pVHL:EloB:EloC in complex with modified HIF-1a CODD peptide containing (3R,4S)-3-fluoro-4-hydroxyproline (ligand 13a). Determined by X-ray diffraction at 1.83 Å resolution. Released 11 Jul 2018.
Explore 6GFX in 3D Show helices and sheets RCSB PDB PDBe
6GFX contains 22 α-helices and 27 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 2-9 | 8 | 1 |
| β-strand | 10 | 1 | 2 |
| β-strand | 12-19 | 8 | 1 |
| β-strand | 23 | 1 | 3 |
| α-helix | 24-35 | 12 | |
| α-helix | 39-41 | 3 | |
| β-strand | 42-46 | 5 | 1 |
| β-strand | 49-50 | 2 | 1 |
| α-helix | 51-52 | 2 | |
| β-strand | 56 | 1 | 3 |
| α-helix | 64-66 | 3 | |
| β-strand | 68 | 1 | 4 |
| β-strand | 71 | 1 | 4 |
| α-helix | 72 | 1 | |
| β-strand | 73-79 | 7 | 1 |
| α-helix | 86-88 | 3 | |
| β-strand | 90 | 1 | 2 |
| α-helix | 96-100 | 5 | |
| α-helix | 101-103 | 3 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 18-22 | 5 | 1 |
| β-strand | 28-32 | 5 | 1 |
| α-helix | 33-36 | 4 | |
| α-helix | 40-46 | 7 | |
| β-strand | 59-61 | 3 | 1 |
| α-helix | 67-83 | 17 | |
| α-helix | 89-92 | 4 | |
| α-helix | 97-99 | 3 | |
| α-helix | 100-110 | 11 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 71-78 | 8 | 5 |
| α-helix | 83 | 1 | |
| β-strand | 84-89 | 6 | 6 |
| β-strand | 95-97 | 3 | 6 |
| β-strand | 101 | 1 | 6 |
| β-strand | 105-112 | 8 | 5 |
| β-strand | 116-121 | 6 | 6 |
| β-strand | 127 | 1 | 6 |
| β-strand | 129-130 | 2 | 5 |
| β-strand | 133 | 1 | 5 |
| β-strand | 136 | 1 | 6 |
| α-helix | 140-141 | 2 | |
| α-helix | 142-144 | 3 | |
| α-helix | 145-146 | 2 | |
| β-strand | 147-152 | 6 | 5 |
| α-helix | 158-169 | 12 | |
| α-helix | 172-177 | 6 | |
| α-helix | 183-189 | 7 | |
| α-helix | 194-206 | 13 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 565 | 1 | 5 |
| β-strand | 572-573 | 2 | 5 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Elongin-B | A | protein | 104 | Homo sapiens | Q15370 (AlphaFold model) |
| Elongin-C | B | protein | 97 | Homo sapiens | Q15369 (AlphaFold model) |
| von Hippel-Lindau disease tumor suppressor | C | protein | 160 | Homo sapiens | P40337 (AlphaFold model) |
| Fluorinated hypoxia-inducible factor 1 alpha peptide | D | protein | 19 | Homo sapiens | Q16665 (AlphaFold model) |
>6GFX_1 Elongin-B (chains A) MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGEC GFTSQTARPQAPATVGLAFRADDTFEALCIEPFSSPPELPDVMK
>6GFX_2 Elongin-C (chains B) MMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCM YFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC
>6GFX_3 von Hippel-Lindau disease tumor suppressor (chains C) MEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYR GHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPE NYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
>6GFX_4 FLUORINATED HYPOXIA-INDUCIBLE FACTOR 1 ALPHA PEPTIDE (chains D) DEALAXYIPMDDDFQLRSF
3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation. Testa, A., Lucas, X., Castro, G.V. et al. J Am Chem Soc (2018) 140:9299-9313. DOI 10.1021/jacs.8b05807 · PubMed
Other PDB entries of the same protein (UniProt Q15370 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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