5IXD: Human JAK1 FERM/SH2

Name: PDB 5IXD: Structure of human JAK1 FERM/SH2 in complex with IFN lambda receptor
Published: 2016-05-18
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: cytokine

Structure of human JAK1 FERM/SH2 in complex with IFN lambda receptor. Determined by X-ray diffraction at 2.85 Å resolution. Released 18 May 2016.

Method: X-ray diffraction
Resolution: 2.85 Å
Organism: Homo sapiens
Chains: 2
Atoms: 3,466
Mol. weight: 69.69 kDa
Ligands: CIT
Released: 18 May 2016

Explore 5IXD in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5IXD contains 25 α-helices and 24 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 22 helices, 24 β-strands

Element	Residues	Length	Sheet
β-strand	37-39	3	1
β-strand	48-49	2	1
β-strand	54-56	3	2
α-helix	57-67	11
α-helix	74-77	4
β-strand	78-82	5	1
β-strand	87-88	2	1
α-helix	89-90	2
β-strand	94-96	3	2
β-strand	104-109	6	1
β-strand	128	1	3
α-helix	152-167	16
α-helix	172	1
β-strand	173	1	4
α-helix	174-176	3
α-helix	179-203	25
α-helix	217-219	3
α-helix	223-230	8
α-helix	234-250	17
α-helix	251-255	5
α-helix	256-258	3
α-helix	263-277	15
β-strand	278	1	4
β-strand	284-288	5	5
β-strand	290-295	6	6
β-strand	298-303	6	6
β-strand	313-318	6	5
β-strand	322-327	6	5
α-helix	328-329	2
α-helix	362-363	2
β-strand	364-367	4	5
α-helix	369-371	3
β-strand	372-378	7	6
β-strand	381-386	6	6
β-strand	391-395	5	6
α-helix	399-416	18
α-helix	425-427	3
α-helix	430-437	8
α-helix	446-454	9
β-strand	474	1	7
β-strand	501-502	2	7
β-strand	507-508	2	7
β-strand	516	1	7
α-helix	519-524	6
α-helix	546-547	2
β-strand	556	1	3

Chain B: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	256-258	3
α-helix	260-261	2
α-helix	265-267	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Tyrosine-protein kinase JAK1	A	protein	544	Homo sapiens	P23458 (AlphaFold model)
Interferon lambda receptor 1	B	protein	55	Homo sapiens	Q8IU57 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>5IXD_1 Tyrosine-protein kinase JAK1 (chains A)
MHHHHHHGENLYFQGSGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLF
ALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGY
EKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAIS
HYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICD
SSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVT
GNLGIQWRHKPNVVSVEKEKNKLKRKKLENKDKKDEEKNKIREEWNNFSFFPEITHIVIK
ESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQN
GCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNF
QIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVAT
KGNS

Sequence of entity 2 (B), FASTA

>5IXD_2 Interferon lambda receptor 1 (chains B)
GSKTLMGNPWFQRAKMPRALDFSGHTHPVATFQPSRPESVNDLFLCPQKELTGNS

Ligands and cofactors

ID	Name	Formula	Copies
CIT	Citric acid	C6 H8 O7	1

Primary citation

The Structural Basis for Class II Cytokine Receptor Recognition by JAK1. Ferrao, R., Wallweber, H.J., Ho, H. et al. Structure (2016) 24:897-905. DOI 10.1016/j.str.2016.03.023 · PubMed

Other PDB entries of the same protein (UniProt P23458 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6N7A 1.33 Å, Structure of the human JAK1 kinase domain with compound 39
10PI 1.54 Å, JAK1 kinase (JH1 domain) in complex with povorcitinib
6N77 1.64 Å, Structure of the human JAK1 kinase domain with compound 15
6N7C 1.69 Å, Structure of the human JAK1 kinase domain with compound 56
6GGH 1.7 Å, Human jak1 kinase domain in complex with inhibitor
6RSH 1.71 Å, Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole…
8S85 1.75 Å, Crystal structure of JAK1 JH1 domain in complex with an inhibitor
6RSD 1.76 Å, Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole…
6N7D 1.78 Å, Structure of the human JAK1 kinase domain with compound 54
4GS0 1.8 Å, Crystal structure of SHP1 catalytic domain with JAK1 activation loop peptide
4L00 1.8 Å, Crystal structure of the apo Jak1 pseudokinase domain
6ELR 1.8 Å, Human jak1 kinase domain in complex with compound 7

Browse structure collections

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