6A6B: Alpha-synuclein fiber

cryo-em structure of alpha-synuclein fiber. Determined by electron microscopy at 3.07 Å resolution. Released 11 Jul 2018.

Method: Electron microscopy
Resolution: 3.07 Å
Organism: Homo sapiens
Chains: 12
Atoms: 5,256
Mol. weight: 75.01 kDa
Released: 11 Jul 2018

Explore 6A6B in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6A6B contains 0 α-helices and 97 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, B, C, D, E, F, G, H, I, J and K: 0 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	46	1	1
β-strand	49-58	10	2
β-strand	61-63	3	3
β-strand	66	1	4
β-strand	71-72	2	5
β-strand	75	1	6
β-strand	80-82	3	7
β-strand	89-92	4	8

Chain L: 0 helices, 9 β-strands

Element	Residues	Length	Sheet
β-strand	46	1	9
β-strand	49-58	10	10
β-strand	61-63	3	11
β-strand	66	1	12
β-strand	71-72	2	13
β-strand	75	1	14
β-strand	80-82	3	15
β-strand	89	1	16
β-strand	92	1	16

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Alpha-synuclein	A, B, C, D, E, F, G, H, I, J, K, L	protein	63	Homo sapiens	P37840 (AlphaFold model)

Sequence of entity 1 (A, B, C, D, E, F, G, H, I, J, K, L), FASTA

>6A6B_1 Alpha-synuclein (chains A, B, C, D, E, F, G, H, I, J, K, L)
VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVK
KDQ

Primary citation

Amyloid fibril structure of alpha-synuclein determined by cryo-electron microscopy. Li, Y., Zhao, C., Luo, F. et al. Cell Res (2018) 28:897-903. DOI 10.1038/s41422-018-0075-x · PubMed

Other PDB entries of the same protein (UniProt P37840 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8JJV 1.23 Å, Structure of truncated form of nanobody in complex with alpha-synuclein peptide
8JLY 1.29 Å, Structure of nanobody in complex with alpha-synuclein peptide
3Q27 1.3 Å, Cyrstal structure of human alpha-synuclein (32-57) fused to maltose binding protein (MBP)
4R0U 1.38 Å, Tgvtava, an amyloid forming segment from alpha synuclein, residues 72-78
6I42 1.38 Å, Structure of the alpha-Synuclein PreNAC/Cyclophilin A-complex
4ZNN 1.41 Å, MicroED structure of the segment, GVVHGVTTVA, from the A53T familial mutant of…
4RIL 1.43 Å, Structure of the amyloid forming segment, GAVVTGVTAVA, from the NAC domain of…
4R0W 1.5 Å, Vvtgvta, an amyloid forming segment from alpha synuclein, residues 70-76
3Q26 1.54 Å, Cyrstal structure of human alpha-synuclein (10-42) fused to maltose binding protein (MBP)
3Q28 1.6 Å, Cyrstal structure of human alpha-synuclein (58-79) fused to maltose binding protein (MBP)
5CRW 1.6 Å, Crystal structure of the b'-a' domain of oxidized protein disulfide isomerase complexed…
2X6M 1.62 Å, Structure of a single domain camelid antibody fragment in complex with a C-terminal…

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6A6B is part of these collections:

Protein folding, misfolding and amyloid

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