5FRP: Sister chromatid cohesion protein PDS5

Structure of the Pds5-Scc1 complex and implications for cohesin function. Determined by X-ray diffraction at 2.9 Å resolution. Released 2 Mar 2016.

Method
X-ray diffraction
Resolution
2.9 Å
Organism
SACCHAROMYCES CEREVISIAE
Chains
4
Atoms
11,116
Mol. weight
171.39 kDa
Released
2 Mar 2016

Explore 5FRP in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5FRP contains 87 α-helices and 4 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 44 helices, 1 β-strand

ElementResiduesLengthSheet
α-helix25-4117
α-helix53-586
α-helix62-654
α-helix70-8718
α-helix95-11319
α-helix120-13213
α-helix136-1416
α-helix145-15713
α-helix165-1673
α-helix168-18013
α-helix187-19913
α-helix215-22612
α-helix228-24720
α-helix254-27219
α-helix274-2796
α-helix281-2888
α-helix293-30614
α-helix315-3184
α-helix320-3278
α-helix328-3314
α-helix335-3439
α-helix345-3517
α-helix358-3669
α-helix372-38413
α-helix387-3937
α-helix397-4059
α-helix406-4083
β-strand40911
α-helix412-43120
α-helix440-4467
α-helix449-4557
α-helix456-4594
α-helix462-47110
α-helix472-4765
α-helix483-49513
α-helix499-52628
α-helix527-5293
α-helix540-55516
α-helix561-57414
α-helix577-58711
α-helix593-60715
α-helix626-64015
α-helix648-6536
α-helix662-67817
α-helix683-6908
Chain B: 43 helices, 1 β-strand
ElementResiduesLengthSheet
α-helix25-4117
α-helix53-586
α-helix62-654
α-helix70-8718
α-helix95-11218
α-helix120-13213
α-helix135-1417
α-helix145-15713
α-helix165-1673
α-helix168-18013
α-helix187-19913
α-helix215-22612
α-helix228-24720
α-helix254-27219
α-helix274-2796
α-helix281-2888
α-helix293-30614
α-helix315-3184
α-helix320-3278
α-helix328-3314
α-helix335-35117
α-helix358-3669
α-helix372-38413
α-helix387-3937
α-helix397-4059
α-helix406-4083
β-strand40912
α-helix412-43120
α-helix440-4467
α-helix449-4568
α-helix457-4593
α-helix462-47110
α-helix472-4765
α-helix483-49513
α-helix499-52628
α-helix544-55411
α-helix555-5573
α-helix561-57212
α-helix579-5879
α-helix593-60816
α-helix630-64011
α-helix648-6536
α-helix662-67817
α-helix684-69613
Chains C and D: 0 helices, 1 β-strand
ElementResiduesLengthSheet
β-strand12711

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Sister chromatid cohesion protein PDS5A, Bprotein703SACCHAROMYCES CEREVISIAEQ04264 (AlphaFold model)
MCD1-like proteinC, Dprotein44SACCHAROMYCES CEREVISIAEQ12158 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>5FRP_1 SISTER CHROMATID COHESION PROTEIN PDS5 (chains A, B)
GAMAKGAVTKLKFNSPIISTSDQLISTNELLDRLKALHEELASLDQDNTDLTGLDKYRDA
LVSRKLLKHKDVGIRAFTACCLSDILRLYAPDAPYTDAQLTDIFKLVLSQFEQLGDQENG
YHIQQTYLITKLLEYRSIVLLADLPSSNNLLIELFHIFYDPNKSFPARLFNVIGGILGEV
ISEFDSVPLEVLRLIFNKFLTYNPNEIPEGLNVTSDCGYEVSLILCDTYSNRMSRHLTKY
YSEIIHEATNDDNNSRLLTVVVKLHKLVLRLWETVPELINAVIGFIYHELSSENELFRKE
ATKLIGQILTSYSDLNFVSTHSDTFKAWISKIADISPDVRVEWTESIPQIIATREDISKE
LNQALAKTFIDSDPRVRRTSVMIFNKVPVTEIWKNITNKAIYTSLLHLAREKHKEVRELC
INTMAKFYSNSLNEIERTYQNKEIWEIIDTIPSTLYNLYYINDLNINEQVDSVIFEYLLP
FEPDNDKRVHRLLTVLSHFDKKAFTSFFAFNARQIKISFAISKYIDFSKFLNNQESMSSS
QGPIVMNKYNQTLQWLASGLSDSTKAIDALETIKQFNDERIFYLLNACVTNDIPFLTFKN
CYNELVSKLQTPGLFKKYNISTGASIMPRDIAKVIQILLFRASPIIYNVSNISVLLNLSN
NSDAKQLDLKRRILDDISKVNPTLFKDQIRTLKTIIKDLDDPD
Sequence of entity 2 (C, D), FASTA
>5FRP_2 MCD1-LIKE PROTEIN (chains C, D)
RLNTVTRVHQLMLEDAVTEREVLVTPGLEFLDDTTIPVGLMAQE

Primary citation

Structure of the Pds5-Scc1 Complex and Implications for Cohesin Function. Muir, K.W., Kschonsak, M., Li, Y. et al. Cell Rep (2016) 14:2116. DOI 10.1016/J.CELREP.2016.01.078 · PubMed

Other PDB entries of the same protein (UniProt Q04264 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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