5FRS: Sister chromatid cohesion protein PDS5

Structure of the Pds5-Scc1 complex and implications for cohesin function. Determined by X-ray diffraction at 4.07 Å resolution. Released 2 Mar 2016.

Method: X-ray diffraction
Resolution: 4.07 Å
Organism: SACCHAROMYCES CEREVISIAE
Chains: 2
Atoms: 5,623
Mol. weight: 82.63 kDa
Released: 2 Mar 2016

Explore 5FRS in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5FRS contains 47 α-helices and 4 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 47 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	7	1	1
α-helix	25-41	17
β-strand	47	1	1
α-helix	53-56	4
α-helix	58-60	3
α-helix	62-65	4
α-helix	70-87	18
α-helix	95-113	19
α-helix	120-132	13
α-helix	135-140	6
α-helix	145-156	12
α-helix	168-180	13
α-helix	187-199	13
α-helix	215-225	11
α-helix	228-247	20
α-helix	254-272	19
α-helix	274-279	6
α-helix	281-288	8
α-helix	293-306	14
α-helix	315-318	4
α-helix	320-326	7
α-helix	329-331	3
α-helix	335-342	8
α-helix	345-351	7
α-helix	358-366	9
α-helix	372-384	13
α-helix	387-393	7
α-helix	397-405	9
α-helix	406-408	3
β-strand	409	1	2
α-helix	412-428	17
α-helix	433-435	3
α-helix	439-441	3
α-helix	443-446	4
α-helix	449-454	6
α-helix	457-459	3
α-helix	462-472	11
α-helix	484-494	11
α-helix	499-526	28
α-helix	527-529	3
α-helix	540-547	8
α-helix	561-567	7
α-helix	571-574	4
α-helix	577-587	11
α-helix	593-606	14
α-helix	626-640	15
α-helix	649-653	5
α-helix	662-678	17
α-helix	680-683	4
α-helix	686-690	5

Chain C: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	127	1	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Sister chromatid cohesion protein PDS5	A	protein	703	SACCHAROMYCES CEREVISIAE	Q04264 (AlphaFold model)
Sister chromatid cohesion protein 1	C	protein	17	SACCHAROMYCES CEREVISIAE	Q12158 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>5FRS_1 SISTER CHROMATID COHESION PROTEIN PDS5 (chains A)
GAMAKGAVTKLKFNSPIISTSDQLISTNELLDRLKALHEELASLDQDNTDLTGLDKYRDA
LVSRKLLKHKDVGIRAFTACCLSDILRLYAPDAPYTDAQLTDIFKLVLSQFEQLGDQENG
YHIQQTYLITKLLEYRSIVLLADLPSSNNLLIELFHIFYDPNKSFPARLFNVIGGILGEV
ISEFDSVPLEVLRLIFNKFLTYNPNEIPEGLNVTSDCGYEVSLILCDTYSNRMSRHLTKY
YSEIIHEATNDDNNSRLLTVVVKLHKLVLRLWETVPELINAVIGFIYHELSSENELFRKE
ATKLIGQILTSYSDLNFVSTHSDTFKAWISKIADISPDVRVEWTESIPQIIATREDISKE
LNQALAKTFIDSDPRVRRTSVMIFNKVPVTEIWKNITNKAIYTSLLHLAREKHKEVRELC
INTMAKFYSNSLNEIERTYQNKEIWEIIDTIPSTLYNLYYINDLNINEQVDSVIFEYLLP
FEPDNDKRVHRLLTVLSHFDKKAFTSFFAFNARQIKISFAISKYIDFSKFLNNQESMSSS
QGPIVMNKYNQTLQWLASGLSDSTKAIDALETIKQFNDERIFYLLNACVTNDIPFLTFKN
CYNELVSKLQTPGLFKKYNISTGASIMPRDIAKVIQILLFRASPIIYNVSNISVLLNLSN
NSDAKQLDLKRRILDDISKVNPTLFKDQIRTLKTIIKDLDDPD

Sequence of entity 2 (C), FASTA

>5FRS_2 SISTER CHROMATID COHESION PROTEIN 1 (chains C)
LMMEDAVTEREVLVTPG

Primary citation

Structure of the Pds5-Scc1 Complex and Implications for Cohesin Function. Muir, K.W., Kschonsak, M., Li, Y. et al. Cell Rep (2016) 14:2116. DOI 10.1016/J.CELREP.2016.01.078 · PubMed

Other PDB entries of the same protein (UniProt Q04264 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5FRP 2.9 Å, Structure of the Pds5-Scc1 complex and implications for cohesin function
5FRR 5.8 Å, Structure of the Pds5-Scc1 complex and implications for cohesin function

Browse structure collections

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