5Y81: NuA4 TEEAA sub-complex

NuA4 TEEAA sub-complex. Determined by electron microscopy at 4.7 Å resolution. Released 18 Apr 2018.

Method
Electron microscopy
Resolution
4.7 Å
Organisms
Saccharomyces cerevisiae S288c, Saccharomyces cerevisiae
Chains
8
Atoms
25,723
Mol. weight
648.79 kDa
Released
18 Apr 2018

Explore 5Y81 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5Y81 contains 241 α-helices and 48 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 113 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix5-128
α-helix22-3514
α-helix42-5413
α-helix71-8414
α-helix92-10413
α-helix113-12917
α-helix139-15820
α-helix218-2258
α-helix232-24413
α-helix249-2557
α-helix288-30215
α-helix305-3139
α-helix324-33512
α-helix341-36020
α-helix369-37911
α-helix387-40418
α-helix411-42414
α-helix432-45019
α-helix460-50243
α-helix510-5145
α-helix517-5215
α-helix578-5814
α-helix583-60422
α-helix630-64617
α-helix675-69117
α-helix697-7015
α-helix705-7128
α-helix719-73012
α-helix737-74711
α-helix758-77518
α-helix787-79711
α-helix806-8094
α-helix814-8174
α-helix831-84414
α-helix852-86211
α-helix875-88511
α-helix892-90312
α-helix908-9125
α-helix914-92916
α-helix939-95113
α-helix954-9574
α-helix970-9723
α-helix998-10058
α-helix1012-102817
α-helix1039-105012
α-helix1070-109021
α-helix1098-112528
α-helix1143-115210
α-helix1159-117315
α-helix1183-120119
α-helix1208-122316
α-helix1230-124617
α-helix1256-127015
α-helix1281-129212
α-helix1300-131415
α-helix1319-133113
α-helix1348-135811
α-helix1373-138412
α-helix1403-141816
α-helix1432-144615
α-helix1453-146816
α-helix1476-148712
α-helix1497-150610
α-helix1520-15289
α-helix1535-15428
α-helix1547-156115
α-helix1568-158114
α-helix1593-15997
α-helix1606-16149
α-helix1618-162912
α-helix1636-165217
α-helix1663-167917
α-helix1692-170615
α-helix1717-173418
α-helix1741-17499
α-helix1760-17678
α-helix1777-178711
α-helix1799-181517
α-helix1830-184314
α-helix1861-187111
α-helix1880-189415
α-helix1901-19099
α-helix1918-19203
α-helix1921-193010
α-helix1938-195215
α-helix1961-197212
α-helix1980-198910
α-helix2001-201616
α-helix2024-204219
α-helix2091-210616
α-helix2116-212914
α-helix2141-21466
α-helix2156-217217
α-helix2179-219113
α-helix2203-221816
α-helix2226-224318
α-helix2252-226615
α-helix2271-228818
α-helix2302-231716
α-helix2329-23379
α-helix2346-235813
α-helix2370-238314
α-helix2388-240013
α-helix2409-24179
α-helix2431-244111
α-helix2451-246010
α-helix2468-247912
α-helix2519-253012
α-helix2539-254911
α-helix2553-256715
α-helix2574-258613
α-helix2600-260910
α-helix2619-26257
Chain B: 56 helices, 5 β-strands
ElementResiduesLengthSheet
α-helix2634-26429
α-helix2652-266716
α-helix2677-26793
α-helix2689-26957
α-helix2701-271212
α-helix2724-273916
α-helix2745-27473
α-helix2748-27525
α-helix2759-27635
α-helix2774-278411
α-helix2789-280618
α-helix2810-282718
α-helix2836-286530
α-helix2875-288511
α-helix2896-29005
α-helix2903-291614
α-helix2917-29226
α-helix2943-295614
α-helix2962-29698
α-helix2981-299414
α-helix2999-30079
α-helix3016-303217
α-helix3039-304911
α-helix3055-306915
α-helix3077-309216
α-helix3095-30973
α-helix3100-311011
α-helix3117-31215
α-helix3130-31323
α-helix3139-31413
α-helix3150-316213
α-helix3167-318014
α-helix3204-321613
α-helix3223-323614
α-helix3238-32403
α-helix3243-326220
α-helix3274-32829
α-helix3283-32875
α-helix3293-32997
α-helix3308-332619
α-helix3357-33593
α-helix3411-343121
α-helix3436-34394
β-strand344911
β-strand345711
β-strand3465-346622
α-helix3467-347812
α-helix3483-349715
α-helix3504-352118
α-helix3526-35349
α-helix3541-355212
α-helix3556-35605
β-strand3573-357532
β-strand3580-358122
α-helix3638-365316
α-helix3659-367921
α-helix3688-370316
α-helix37151
α-helix3719-372810
α-helix3730-37345
α-helix3741-37433
Chain C: 8 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix649-66113
α-helix668-6736
α-helix680-6878
α-helix692-70514
α-helix710-7134
α-helix722-7309
α-helix751-76818
α-helix796-80813
Chain D: 11 helices, 2 β-strands
ElementResiduesLengthSheet
α-helix4-85
α-helix54-618
α-helix151-16313
α-helix166-1705
α-helix171-18010
α-helix277-2826
α-helix285-2906
α-helix310-3189
α-helix363-3664
β-strand37713
β-strand38513
α-helix419-43012
α-helix440-4478
Chain E: 2 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix359-3657
α-helix368-39528
Chain F: 21 helices, 21 β-strands
ElementResiduesLengthSheet
α-helix14-152
β-strand17-2154
β-strand25-3064
β-strand38-4144
β-strand43-4535
β-strand5615
β-strand71-7335
β-strand75-7626
β-strand79-8026
α-helix83-9614
β-strand108-11034
α-helix118-1258
α-helix126-1327
β-strand136-13944
α-helix142-1465
β-strand155-16067
β-strand165-17067
α-helix177-1793
β-strand181-18337
α-helix187-19711
β-strand209-21138
β-strand217-21828
α-helix219-2202
α-helix227-2348
α-helix238-2425
α-helix255-2639
β-strand26819
β-strand271110
β-strand277110
β-strand28019
α-helix282-29312
α-helix297-2993
α-helix3011
α-helix385-39511
α-helix401-4055
β-strand408-40927
α-helix420-43112
α-helix447-46014
α-helix463-4686
β-strand470-47124
α-helix472-4787
α-helix483-4864
Chain G: 21 helices, 20 β-strands
ElementResiduesLengthSheet
β-strand8-10311
β-strand17-21511
β-strand29-31311
β-strand35-36212
β-strand54112
α-helix57-604
β-strand67-68212
β-strand71-72213
β-strand75-76213
α-helix79-8810
α-helix89-935
α-helix98-1003
β-strand103-107514
α-helix113-12614
β-strand131-136614
α-helix137-1448
β-strand150-153415
β-strand160-162316
β-strand163-166415
β-strand169-170215
β-strand176-178316
α-helix182-19413
α-helix206-21611
α-helix223-2319
β-strand238-241417
β-strand247-250417
α-helix253-2564
α-helix258-2603
α-helix264-2674
α-helix274-2829
α-helix290-2956
β-strand297-299315
α-helix302-3043
α-helix309-31810
β-strand329-330215
α-helix335-3373
α-helix338-34811
α-helix353-3553
β-strand357-358214
α-helix359-3646
α-helix367-3715
Chain H: 9 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix4-1512
α-helix25-295
α-helix46-6116
α-helix79-857
α-helix87-915
α-helix110-12314
α-helix182-19413
α-helix223-24220
α-helix257-26812

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Transcription-associated protein 1Bprotein1115Saccharomyces cerevisiae S288cP38811
Chromatin modification-related protein EAF1Cprotein336Saccharomyces cerevisiae S288cQ06337 (AlphaFold model)
Eaf1-disorder domainDprotein500Saccharomyces cerevisiae
Chromatin modification-related protein EAF5Hprotein279Saccharomyces cerevisiae S288cP39995 (AlphaFold model)
Transcription-associated protein 1Aprotein2627Saccharomyces cerevisiae S288cP38811
Actin-related protein 4Fprotein490Saccharomyces cerevisiae S288cP80428 (AlphaFold model)
ActinGprotein375Saccharomyces cerevisiae S288cP60010
Chromatin modification-related protein EAF1Eprotein41Saccharomyces cerevisiae S288cQ06337 (AlphaFold model)
Sequence of entity 1 (B), FASTA
>5Y81_1 Transcription-associated protein 1 (chains B)
YNAWYQSINILESIQSNTSIDNTKIIEANEDALLELYVNLQEEDMFYGLWRRRAKYTETN
IGLSYEQIGLWDKAQQLYEVAQVKARSGALPYSQSEYALWEDNWIQCAEKLQHWDVLTEL
AKHEGFTDLLLECGWRVADWNSDRDALEQSVKSVMDVPTPRRQMFKTFLALQNFAESRKG
DQEVRKLCDEGIQLSLIKWVSLPIRYTPAHKWLLHGFQQYMEFLEATQIYANLHTTTVQN
LDSKAQEIKRILQAWRDRLPNTWDDVNMWNDLVTWRQHAFQVINNAYLPLIPALQQSNSN
SNINTHAYRGYHEIAWVINRFAHVARKHNMPDVCISQLARIYTLPNIEIQEAFLKLREQA
KCHYQNMNELTTGLDVISNTNLVYFGTVQKAEFFTLKGMFLSKLRAYEEANQAFATAVQI
DLNLAKAWAQWGFFNDRRLSEEPNNISFASNAISCYLQAAGLYKNSKIRELLCRILWLIS
IDDASGMLTNAFDSFRGEIPVWYWITFIPQLLTSLSHKEANMVRHILIRIAKSYPQALHF
QLRTTKEDFAVIQRQTMAVMGDKPDTNDRNGRRQPWEYLQELNNILKTAYPLLALSLESL
VAQINDRFKSTTDEDLFRLINVLLIDGTLNYNRLPFPRKNPKLPENTEKNLVKFSTTLLA
PYIRPKFNADFIDNKPDYETYIKRLRYWRRRLENKLDRASKKENLEVLCPHLSNFHHQKF
EDIEIPGQYLLNKDNNVHFIKIARFLPTVDFVRGTHSSYRRLMIRGHDGSVHSFAVQYPA
VRHSRREERMFQLYRLFNKSLSKNVETRRRSIQFNLPIAIPLSPQVRIMNDSVSFTTLHE
IHNEFCKKKGFDPDDIQDFMADKLNAAHDDALPAPDMTILKVEIFNSIQTMFVPSNVLKD
HFTSLFTQFEDFWLFRKQFASQYSSFVFMSYMMMINNRTPHKIHVDKTSGNVFTLEMLPS
RFPYERVKPLLKNHDLSLPPDSPIFHNNEPVPFRLTPNIQSLIGDSALEGIFAVNLFTIS
RALIEPDNELNTYLALFIRDEIISWFSNLHRPIIENPQLREMVQTNVDLIIRKVAQLGHL
NSTPTVTTQFILDCIGSAVSPRNLARTDVNFMPWF
Sequence of entity 2 (C), FASTA
>5Y81_2 Chromatin modification-related protein EAF1 (chains C)
PTIWLSEDDQELVKNINTYGYNWELISAHMTHRLTYSYLSNIERRTPWQCFERFVQLNER
FNFSDLKGPRAHSAQQWLIEAHKFQQRQNRRISPLGVNTESIQRGHRRLRWASMFEAIRK
CMKKRENTPRPNPTQPRKPLDCKNMKVPTPAEMSLLKAQRDEALRRDIQLRRTVKNRLQQ
RQQQSQQAHSSRAQSPIPSNGKSSSNLARNGQASAPRPNQKQYTEQDIIESYSRKLLEQK
PDIGPEMALKAAKNYYRTLREQQQQLKQHQIQQQRQQLQEESSHVQQLQQLQPGSQAPPP
KSSPSQSSLSNISNINSAPRIKSPTPQEILQRFQKQ
Sequence of entity 3 (D), FASTA
>5Y81_3 Eaf1-disorder domain (chains D)
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXX
Sequence of entity 4 (H), FASTA
>5Y81_4 Chromatin modification-related protein EAF5 (chains H)
MDKEVSELVVLQLIHTLISNKNEELVRNGGGINMIGNNLRISLVKLTNEIQNNLLINELT
NLRRQSNVANGNRKLGINDILTIVKNLFPEYRTTLNDGQLSLHGLEMHDIEKLLDEKYDR
FKKTQVEQIRMMEDEILKNGIKTGASQLQPHANAGKSGSAGTSATITTTTPHMAHSMDPK
REKLLKLYRDTVLNKLESKTGNFQKLFKSPDGSIIKNEINYEDIKNETPGSVHELQLILQ
KSITDGVMRKVIGTDDWKLARQVQFELDDTVQFMRRALE
Sequence of entity 5 (A), FASTA
>5Y81_5 Transcription-associated protein 1 (chains A)
MSLTEQIEQFASRFRDDDATLQSRYSTLSELYDIMELLNSPEDYHFFLQAVIPLLLNQLK
EVPISYDAHSPEQKLRNSMLDIFNRCLMNQTFQPYAMEVLEFLLSVLPKENEENGILCMK
VLTTLFKSFKSILQDKLDSFIRIIIQIYKNTPNLINQTFYEAGKAEQGDLDSPKEPQADE
LLDEFSKNDEEKDFPSKQSSTEPRFENSTSSNGLRSSMFSFKILSECPITMVTLYSSYKQ
LTSTSLPEFTPLIMNLLNIQIKQQQEAREQAESRGEHFTSISTEIINRPAYCDFILAQIK
ATSFLAYVFIRGYAPEFLQDYVNFVPDLIIRLLQDCPSELSSARKELLHATRHILSTNYK
KLFLPKLDYLFDERILIGNGFTMHETLRPLAYSTVADFIHNIRSELQLSEIEKTIKIYTG
YLLDESLALTVQIMSAKLLLNLVERILKLGKENPQEAPRAKKLLMIIIDSYMNRFKTLNR
QYDTIMKYYGRYETHKKEKAEKLKNSIQDNDKESEEFMRKVLEPSDDDHLMPQPKKEDIN
DSPDVEMTESDKVVKNDVEMFDIKNYAPILLLPTPTNDPIKDAFYLYRTLMSFLKTIIHD
LKVFNPPPNEYTVANPKLWASVSRVFSYEEVIVFKDLFHECIIGLKFFKDHNEKLSPETT
KKHFDISMPSLPVSATKDARELMDYLAFMFMQMDNATFNEIIEQELPFVYERMLEDSGLL
HVAQSFLTSEITSPNFAGILLRFLKGKLKDLGNVDFNTSNVLIRLFKLSFMSVNLFPNIN
EVVLLPHLNDLILNSLKYSTTAEEPLVYFYLIRTLFRSIGGGRFENLYRSIKPILQVLLQ
SLNQMILTARLPHERELYVELCITVPVRLSVLAPYLPFLMKPLVFALQQYPDLVSQGLRT
LELCIDNLTAEYFDPIIEPVIDDVSKALFNLLQPQPFNHAISHNVVRILGKLGGRNRQFL
KPPTDLTEKTELDIDAIADFKINGMPEDVPLSVTPGIQSALNILQSYKSDIHYRKSAYKY
LTCVLLLMTKSSAEFPTNYTELLKTAVNSIKLERIGIEKNFDLEPTVNKRDYSNQENLFL
RLLESVFYATSIKELKDDAMDLLNNLLDHFCLLQVNTTLLNKRNYNGTFNIDLKNPNFML
DSSLILDAIPFALSYYIPEVREVGVLAYKRIYEKSCLIYGEELALSHSFIPELAKQFIHL
CYDETYYNKRGGVLGIKVLIDNVKSSSVFLKKYQYNLANGLLFVLKDTQSEAPSAITDSA
EKLLIDLLSITFADVKEEDLGNKVLENTLTDIVCELSNANPKVRNACQKSLHTISNLTGI
PIVKLMDHSKQFLLSPIFAKPLRALPFTMQIGNVDAITFCLSLPNTFLTFNEELFRLLQE
SIVLADAEDESLSTNIQKTTEYSTSEQLVQLRIACIKLLAIALKNEEFATAQQGNIRIRI
LAVFFKTMLKTSPEIINTTYEALKGSLAENSKLPKELLQNGLKPLLMNLSDHQKLTVPGL
DALSKLLELLIAYFKVEIGRKLLDHLTAWCRVEVLDTLFGQDLAEQMPTKIIVSIINIFH
LLPPQADMFLNDLLLKVMLLERKLRLQLDSPFRTPLARYLNRFHNPVTEYFKKNMTLRQL
VLFMCNIVQRPEAKELAEDFEKELDNFYDFYISNIPKNQVRVVSFFTNMVDLFNTMVITN
GDEWLKKKGNMILKLKDMLNLTLKTIKENSFYIDHLQLNQSIAKFQALYLRFTELSERDQ
NPLLLDFIDFSFSNGIKASYSLKKFIFHNIIASSNKEKQNNFINDATLFVLSDKCLDARI
FVLKNVINSTLIYEVATSGSLKSYLVEDKKPKWLELLHNKIWKNSNAILAYDVLDHHDLF
RFELLQLSAIFIKADPEIIAEIKKDIIKFCWNFIKLEDTLIKQSAYLVTSYFISKFDFPI
KVVTQVFVALLRSSHVEARYLVKQSLDVLTPVLHERMNAAGTPDTWINWVKRVMVENSSS
QNNILYQFLISHPDLFFNSRDLFISNIIHHMNKITFMSNSNSDSHTLAIDLASLILYWEN
KTLEITNVNNTKTDSDGDVVMSDSKSDINPVEADTTAIIVDANNNSPISLHLREACTAFL
IRYVCASNHRAIETELGLRAINILSELISDKHWTNVNVKLVYFEKFLIFQDLDSENILYY
CMNALDVLYVFFKNKTKEWIMENLPTIQNLLEKCIKSDHHDVQEALQKVLQVIMKAIKAQ
GVSVIIEEESPGKTFIQMLTSVITQDLQETSSVTAGVTLAWVLFMNFPDNIVPLLTPLMK
TFSKLCKDHLSISQPKDAMALEEARITTKLLEKVLYILSLKVSLLGDSRRPFLSTVALLI
DHSMDQNFLRKIVNMSRSWIFNTEIFPTVKEKAAILTKMLAFEIRGEPSLSKLFYEIVLK
LFDQEHFNNTEITVRMEQPFLVGTRVEDIGIRKRFMTILDNSLERDIKERLYYVIRDQNW
EFIADYPWLNQALQLLYGSFNREKELSLKNIYCLSPPSILQEYLPENAEMVTEVNDLELS
NFVKGHIASMQGLCRIISSDFIDSLIEIFYQDPKAIHRAWVTLFPQVYKSIPKNEKYGFV
RSIITLLSKPYHTRQISSRTNVINMLLDSISKIESLELPPHLVKYLA
Sequence of entity 6 (F), FASTA
>5Y81_6 Actin-related protein 4 (chains F)
PMSNAALQVYGGDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGKYTADEGNKKIFSE
QSIGIPRKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTE
NRKKSLEVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKS
TRRNFIAGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFF
QECKETLCHICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLPKEDD
IPANWPRSNSGVVKTWRNDYVPLKRTKPSGVNKSDKKVTPTEEKEQEAVSKSTSPAANSA
DTPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPG
LSDRLMTELNKILPSLKFRILTTGHTIERQYQSWLGGSILTSLGTFHQLWVGKKEYEEVG
VERLLNDRFR
Sequence of entity 7 (G), FASTA
>5Y81_7 Actin (chains G)
MDSEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGIMVGMGQKDSYVGDEAQS
KRGILTLRYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPMNPKSNREKMT
QIMFETFNVPAFYVSIQAVLSLYSSGRTTGIVLDSGDGVTHVVPIYAGFSLPHAILRIDL
AGRDLTDYLMKILSERGYSFSTTAEREIVRDIKEKLCYVALDFEQEMQTAAQSSSIEKSY
ELPDGQVITIGNERFRAPEALFHPSVLGLESAGIDQTTYNSIMKCDVDVRKELYGNIVMS
GGTTMFPGIAERMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLTTFQQMWISKQ
EYDESGPSIVHHKCF
Sequence of entity 8 (E), FASTA
>5Y81_8 Chromatin modification-related protein EAF1 (chains E)
THQNILLEEAKWMQADFKEGHKYKVAICTAMAQAIKDYWTY

Primary citation

Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex. Wang, X., Ahmad, S., Zhang, Z. et al. Nat Commun (2018) 9:1147-1147. DOI 10.1038/s41467-018-03504-5 · PubMed

Other PDB entries of the same protein (UniProt P38811), best resolution first:

Browse structure collections

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