Crystal Structure of the first bromodomain of BRD4 in complex with RT56. Determined by X-ray diffraction at 1.0 Å resolution. Released 27 Nov 2019.
Explore 6I7Y in 3D Show helices and sheets RCSB PDB PDBe
6I7Y contains 10 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 43-49 | 7 | |
| α-helix | 61-65 | 5 | |
| α-helix | 66-71 | 6 | |
| α-helix | 72-75 | 4 | |
| α-helix | 81-83 | 3 | |
| α-helix | 97-100 | 4 | |
| α-helix | 107-115 | 9 | |
| α-helix | 122-139 | 18 | |
| α-helix | 145-161 | 17 | |
| α-helix | 164-167 | 4 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Bromodomain-containing protein 4 | A | protein | 127 | Homo sapiens | O60885 (AlphaFold model) |
>6I7Y_1 Bromodomain-containing protein 4 (chains A) SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKII KTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI NELPTEE
| ID | Name | Formula | Copies |
|---|---|---|---|
| H7E | [1-[4-[2-[(4~{S})-6-(4-chlorophenyl)-8-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4… | C34 H39 Cl N7 O2 | 1 |
Water and common crystallization additives (EDO) are not listed.
Crystal Structure of the first bromodomain of BRD4 in complex with RT56. Picaud, S., Traquete, R., Bernardes, G.J.L. et al. To be published.
Other PDB entries of the same protein (UniProt O60885 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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