6MUD: Calmodulin-1

Voltage-gated sodium channel NaV1.5 C-terminal domain in complex with Ca2+/Calmodulin. Determined by X-ray diffraction at 2.69 Å resolution. Released 8 May 2019.

Method: X-ray diffraction
Resolution: 2.69 Å
Organism: Homo sapiens
Chains: 2
Atoms: 2,233
Mol. weight: 33.27 kDa
Ligands: CA
Released: 8 May 2019

Explore 6MUD in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6MUD contains 18 α-helices and 10 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 6 β-strands

Element	Residues	Length	Sheet
α-helix	6-19	14
β-strand	27	1	1
α-helix	29-38	10
α-helix	45-55	11
β-strand	63	1	1
α-helix	65-79	15
α-helix	81-92	12
β-strand	100	1	2
α-helix	102-108	7
β-strand	111	1	3
β-strand	114	1	3
α-helix	115-117	3
α-helix	118-128	11
β-strand	136	1	2
α-helix	138-143	6

Chain B: 9 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	1788-1801	14
β-strand	1808-1810	3	4
α-helix	1811-1813	3
α-helix	1814-1820	7
α-helix	1822	1
α-helix	1828	1
α-helix	1832-1837	6
β-strand	1841-1842	2	5
β-strand	1847-1849	3	4
α-helix	1850-1862	13
α-helix	1866-1877	12
β-strand	1893-1894	2	5
α-helix	1895-1917	23

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin-1	A	protein	149	Homo sapiens	P0DP24 (AlphaFold model)
Sodium channel protein type 5 subunit alpha	B	protein	140	Homo sapiens	Q14524 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>6MUD_1 Calmodulin-1 (chains A)
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 2 (B), FASTA

>6MUD_2 Sodium channel protein type 5 subunit alpha (chains B)
SNALSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPM
VSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEE
VSAMVIQRAFRRHLLQRSLK

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	4

Primary citation

Crystal structures of Ca2+-calmodulin bound to NaVC-terminal regions suggest role for EF-hand domain in binding and inactivation. Gardill, B.R., Rivera-Acevedo, R.E., Tung, C.C. et al. Proc Natl Acad Sci U S A (2019) 116:10763-10772. DOI 10.1073/pnas.1818618116 · PubMed

Other PDB entries of the same protein (UniProt P0DP24 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6XXF 1.7 Å, 1.7 Angstrom crystal structure of Ca/CaM:RyR2 peptide complex
6SZ5 2.23 Å, Human calmodulin bound to a peptide of human NADPH oxidase 5
3O77 2.35 Å, The structure of Ca2+ Sensor (Case-16)
8KA0 2.35 Å, Crystal structure of Vibrio vulnificus RID-dependent transforming NADase domain…
7MIR 2.5 Å, Cryo-EM structure of SidJ-SdeA-CaM reaction intermediate complex
6PLM 2.59 Å, Legionella pneumophila SidJ/ Calmodulin 2 complex
3O78 2.6 Å, The structure of Ca2+ Sensor (Case-12)
5COC 2.67 Å, Fusion protein of human calmodulin and B4 domain of protein A from staphylococcal aureus
7MIS 2.8 Å, Cryo-EM structure of SidJ-SdeC-CaM reaction intermediate complex
8KA1 2.82 Å, Crystal structure of Vibrio vulnificus RID-dependent transforming NADase domain…
8K9Z 2.9 Å, Crystal structure of Vibrio vulnificus RID-dependent transforming NADase domain…
7PPO 2.91 Å, Structure of SidJ/CaM bound to SdeA in pre-glutamylation state

Browse structure collections

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