5XAH: Human Importin4

Crystal structure of human Importin4. Determined by X-ray diffraction at 3.0 Å resolution. Released 14 Feb 2018.

Method
X-ray diffraction
Resolution
3.0 Å
Organism
Homo sapiens
Chains
4
Atoms
11,255
Mol. weight
180.47 kDa
Released
14 Feb 2018

Explore 5XAH in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5XAH contains 105 α-helices and 4 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 26 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix695-7039
α-helix704-7063
α-helix711-73222
α-helix738-75922
α-helix765-78117
α-helix784-7874
α-helix792-80413
α-helix826-84621
α-helix852-86413
α-helix872-88918
α-helix890-8967
α-helix897-90711
α-helix913-93523
α-helix938-9458
α-helix948-9514
α-helix955-97117
α-helix979-98810
α-helix9891
α-helix9911
α-helix997-101115
α-helix1016-10183
α-helix1020-10256
α-helix1027-10293
α-helix1038-105417
α-helix1056-10627
α-helix1068-107710
Chain B: 27 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix695-70410
α-helix705-7073
α-helix711-73424
α-helix738-76124
α-helix765-78117
α-helix783-7853
α-helix792-80514
α-helix828-84619
α-helix852-86312
α-helix864-8663
α-helix872-88918
α-helix890-8967
α-helix897-90711
α-helix913-92917
α-helix931-9355
α-helix938-95114
α-helix955-97117
α-helix979-9879
α-helix9891
α-helix9911
α-helix995-9973
α-helix998-101114
α-helix1016-10194
α-helix1020-103112
α-helix1038-105417
α-helix1056-10649
α-helix1068-107710
Chain C: 28 helices, 2 β-strands
ElementResiduesLengthSheet
α-helix691-6933
α-helix696-7049
α-helix705-7073
α-helix711-73424
α-helix738-76124
α-helix765-78218
α-helix783-7864
α-helix792-80514
α-helix827-83610
α-helix838-8469
α-helix852-86413
β-strand86811
β-strand87011
α-helix872-88918
α-helix890-8967
α-helix897-90711
α-helix913-92917
α-helix931-9355
α-helix938-9458
α-helix947-9515
α-helix955-97016
α-helix979-98810
α-helix9891
α-helix9911
α-helix995-9973
α-helix998-101114
α-helix1013-10164
α-helix1020-103112
α-helix1038-105417
α-helix1056-10638
Chain D: 24 helices, 2 β-strands
ElementResiduesLengthSheet
α-helix696-7038
α-helix704-7074
α-helix711-73222
α-helix738-76124
α-helix765-78117
α-helix783-7875
α-helix792-80413
α-helix828-84619
α-helix852-86413
β-strand86812
β-strand87012
α-helix872-88716
α-helix890-8967
α-helix897-90812
α-helix913-92917
α-helix931-9355
α-helix938-95114
α-helix955-96915
α-helix979-98810
α-helix9891
α-helix9911
α-helix997-101115
α-helix1020-103011
α-helix1038-105316
α-helix1056-10638
α-helix1070-10778

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Importin-4A, B, C, Dprotein416Homo sapiensQ8TEX9 (AlphaFold model)
Sequence of entity 1 (A, B, C, D), FASTA
>5XAH_1 Importin-4 (chains A, B, C, D)
GSAFFDEKEDTCAAVGEISVNTSVAFLPYMESVFEEVFKLLECPHLNVRKAAHEALGQFC
CALHKACQSCPSEPNTAALQAALARVVPSYMQAVNRERERQVVMAVLEALTGVLRSCGTL
TLKPPGRLAELCGVLKAVLQRKTACQDTDEEEEEEDDDQAEYDAMLLEHAGEAIPALAAA
AGGDSFAPFFAGFLPLLVCKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVSRLLPVLL
STAQEADPEVRSNAIFGMGVLAEHGGHPAQEHFPKLLGLLFPLLARERHDRVRDNICGAL
ARLLMASPTRKPEPQVLAALLHALPLKEDLEEWVTIGRLFSFLYQSSPDQVIDVAPELLR
ICSLILADNKIPPDTKAALLLLLTFLAKQHTDSFQAALGSLPVDKAQELQAVLGLS

Primary citation

Integrative Structural Investigation on the Architecture of Human Importin4_Histone H3/H4_Asf1a Complex and Its Histone H3 Tail Binding. Yoon, J., Kim, S.J., An, S. et al. J Mol Biol (2018) 430:822-841. DOI 10.1016/j.jmb.2018.01.015 · PubMed

Other PDB entries of the same protein (UniProt Q8TEX9 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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