Bromodomain-containing protein 4 (BRD4) is a 1362-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O60885.
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The mean pLDDT of this model is 55.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 18% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 61% |
What pLDDT means and how to read it
Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:20871596, PubMed:23086925, PubMed:23317504, PubMed:29176719, PubMed:29379197). Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:22334664, PubMed:23317504, PubMed:23589332). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and…
Interacts with p53/TP53; the interaction is direct (PubMed:23317504). Interacts (via CTD region) with CDK9 and CCNT1, acting as an associated component of P-TEFb complex (PubMed:16109376, PubMed:16109377, PubMed:23317504, PubMed:24360279). Interacts with RELA (when acetylated at 'Lys-310') (PubMed:19103749). Interacts (via NET domain) with NSD3, CHD4, BICRA and ATAD5 (PubMed:21555454,…
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4QB3 | X-ray | 0.94 Å | A=44-168 |
| 6FO5 | X-ray | 0.95 Å | A=44-168 |
| 4ZC9 | X-ray | 0.99 Å | A=44-168 |
| 7Z9W | X-ray | 0.99 Å | AAA=44-168 |
| 6I7Y | X-ray | 1.0 Å | A=44-168 |
| 7ZAJ | X-ray | 1.0 Å | AAA=44-168 |
| 8YMF | X-ray | 1.01 Å | A=44-168 |
| 8YMG | X-ray | 1.01 Å | A=44-168 |
| 8YMI | X-ray | 1.01 Å | A=44-168 |
| 7Z9Y | X-ray | 1.04 Å | AAA=44-168 |
| 7ZA8 | X-ray | 1.04 Å | AAA=44-168 |
| 7ZE6 | X-ray | 1.04 Å | A=44-168 |
| 8YMH | X-ray | 1.04 Å | A=44-168 |
| 5EI4 | X-ray | 1.05 Å | A=44-168 |
| 6YQN | X-ray | 1.05 Å | A=44-168 |
| 7RN2 | X-ray | 1.05 Å | A=44-168 |
| 7ZA9 | X-ray | 1.05 Å | AAA=44-168 |
| 4Z1S | X-ray | 1.06 Å | A/B=42-166 |
| 7ZA7 | X-ray | 1.06 Å | AAA=44-168 |
| 6XUZ | X-ray | 1.07 Å | A=44-168 |
Showing 20 of 618 experimental structures (best resolution first).
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