Interferon lambda receptor 1 (IFNLR1) is a 520-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8IU57.
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The mean pLDDT of this model is 64.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 33% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 46% |
What pLDDT means and how to read it
The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important…
Heterodimer with IL10RB
Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3OG6 | X-ray | 2.1 Å | B=19-226 |
| 5L04 | X-ray | 2.1 Å | B=260-307 |
| 3OG4 | X-ray | 2.16 Å | B=19-226 |
| 5IXI | X-ray | 2.57 Å | B=250-260 |
| 5IXD | X-ray | 2.85 Å | B=250-299 |
| 5T5W | X-ray | 2.85 Å | B=21-226 |
| 9BPV | EM | 3.0 Å | B=21-226 |
| 9BPU | EM | 3.26 Å | B=21-226 |
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