6G6J: Human MYC:MAX bHLHZip complex

The crystal structures of Human MYC:MAX bHLHZip complex. Determined by X-ray diffraction at 2.25 Å resolution. Released 10 Apr 2019.

Method: X-ray diffraction
Resolution: 2.25 Å
Organism: Homo sapiens
Chains: 4
Atoms: 2,747
Mol. weight: 43.4 kDa
Released: 10 Apr 2019

Explore 6G6J in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6G6J contains 10 α-helices and 0 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	906-925	20
α-helix	939-982	44

Chain B: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	211-228	18
α-helix	230-232	3
α-helix	239-279	41

Chain C: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	908-925	18
α-helix	939-982	44

Chain D: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	213-228	16
α-helix	230-232	3
α-helix	239-280	42

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Myc proto-oncogene protein	A, C	protein	94	Homo sapiens	P01106 (AlphaFold model)
Protein max	B, D	protein	83	Homo sapiens	P61244 (AlphaFold model)

Sequence of entity 1 (A, C), FASTA

>6G6J_1 Myc proto-oncogene protein (chains A, C)
MHHHHHHEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYI
LSVQAEEQKLISEEDLLRKRREQLKHKLEQLRNS

Sequence of entity 2 (B, D), FASTA

>6G6J_2 Protein max (chains B, D)
MADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILDKATEYIQYMRRKNHT
HQQDIDDLKRQNALLEQQVRALE

Primary citation

Crystal Structures and Nuclear Magnetic Resonance Studies of the Apo Form of the c-MYC:MAX bHLHZip Complex Reveal a Helical Basic Region in the Absence of DNA. Sammak, S., Hamdani, N., Gorrec, F. et al. Biochemistry (2019) 58:3144-3154. DOI 10.1021/acs.biochem.9b00296 · PubMed

Other PDB entries of the same protein (UniProt P01106 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9QNH 1.3 Å, Myc pS294 phosphopeptide binding to 14-3-3sigma
6G6K 1.35 Å, The crystal structures of Human MYC:MAX bHLHZip complex
1NKP 1.8 Å, Crystal structure of Myc-Max recognizing DNA
8Q1N 1.84 Å, Cyclic peptide binder of the WBM-site of WDR5
4Y7R 1.9 Å, Crystal structure of WDR5 in complex with MYC MbIIIb peptide
8J2Q 1.92 Å, Crystal structure of Cypovirus Polyhedra mutant fused with c-Myc fragment
5I4Z 1.95 Å, Structure of apo OmoMYC
8X8V 2.0 Å, Crystal structure of Cypovirus Polyhedra mutant fused with c-Myc fragment
8X8S 2.04 Å, Crystal structure of Cypovirus Polyhedra mutant fused with c-Myc fragment
1EE4 2.1 Å, Crystal structure of yeast karyopherin (importin) alpha in a complex with a C-myc nls…
6G6L 2.2 Å, The crystal structures of Human MYC:MAX bHLHZip complex
6E16 2.4 Å, Ternary structure of c-Myc-TBP-TAF1

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