6XXF: Calmodulin-2

1.7 Angstrom crystal structure of Ca/CaM:RyR2 peptide complex. Determined by X-ray diffraction at 1.7 Å resolution. Released 10 Feb 2021.

Method: X-ray diffraction
Resolution: 1.7 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,456
Mol. weight: 19.52 kDa
Ligands: CA
Released: 10 Feb 2021

Explore 6XXF in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6XXF contains 9 α-helices and 4 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain AAA: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	7-20	14
β-strand	27-28	2	1
α-helix	30-39	10
α-helix	46-56	11
β-strand	64-65	2	1
α-helix	66-76	11
α-helix	82-93	12
β-strand	101	1	2
α-helix	103-112	10
α-helix	119-129	11
β-strand	137	1	2
α-helix	139-146	8

Chain BBB: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	2-18	17

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin-2	AAA	protein	149	Homo sapiens	P0DP24 (AlphaFold model)
RyR2 Peptide	BBB	protein	21	Homo sapiens

Sequence of entity 1 (AAA), FASTA

>6XXF_1 Calmodulin-2 (chains AAA)
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 2 (BBB), FASTA

>6XXF_2 RyR2 Peptide (chains BBB)
KKAVWHKLLSKQRKRAVVACF

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	4

Primary citation

CPVT-associated calmodulin variants N53I and A102V dysregulate Ca2+ signalling via different mechanisms. Prakash, O., Held, M., McCormick, L.F. et al. J Cell Sci (2022) 135. DOI 10.1242/jcs.258796 · PubMed

Other PDB entries of the same protein (UniProt P0DP24 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6SZ5 2.23 Å, Human calmodulin bound to a peptide of human NADPH oxidase 5
3O77 2.35 Å, The structure of Ca2+ Sensor (Case-16)
8KA0 2.35 Å, Crystal structure of Vibrio vulnificus RID-dependent transforming NADase domain…
7MIR 2.5 Å, Cryo-EM structure of SidJ-SdeA-CaM reaction intermediate complex
6PLM 2.59 Å, Legionella pneumophila SidJ/ Calmodulin 2 complex
3O78 2.6 Å, The structure of Ca2+ Sensor (Case-12)
5COC 2.67 Å, Fusion protein of human calmodulin and B4 domain of protein A from staphylococcal aureus
6MUD 2.69 Å, Voltage-gated sodium channel NaV1.5 C-terminal domain in complex with Ca2+/Calmodulin
7MIS 2.8 Å, Cryo-EM structure of SidJ-SdeC-CaM reaction intermediate complex
8KA1 2.82 Å, Crystal structure of Vibrio vulnificus RID-dependent transforming NADase domain…
8K9Z 2.9 Å, Crystal structure of Vibrio vulnificus RID-dependent transforming NADase domain…
7PPO 2.91 Å, Structure of SidJ/CaM bound to SdeA in pre-glutamylation state

Browse structure collections

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