6BVZ: Importin alpha 3 in cargo free state

Importin alpha 3 in cargo free state. Determined by X-ray diffraction at 2.3 Å resolution. Released 4 Jul 2018.

Method: X-ray diffraction
Resolution: 2.3 Å
Organism: Homo sapiens
Chains: 1
Atoms: 3,210
Mol. weight: 50.33 kDa
Released: 4 Jul 2018

Explore 6BVZ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6BVZ contains 32 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 32 helices, 0 β-strands

Element	Residues	Length
α-helix	73-80	8
α-helix	85-100	16
α-helix	107-112	6
α-helix	115-122	8
α-helix	129-143	15
α-helix	147-155	9
α-helix	158-165	8
α-helix	171-187	17
α-helix	189-197	9
α-helix	201-206	6
α-helix	214-229	16
α-helix	234-236	3
α-helix	237-250	14
α-helix	256-270	15
α-helix	274-282	9
α-helix	286-289	4
α-helix	290-294	5
α-helix	298-311	14
α-helix	316-323	8
α-helix	327-330	4
α-helix	332-335	4
α-helix	340-354	15
α-helix	358-366	9
α-helix	370-379	10
α-helix	382-398	17
α-helix	401-409	9
α-helix	413-417	5
α-helix	418-421	4
α-helix	425-441	17
α-helix	446-455	10
α-helix	458-465	8
α-helix	471-484	14

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Importin subunit alpha-3	A	protein	459	Homo sapiens	O00629 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>6BVZ_1 Importin subunit alpha-3 (chains A)
SGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHC
LERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALG
NIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQE
ILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQT
AALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQ
AVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTV
KDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENEDIYKLAYEIID
QFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPTEGFQF

Primary citation

Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Smith, K.M., Tsimbalyuk, S., Edwards, M.R. et al. Nat Commun (2018) 9:3703-3703. DOI 10.1038/s41467-018-05928-5 · PubMed

Other PDB entries of the same protein (UniProt O00629 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6BW9 1.6 Å, Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 1
8HKW 1.9 Å, Crystal structure of importin-alpha3 bound to the 53BP1 nuclear localization signal
7LFC 2.1 Å, Structure of importin a3 bound to p50 NLS
7RG5 2.15 Å, Importin alpha3 in complex with p50 NLS
6BWA 2.2 Å, Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 2
6BVV 2.3 Å, Nipah virus W protein C-terminus in complex with Importin alpha 3
6BWB 2.3 Å, Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 3
6WX8 2.3 Å, SOX2 bound to Importin-alpha 3
7RFY 2.5 Å, Importin alpha3 in complex with MERS ORF4B
7JJL 2.6 Å, Crystal structure of Importin Alpha 3 in complex with human LSD1 NLS
4UAE 2.7 Å, Importin alpha 3 delta IBB in complex with Influenza PB2 Nuclear Localization Domain
8FUB 2.75 Å, Crystal structure of human Importin alpha 3 in complex with Hendra virus matrix protein…

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