5JPA: Hexameric HIV-1 CA H12Y mutant

Hexameric HIV-1 CA H12Y mutant. Determined by X-ray diffraction at 1.7 Å resolution. Released 10 Aug 2016.

Method: X-ray diffraction
Resolution: 1.7 Å
Organism: Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)
Chains: 1
Atoms: 1,811
Mol. weight: 25.49 kDa
Released: 10 Aug 2016

Explore 5JPA in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5JPA contains 14 α-helices and 2 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 14 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	2-4	3	1
β-strand	10-12	3	1
α-helix	14-16	3
α-helix	17-30	14
α-helix	36-43	8
α-helix	49-57	9
α-helix	63-83	21
α-helix	96-99	4
α-helix	101-104	4
α-helix	111-118	8
α-helix	126-145	20
α-helix	150-152	3
α-helix	161-175	15
α-helix	187-192	6
α-helix	196-205	10
α-helix	211-217	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Capsid Protein P24	A	protein	231	Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)	P12493

Sequence of entity 1 (A), FASTA

>5JPA_1 Capsid Protein P24 (chains A)
PIVQNLQGQMVYQCISPRTLNAWVKVVEEKAFSPEVIPMFSALSCGATPQDLNTMLNTVG
GHQAAMQMLKETINEEAAEWDRLHPVHAGPIAPGQMREPRGSDIAGTTSTLQEQIGWMTH
NPPIPVGEIYKRWIILGLNKIVRMYSPTSILDIRQGPKEPFRDYVDRFYKTLRAEQASQE
VKNAATETLLVQNANPDCKTILKALGPGATLEEMMTACQGVGGPGHKARVL

Primary citation

HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis. Jacques, D.A., McEwan, W.A., Hilditch, L. et al. Nature (2016) 536:349-353. DOI 10.1038/nature19098 · PubMed

Other PDB entries of the same protein (UniProt P12493), best resolution first:

8QUK 1.38 Å, Hexameric HIV-1 CA in complex with DDD00100439
8QUH 1.55 Å, Hexameric HIV-1 CA in complex with DDD00057456
8FIU 1.56 Å, Potent long-acting inhibitors targeting HIV-1 capsid based on a versatile…
8QUB 1.63 Å, Hexameric HIV-1 CA in complex with DDD00074110
8QUJ 1.63 Å, Hexameric HIV-1 CA in complex with DDD00100452
8QUL 1.67 Å, Hexameric HIV-1 CA in complex with DDD00100555
8QUI 1.69 Å, Hexameric HIV-1 CA in complex with DDD00024969
8QV9 1.76 Å, Hexameric HIV-1 CA in complex with DDD01829021
4U0C 1.77 Å, Hexameric HIV-1 CA in complex with Nup153 peptide, P6 crystal form
8VRP 1.8 Å, HIV-CA Disulfide linked Hexamer bound to 4-Quinazolinone Scaffold inhibitor
8QUY 1.88 Å, Hexameric HIV-1 CA in complex with DDD01728501
5TSX 1.9 Å, HIV-1 CA hexamer with NUP153 peptide - P1 crystal form

Browse structure collections

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