermal growth factor receptor | A | protein | 618 | HOMO SAPIENS | P00533 (AlphaFold model) |
| Repebody (RAC1) | B | protein | 251 | LISTERIA MONOCYTOGENES, SYNTHETIC CONSTRUCT, EPTATRETUS BURGERI | E0ACT6 (AlphaFold model), Q4G1L3 (AlphaFold model) |
>4UIP_1 EPIDERMAL GROWTH FACTOR RECEPTOR (chains A) EEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEV AGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILH GAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEE NCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCP PLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRK CKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTP PLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNI TSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQV CHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQ AMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCT YGCTGPGLEGCPHHHHHH
>4UIP_2 REPEBODY (RAC1) (chains B) METITVSTPIKQIFPDDAFAETIKANLKKKSVTDAVTQNELNSIDQIIANNSDIKSVQGI QYLPNVRYLALGGNKLHDISALKELTNLTYLMLHYNQLQILPNGVFDKLTNLKELYLSEN QLQSLPDGVFDKLTNLTELDLARNQLQSLPKGVFDKLTQLKDLRLYQNQLKSVPDGVFDR LTSLQYIWLHDNPWDCTCPGIRYLSEWINKHSGVVRNSAGSVAPDSAKCSGSGKPVRSII CPTLEHHHHHH
| ID | Name | Formula | Copies |
|---|---|---|---|
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 2 |
Enzymatic Prenylation and Oxime Ligation for the Synthesis of Stable and Homogeneous Protein-Drug Conjugates for Targeted Therapy. Lee, J., Choi, H., Yun, M. et al. Angew Chem Int Ed Engl (2015) 54:12020. DOI 10.1002/ANIE.201505964 · PubMed
Other PDB entries of the same protein (UniProt P00533 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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