6D3B: Neuraminidase

Influenza virus neuraminidase subtype N9 (TERN) apo form. Determined by X-ray diffraction at 1.4 Å resolution. Released 23 Jan 2019.

Method: X-ray diffraction
Resolution: 1.4 Å
Organism: Influenza A virus (strain A/Tern/Australia/G70C/1975 H11N9)
Chains: 1
Atoms: 4,004
Mol. weight: 46.49 kDa
Ligands: NAG, CA
Released: 23 Jan 2019

Explore 6D3B in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6D3B contains 7 α-helices and 30 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 30 β-strands

Element	Residues	Length	Sheet
β-strand	91	1	1
α-helix	92-93	2
β-strand	96-102	7	2
α-helix	105-109	5
β-strand	114	1	3
β-strand	115-125	11	4
β-strand	128-139	12	4
α-helix	143-145	3
β-strand	157-162	6	4
β-strand	168	1	3
α-helix	171	1
β-strand	172-176	5	4
β-strand	179-184	6	5
β-strand	189-195	7	5
β-strand	202-207	6	5
β-strand	210-216	7	5
β-strand	224	1	6
β-strand	233	1	7
β-strand	236	1	7
β-strand	237-244	8	6
β-strand	250-258	9	6
β-strand	261-267	7	6
β-strand	276-283	8	8
β-strand	286-292	7	8
α-helix	300	1
β-strand	301-306	6	8
β-strand	311-316	6	8
α-helix	328-330	3
β-strand	353-354	2	9
β-strand	361-364	4	9
β-strand	372-378	7	9
β-strand	392-403	11	9
β-strand	407-410	4	2
β-strand	418	1	1
β-strand	421-429	9	2
β-strand	439-449	11	2
α-helix	464-467	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Neuraminidase	A	protein	389	Influenza A virus (strain A/Tern/Australia/G70C/1975 H11N9)	P03472

Sequence of entity 1 (A), FASTA

>6D3B_1 Neuraminidase (chains A)
IRDFNNLTKGLCTINSWHIYGKDNAVRIGEDSDVLVTREPYVSCDPDECRFYALSQGTTI
RGKHSNGTIHDRSQYRALISWPLSSPPTVYNSRVECIGWSSTSCHDGKTRMSICISGPNN
NASAVIWYNRRPVTEINTWARNILRTQESECVCHNGVCPVVFTDGSATGPAETRIYYFKE
GKILKWEPLAGTAKHIEECSCYGERAEITCTCRDNWQGSNRPVIRIDPVAMTHTSQYICS
PVLTDNPRPNDPTVGKCNDPYPGNNNNGVKGFSYLDGVNTWLGRTISIASRSGYEMLKVP
NALTDDKSKPTQGQTIVLNTDWSGYSGSFMDYWAEGECYRACFYVELIRGRPKEDKVWWT
SNSIVSMCSSTEFLGQWDWPDGAKIEYFL

Ligands and cofactors

ID	Name	Formula	Copies
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose	C8 H15 N O6	1
CA	Calcium ion	Ca	2

Water and common crystallization additives (GOL) are not listed.

Primary citation

Structure of an Influenza A virus N9 neuraminidase with a tetrabrachion-domain stalk. Streltsov, V.A., Schmidt, P.M., McKimm-Breschkin, J.L. Acta Crystallogr F Struct Biol Commun (2019) 75:89-97. DOI 10.1107/S2053230X18017892 · PubMed

Other PDB entries of the same protein (UniProt P03472), best resolution first:

6HFC 1.29 Å, Influenza A Virus N9 Neuraminidase Native (Tern).
6HCX 1.3 Å, Influenza Virus N9 Neuraminidase A complex with Zanamivir molecule (Tern).
6HG0 1.3 Å, Influenza A Virus N9 Neuraminidase complex with NANA (Tern/Australia).
1F8D 1.4 Å, Native Influenza Neuraminidase in Complex with 9-amino-2-deoxy-2,3-dehydro-N-neuraminic…
1F8E 1.4 Å, Native Influenza Neuraminidase in Complex with 4,9-diamino-2-deoxy-2,3-dehydro-N-acetyl-n…
4DGR 1.55 Å, Influenza Subtype 9 Neuraminidase Benzoic Acid Inhibitor Complex
2QWC 1.6 Å, The X-ray structure of a complex of NEU5AC2EN and a drug resistant variant R292K of tern…
1F8C 1.7 Å, Native Influenza Neuraminidase in Complex with 4-amino-2-deoxy-2,3-dehydro-N-neuraminic…
1MWE 1.7 Å, The X-ray structure of a complex of tern N9 influenza virus neuraminidase complexed with…
2QWA 1.7 Å, The X-ray structure of a drug resistant variant R292K of tern N9 influenza virus…
6HEB 1.75 Å, Influenza A Virus N9 Neuraminidase complex with Oseltamivir (Tern).
1F8B 1.8 Å, Native Influenza Virus Neuraminidase in Complex with NEU5AC2EN

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