X-ray structure of the ts3 human serotonin transporter complexed with fluvoxamine at the central site. Determined by X-ray diffraction at 3.8 Å resolution. Released 25 Oct 2017.
Explore 6AWP in 3D Show helices and sheets RCSB PDB PDBe
6AWP contains 52 α-helices and 48 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 85-96 | 12 | |
| α-helix | 99-110 | 12 | |
| α-helix | 114-117 | 4 | |
| α-helix | 118-124 | 7 | |
| α-helix | 125-129 | 5 | |
| α-helix | 130-143 | 14 | |
| α-helix | 149-152 | 4 | |
| α-helix | 156-158 | 3 | |
| α-helix | 159-188 | 30 | |
| β-strand | 209 | 1 | 1 |
| β-strand | 225 | 1 | 1 |
| α-helix | 227-231 | 5 | |
| α-helix | 232-236 | 5 | |
| α-helix | 239-241 | 3 | |
| β-strand | 251 | 1 | 2 |
| α-helix | 253-267 | 15 | |
| α-helix | 274-301 | 28 | |
| α-helix | 306-313 | 8 | |
| α-helix | 323-337 | 15 | |
| α-helix | 343-349 | 7 | |
| α-helix | 358-389 | 32 | |
| α-helix | 394-397 | 4 | |
| α-helix | 403-404 | 2 | |
| α-helix | 405-410 | 6 | |
| α-helix | 411-415 | 5 | |
| α-helix | 420-453 | 34 | |
| β-strand | 455 | 1 | 3 |
| β-strand | 458 | 1 | 3 |
| α-helix | 462-476 | 15 | |
| β-strand | 482 | 1 | 2 |
| α-helix | 485-491 | 7 | |
| α-helix | 492-496 | 5 | |
| α-helix | 497-514 | 18 | |
| α-helix | 518-528 | 11 | |
| α-helix | 532-534 | 3 | |
| α-helix | 535-539 | 5 | |
| α-helix | 540-544 | 5 | |
| α-helix | 545-558 | 14 | |
| α-helix | 560-563 | 4 | |
| β-strand | 564 | 1 | 4 |
| β-strand | 569 | 1 | 4 |
| α-helix | 570-571 | 2 | |
| α-helix | 574-585 | 12 | |
| α-helix | 588-599 | 12 | |
| α-helix | 604-612 | 9 | |
| α-helix | 614-615 | 2 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 22-25 | 4 | 5 |
| β-strand | 29-31 | 3 | 6 |
| β-strand | 37-44 | 8 | 5 |
| α-helix | 48-50 | 3 | |
| β-strand | 52-58 | 7 | 7 |
| β-strand | 64-71 | 8 | 7 |
| β-strand | 76-79 | 4 | 7 |
| β-strand | 87-92 | 6 | 5 |
| β-strand | 97-102 | 6 | 5 |
| α-helix | 107-109 | 3 | |
| β-strand | 112-118 | 7 | 7 |
| β-strand | 128 | 1 | 7 |
| β-strand | 132-133 | 2 | 7 |
| β-strand | 134-136 | 3 | 6 |
| α-helix | 142-144 | 3 | |
| β-strand | 145-149 | 5 | 8 |
| α-helix | 150-152 | 3 | |
| β-strand | 160-170 | 11 | 8 |
| β-strand | 176-179 | 4 | 9 |
| α-helix | 180-182 | 3 | |
| β-strand | 188-196 | 9 | 8 |
| β-strand | 199-209 | 11 | 8 |
| β-strand | 219-224 | 6 | 9 |
| β-strand | 229-234 | 6 | 9 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 25 | 1 | 10 |
| β-strand | 30-33 | 4 | 11 |
| β-strand | 39-44 | 6 | 10 |
| β-strand | 53-58 | 6 | 11 |
| β-strand | 64-69 | 6 | 11 |
| β-strand | 73-74 | 2 | 11 |
| α-helix | 75 | 1 | |
| β-strand | 82-86 | 5 | 10 |
| β-strand | 90-95 | 6 | 10 |
| α-helix | 100-102 | 3 | |
| β-strand | 105-110 | 6 | 11 |
| α-helix | 116 | 1 | |
| β-strand | 118 | 1 | 11 |
| β-strand | 122-126 | 5 | 11 |
| α-helix | 127 | 1 | |
| β-strand | 131 | 1 | 12 |
| β-strand | 134-138 | 5 | 13 |
| α-helix | 139-141 | 3 | |
| α-helix | 142-147 | 6 | |
| β-strand | 149-159 | 11 | 13 |
| β-strand | 160 | 1 | 12 |
| β-strand | 165-169 | 5 | 14 |
| β-strand | 174-175 | 2 | 14 |
| β-strand | 179-183 | 5 | 13 |
| α-helix | 184-187 | 4 | |
| β-strand | 193-202 | 10 | 13 |
| α-helix | 203-206 | 4 | |
| β-strand | 212-217 | 6 | 14 |
| α-helix | 224 | 1 | |
| β-strand | 225-229 | 5 | 14 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Sodium-dependent serotonin transporter | A | protein | 549 | Homo sapiens | P31645 (AlphaFold model) |
| 8B6 antibody FAB heavy chain | B | protein | 229 | Mus musculus | A0A0F7R1P3 (AlphaFold model) |
| 8B6 antibody FAB light chain | C | protein | 214 | Mus musculus | A0A0F7R5U8 (AlphaFold model) |
>6AWP_1 Sodium-dependent serotonin transporter (chains A) GSQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICAQNGGGAFLLPYTIMAIFGGIPLF YMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTD QLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISW QLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIALSVLLVRGATLPGAWRGVLFYL KPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSF VSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLIT LGLDSSFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLE EYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFII ASFLMSPPQLRLFQYNYPYWSIILGYAIGTSSFICIPTYIAYRLIITPGTFKERIIKSIT PETPTLVPR
>6AWP_2 8B6 antibody FAB heavy chain (chains B) EVQLQQSGPELVKPGASVKISCKASGYTFTDYYMNWVKQSHGKSLEWIGNINPNNGGTSY NQKFKGKATLTVDKSSTTAYMELRSLTSEDSAVYYCTRSPVRPYYFDYWGQGTTLTVSSA KTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGL YTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPRGSHHHHHHHH
>6AWP_3 8B6 antibody FAB light chain (chains C) DIVMTQSHKFMSTSVGDRVSITCKASQDVSTAVAWYQQKPGQSPKLLIYSASYRYTGVPD RFTGSGSGTDFTFTISSVQAEDLAVYYCQQHYSIPRTFGGGTKLEIKRADAAPTVSIFPP SSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLT LTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC
| ID | Name | Formula | Copies |
|---|---|---|---|
| FVX | Fluvoxamine | C15 H21 F3 N2 O2 | 1 |
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 2 |
| CLR | Cholesterol | C27 H46 O | 1 |
Water and common crystallization additives (CL, NA) are not listed.
Structural basis for recognition of diverse antidepressants by the human serotonin transporter. Coleman, J.A., Gouaux, E. Nat Struct Mol Biol (2018) 25:170-175. DOI 10.1038/s41594-018-0026-8 · PubMed
Other PDB entries of the same protein (UniProt P31645 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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