4YL6: Malcavernin

Crystal structure of truncated cerebral cavernous malformation 2 C-terminal adaptor domain in complex with an internal helix of mitogen-activated protein kinase kinase kinase 3. Determined by X-ray diffraction at 2.1 Å resolution. Released 3 Jun 2015.

Method: X-ray diffraction
Resolution: 2.1 Å
Organism: Homo sapiens
Chains: 2
Atoms: 928
Mol. weight: 13.9 kDa
Released: 3 Jun 2015

Explore 4YL6 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4YL6 contains 8 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 0 β-strands

Element	Residues	Length
α-helix	293-309	17
α-helix	312-326	15
α-helix	331-342	12
α-helix	347-351	5
α-helix	354-356	3
α-helix	359-361	3
α-helix	362-372	11

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	3-18	16

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Malcavernin	A	protein	96	Homo sapiens	Q9BSQ5 (AlphaFold model)
Mitogen-activated protein kinase kinase kinase 3	B	protein	22	Homo sapiens	Q99759 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4YL6_1 Malcavernin (chains A)
MELSASATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCINLRQLYGDSRKF
LLLGLRPFIPEKDSQHFENFLETIGVKDLEHHHHHH

Sequence of entity 2 (B), FASTA

>4YL6_2 Mitogen-activated protein kinase kinase kinase 3 (chains B)
MDEQEALNSIMNDLVALQMNRR

Primary citation

Structural Insights into the Molecular Recognition between Cerebral Cavernous Malformation 2 and Mitogen-Activated Protein Kinase Kinase Kinase 3. Wang, X., Hou, Y., Deng, K. et al. Structure (2015) 23:1087-1096. DOI 10.1016/j.str.2015.04.003 · PubMed

Other PDB entries of the same protein (UniProt Q9BSQ5 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4FQN 1.9 Å, Crystal structure of the CCM2 C-terminal Harmonin Homology Domain (HHD)
4YKD 1.93 Å, Crystal structure of truncated cerebral cavernous malformation 2 C-terminal adaptor domain
4Y5O 2.35 Å, CCM2 HHD in complex with MEKK3 NPB1
4YKC 2.7 Å, Crystal structure of cerebral cavernous malformation 2 C-terminal adaptor domain
4WJ7 2.75 Å, CCM2 PTB domain in complex with KRIT1 NPxY/F3
4TVQ 2.8 Å, CCM3 in complex with CCM2 LD-like motif
9PVG 3.0 Å, Co-crystal structure of two CCM2 PTB domains bound to a KRIT1 peptide encompassing NPxF2…

Browse structure collections

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