6DCV: Human anti-tau antibody CBTAU-27.1

Crystal structure of human anti-tau antibody CBTAU-27.1. Determined by X-ray diffraction at 1.9 Å resolution. Released 6 Jun 2018.

Method: X-ray diffraction
Resolution: 1.9 Å
Organism: Homo sapiens
Chains: 4
Atoms: 7,507
Mol. weight: 99.09 kDa
Released: 6 Jun 2018

Explore 6DCV in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6DCV contains 41 α-helices and 96 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and L: 10 helices, 23 β-strands

Element	Residues	Length	Sheet
β-strand	4-7	4	12
β-strand	10-14	5	13
β-strand	19-25	7	12
β-strand	27C-27D	2	14
β-strand	30-31	2	14
β-strand	33-38	6	13
β-strand	45-49	5	13
β-strand	53-54	2	13
α-helix	55	1
β-strand	62-67	6	12
β-strand	70-75	6	12
α-helix	80-82	3
β-strand	84-90	7	13
α-helix	97	1
β-strand	98	1	13
α-helix	99	1
β-strand	102-107	6	13
β-strand	111	1	15
α-helix	112-113	2
β-strand	114-118	5	16
α-helix	119-121	3
α-helix	122-127	6
β-strand	129-139	11	16
β-strand	140	1	15
β-strand	144-150	7	17
β-strand	153-154	2	17
α-helix	155	1
β-strand	159-163	5	16
α-helix	164-167	4
β-strand	173-182	10	16
α-helix	183-186	4
β-strand	191-198	8	17
β-strand	205-210	6	17

Chain B: 10 helices, 26 β-strands

Element	Residues	Length	Sheet
β-strand	3-6	4	18
β-strand	10-12	3	19
β-strand	18-25	8	18
α-helix	29-31	3
β-strand	32-39	8	19
α-helix	40	1
β-strand	45-52	8	19
β-strand	57-59	3	19
β-strand	64	1	18
β-strand	67-72	6	18
α-helix	73-75	3
β-strand	77-82	6	18
α-helix	84-86	3
β-strand	88-96	9	19
β-strand	99	1	20
β-strand	100A	1	20
β-strand	100E-103	4	19
β-strand	107-111	5	19
α-helix	115-116	2
β-strand	117	1	21
α-helix	118-119	2
β-strand	120-124	5	22
β-strand	133-134	2	22
β-strand	137-147	11	22
β-strand	148	1	21
β-strand	153-157	4	23
α-helix	162-164	3
β-strand	166	1	23
β-strand	171-173	3	22
α-helix	174-176	3
β-strand	177-178	2	22
β-strand	185-194	10	22
α-helix	195-197	3
β-strand	207-212	6	23
α-helix	213-215	3
β-strand	217-222	6	23

Chain H: 11 helices, 24 β-strands

Element	Residues	Length	Sheet
β-strand	3-6	4	7
β-strand	10-12	3	8
β-strand	18-25	8	7
α-helix	29-31	3
β-strand	32-39	8	8
α-helix	40	1
β-strand	45-52	8	8
β-strand	56-59	4	8
β-strand	64	1	7
β-strand	67-72	6	7
α-helix	73-75	3
β-strand	77-82	6	7
α-helix	84-86	3
β-strand	88-96	9	8
β-strand	100E-103	4	8
β-strand	107-111	5	8
α-helix	115-116	2
β-strand	117	1	9
α-helix	118-119	2
β-strand	120-124	5	10
α-helix	128-130	3
β-strand	133-134	2	10
β-strand	137-147	11	10
β-strand	148	1	9
β-strand	153-157	4	11
α-helix	162-164	3
β-strand	166	1	11
β-strand	171-173	3	10
α-helix	174-176	3
β-strand	177-178	2	10
β-strand	185-194	10	10
α-helix	195-197	3
β-strand	207-212	6	11
α-helix	213-215	3
β-strand	217-222	6	11

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Light chain of CBTAU27.1 Fab	A, L	protein	220	Homo sapiens	P01834 (AlphaFold model)
heavy chain of CBTAU-27.1 Fab	B, H	protein	231	Homo sapiens	P01857 (AlphaFold model)

Sequence of entity 1 (A, L), FASTA

>6DCV_1 Light chain of CBTAU27.1 Fab (chains A, L)
DIQLTQSPDSLAVSLGERATINCKSSQSVFSRDNNKNYLAWYQHKSGQPPKLLFFWASSR
ESGVSDRFSGSGSGTDFTLTIDNLQAEDVALYYCQHYFNTPHNFGQGTKLEIKRTVAAPS
VFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYS
LSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

Sequence of entity 2 (B, H), FASTA

>6DCV_2 heavy chain of CBTAU-27.1 Fab (chains B, H)
QVQLVESGPEMRKPGESLKISCKTSGYIFSDYWTAWVRQLPGKGLQWMGIIYSGDSDTRY
HPSVQGHVTMSTDSSLTTAYLQWSSLKASDTGIYYCARLDARVDAGWQLDSWGQGTLVTV
SSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQ
SSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCHHHHHH

Primary citation

A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities. Apetri, A., Crespo, R., Juraszek, J. et al. Acta Neuropathol Commun (2018) 6:43-43. DOI 10.1186/s40478-018-0543-z · PubMed

Other PDB entries of the same protein (UniProt P01834 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5EWI 1.6 Å, Crystal Structure of the Human Fab VRC38.01, an HIV-1 V1V2-Directed Neutralizing…
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6N35 1.75 Å, Anti-HIV-1 Fab 2G12 + Man1-2 re-refinement
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1N0X 1.8 Å, Crystal Structure of a Broadly Neutralizing Anti-HIV-1 Antibody in Complex with a…
3VH8 1.8 Å, KIR3DL1 in complex with HLA-B*5701
3X12 1.8 Å, Crystal structure of HLA-B*57:01.I80N
6B9Z 1.82 Å, Trastuzumab Fab v3
2VXQ 1.9 Å, Crystal structure of the major grass pollen allergen Phl p 2 in complex with its…
3D85 1.9 Å, Crystal structure of IL-23 in complex with neutralizing FAB
6BAH 1.9 Å, Trastuzumab Fab v3 with 5-diphenyl meditope variant
1GAF 1.95 Å, 48G7 hybridoma line FAB complexed with hapten 5-(para-nitrophenyl phosphonate)-pentanoic…

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