5L3M: D11 bound [S39_PQ]-IGF-II

D11 bound [S39_PQ]-IGF-II. Determined by solution NMR. Released 10 Aug 2016.

Method: Solution NMR
Organism: Homo sapiens
Chains: 1
Atoms: 536
Mol. weight: 7.71 kDa
Released: 10 Aug 2016

Explore 5L3M in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5L3M contains 6 α-helices and 4 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 6 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	11-21	11
α-helix	22-24	3
β-strand	26	1	1
β-strand	29	1	2
α-helix	40-41	2
β-strand	43	1	2
α-helix	44-48	5
α-helix	55-58	4
α-helix	59-61	3
β-strand	62	1	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Insulin-like growth factor II	A	protein	69	Homo sapiens	P01344 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>5L3M_1 Insulin-like growth factor II (chains A)
AYRPSETLCGGELVDTLQFVCGDRGFYFSRPASRVSRRSPQRGIVEECCFRSCDLALLET
YCATPAKSE

Primary citation

Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain. Hexnerova, R., Krizkova, K., Fabry, M. et al. J Biol Chem (2016) 291:21234-21245. DOI 10.1074/jbc.M116.741041 · PubMed

Other PDB entries of the same protein (UniProt P01344 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3KR3 2.2 Å, Crystal structure of IGF-II antibody complex
3E4Z 2.28 Å, Crystal structure of human insulin degrading enzyme in complex with insulin-like growth…
6VWG 3.21 Å, Head region of the open conformation of the human type 1 insulin-like growth factor…
8YSZ 3.38 Å, Cryo-EM structure of the complex IR with three IGF-II
8U4C 3.6 Å, Cryo-EM structure of long form insulin receptor (IR-B) with four IGF2 bound, symmetric…
8VJB 3.6 Å, Cryo-EM structure of short form insulin receptor (IR-A) with four IGF2 bound, symmetric…
6VWI 3.7 Å, Head region of the closed conformation of the human type 1 insulin-like growth factor…
8VJC 3.8 Å, Cryo-EM structure of short form insulin receptor (IR-A) with three IGF2 bound,…
2V5P 4.1 Å, Complex structure of human IGF2R domains 11-13 bound to igf-II
8U4E 4.2 Å, Cryo-EM structure of long form insulin receptor (IR-B) with three IGF2 bound, asymmetric…
6UM2 4.32 Å, Structure of M-6-P/IGFII Receptor and IGFII complex
1IGL Solution structure of human insulin-like growth factor II relationship to receptor and…

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