6N6R: ABIN-1 UBAN

Crystal structure of ABIN-1 UBAN in complex with two M1-linked di-ubiquitins. Determined by X-ray diffraction at 1.95 Å resolution. Released 17 Jul 2019.

Method: X-ray diffraction
Resolution: 1.95 Å
Organisms: Homo sapiens, Mus musculus
Chains: 4
Atoms: 3,653
Mol. weight: 52.05 kDa
Released: 17 Jul 2019

Explore 6N6R in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6N6R contains 16 α-helices and 28 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 14 β-strands

Element	Residues	Length	Sheet
β-strand	2-6	5	1
β-strand	12-16	5	1
β-strand	22	1	2
α-helix	23-34	12
α-helix	38-40	3
β-strand	41-45	5	1
β-strand	48-49	2	1
α-helix	50-51	2
β-strand	55	1	2
α-helix	57-59	3
β-strand	66-71	6	1
β-strand	77-83	7	3
β-strand	88-93	6	3
β-strand	98	1	4
α-helix	99-110	12
α-helix	114-116	3
β-strand	117-121	5	3
β-strand	124-125	2	3
α-helix	126-127	2
β-strand	131	1	4
α-helix	133-135	3
β-strand	142-147	6	3

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	465-529	65

Chain C: 6 helices, 14 β-strands

Element	Residues	Length	Sheet
β-strand	2-7	6	5
β-strand	12-16	5	5
β-strand	22	1	6
α-helix	23-33	11
α-helix	38-40	3
β-strand	41-45	5	5
β-strand	48-49	2	5
β-strand	55	1	6
β-strand	66-71	6	5
β-strand	77-83	7	7
β-strand	88-93	6	7
β-strand	98	1	8
α-helix	99-110	12
α-helix	114-116	3
β-strand	117-121	5	7
β-strand	124-125	2	7
α-helix	126-127	2
β-strand	131	1	8
α-helix	133-135	3
β-strand	142-147	6	7

Chain D: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	466-530	65

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Ubiquitin	A, C	protein	157	Homo sapiens	P0CG48 (AlphaFold model)
TNFAIP3-interacting protein 1	B, D	protein	70	Mus musculus	Q9WUU8 (AlphaFold model)

Sequence of entity 1 (A, C), FASTA

>6N6R_1 Ubiquitin (chains A, C)
GSGSGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRT
LSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPD
QQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG

Sequence of entity 2 (B, D), FASTA

>6N6R_2 TNFAIP3-interacting protein 1 (chains B, D)
LRKQELVTQNELLKQQVKIFEEDFQRERSDRERMNEEKEELKKQVEKLQAQVTLTNAQLK
TLKEEEKAKE

Primary citation

Molecular Recognition of M1-Linked Ubiquitin Chains by Native and Phosphorylated UBAN Domains. Herhaus, L., van den Bedem, H., Tang, S. et al. J Mol Biol (2019) 431:3146-3156. DOI 10.1016/j.jmb.2019.06.012 · PubMed

Other PDB entries of the same protein (UniProt P0CG48 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6Q00 0.85 Å, TDP2 UBA Domain Bound to Ubiquitin at 0.85 Angstroms Resolution, Crystal Form 1
1OGW 1.32 Å, Synthetic Ubiquitin with fluoro-Leu at 50 and 67
5NL4 1.32 Å, Crystal structure of Zn1.3-E16V human ubiquitin (hUb) mutant adduct, from a solution 35…
2GBJ 1.35 Å, Crystal Structure of the 9-10 8 Glycine Insertion Mutant of Ubiquitin.
4HK2 1.4 Å, U7Ub25.2540
9FJ3 1.4 Å, Structure of ubiquitin bound of coiled-coil UIM form 2
1XD3 1.45 Å, Crystal structure of UCHL3-UbVME complex
4IUM 1.45 Å, Equine arteritis virus papain-like protease 2 (PLP2) covalently bound to ubiquitin
7UV5 1.45 Å, The crystal structure of Papain-Like Protease of SARS CoV-2, C111S/D286N mutant, in…
5NLF 1.5 Å, Crystal structure of Zn2.7-E16V human ubiquitin (hUb) mutant adduct, from a solution 100…
9F6G 1.5 Å, Human USP30 chimera bound to Ubiquitin-PA
9OVX 1.5 Å, Crystal structure of ubiquitin K27M mutant

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