5VZM: Human Rev1

Solution NMR structure of human Rev1 (932-1039) in complex with ubiquitin. Determined by solution NMR. Released 23 May 2018.

Method: Solution NMR
Organism: Homo sapiens
Chains: 2
Atoms: 1,443
Mol. weight: 20.56 kDa
Released: 23 May 2018

Explore 5VZM in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5VZM contains 11 α-helices and 7 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	2-7	6	1
β-strand	12-16	5	1
β-strand	22	1	2
α-helix	23-34	12
α-helix	38-40	3
β-strand	41-45	5	1
β-strand	48-49	2	1
β-strand	55	1	2
α-helix	57-59	3
β-strand	66-71	6	1

Chain B: 8 helices, 0 β-strands

Element	Residues	Length
α-helix	932-934	3
α-helix	939-942	4
α-helix	947-954	8
α-helix	959-962	4
α-helix	984-986	3
α-helix	993-995	3
α-helix	1017-1022	6
α-helix	1025-1036	12

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Ubiquitin	A	protein	76	Homo sapiens	P0CG47 (AlphaFold model)
DNA repair protein REV1	B	protein	111	Homo sapiens	Q9UBZ9 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>5VZM_1 Ubiquitin (chains A)
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYN
IQKESTLHLVLRLRGG

Sequence of entity 2 (B), FASTA

>5VZM_2 DNA repair protein REV1 (chains B)
GHMPSPSQLDQSVLEALPPDLREQVEQVCAVQQAESHGDKKKEPVNGCNTGILPQPVGTV
LLQIPEPQESNSDAGINLIALPAFSQVDPEVFAALPAELQRELKAAYDQRQ

Primary citation

Structural Basis for the Interaction of Mutasome Assembly Factor REV1 with Ubiquitin. Cui, G., Botuyan, M.V., Mer, G. J Mol Biol (2018) 430:2042-2050. DOI 10.1016/j.jmb.2018.05.017 · PubMed

Other PDB entries of the same protein (UniProt P0CG47 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5NVG 1.07 Å, Thr12 Phosphorylated Ubiquitin
5TOG 1.08 Å, Room temperature structure of ubiquitin variant u7ub25.2540
5TOF 1.12 Å, Room temperature structure of ubiquitin variant u7ub25
4XOF 1.15 Å, Observing the overall rocking motion of a protein in a crystal - Orthorhombic Ubiquitin…
5GOD 1.15 Å, Lys27-linked di-ubiquitin
5GOB 1.15 Å, Lys6-linked di-ubiquitin
5W46 1.18 Å, Structure of S65D Phosphomimetic Ubiquitin Refined at 1.2 Angstroms Resolution
7S6O 1.25 Å, The crystal structure of Lys48-linked di-ubiquitin
8IC9 1.25 Å, Lys48-linked K48C-diubiquitin
5DK8 1.32 Å, Human ubiquitin in the P1 space group
7CAP 1.33 Å, Cyclic Lys48-linked triubiquitin
5V1Y 1.42 Å, Crystal structure of the ternary RPN13 PRU-RPN2 (940-953)-ubiquitin complex

Browse structure collections

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