5VTJ: PDB entry 5VTJ

Structure of Pin1 WW Domain Sequence 1 Substituted with [S,S]ACPC. Determined by X-ray diffraction at 1.5 Å resolution. Released 21 Feb 2018.

Method: X-ray diffraction
Resolution: 1.5 Å
Organism: Homo sapiens
Chains: 1
Atoms: 360
Mol. weight: 4.25 kDa
Released: 21 Feb 2018

Explore 5VTJ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5VTJ contains 2 α-helices and 3 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	7-8	2
β-strand	11-16	6	1
β-strand	21-26	6	1
β-strand	32-33	2	1
α-helix	36-37	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	A	protein	34	Homo sapiens	Q13526 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>5VTJ_1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (chains A)
KLPPGWEKRMSRXSGRVYYFNHITNASQWERPSG

Primary citation

Evaluation of beta-Amino Acid Replacements in Protein Loops: Effects on Conformational Stability and Structure. Mortenson, D.E., Kreitler, D.F., Thomas, N.C. et al. Chembiochem (2018) 19:604-612. DOI 10.1002/cbic.201700580 · PubMed

Other PDB entries of the same protein (UniProt Q13526 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7AZ2 1.08 Å, 14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1014
7AZ1 1.15 Å, 14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1013
3I6C 1.3 Å, Structure-Based Design of Novel PIN1 Inhibitors (II)
4TNS 1.33 Å, Structure of Pin1 PPIase domain bound with all-trans retinoic acid
1PIN 1.35 Å, PIN1 peptidyl-prolyl cis-trans isomerase from homo sapiens
3TC5 1.4 Å, Selective targeting of disease-relevant protein binding domains by O-phosphorylated…
7AXN 1.4 Å, 14-3-3 sigma in complex with Pin1 binding site pS72 and covalently bound TCF521-026
7BG3 1.4 Å, 14-3-3 sigma with Pin1 binding site pS72 and covalently bound PC2046
6VAJ 1.42 Å, Crystal Structure Analysis of human PIN1
9KFZ 1.43 Å, Crystal structure of the PIN1 and fragment 59 complex
2ITK 1.45 Å, human Pin1 bound to D-PEPTIDE
2ZQT 1.46 Å, Crystal structure of a mutant PIN1 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE

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