6NSV: Human CHIP TPR domain

Name: PDB 6NSV: Crystal structure of the human CHIP TPR domain in complex with a 5mer acetylated optimized peptide
Published: 2019-07-31
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: ligase

Crystal structure of the human CHIP TPR domain in complex with a 5mer acetylated optimized peptide. Determined by X-ray diffraction at 1.3 Å resolution. Released 31 Jul 2019.

Method: X-ray diffraction
Resolution: 1.3 Å
Organisms: Homo sapiens, synthetic construct
Chains: 4
Atoms: 2,447
Mol. weight: 31.86 kDa
Released: 31 Jul 2019

Explore 6NSV in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6NSV contains 14 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 0 β-strands

Element	Residues	Length
α-helix	26-38	13
α-helix	42-55	14
α-helix	60-72	13
α-helix	76-89	14
α-helix	94-106	13
α-helix	110-126	17
α-helix	134-149	16

Chain B: 7 helices, 0 β-strands

Element	Residues	Length
α-helix	26-38	13
α-helix	42-55	14
α-helix	60-72	13
α-helix	76-89	14
α-helix	94-106	13
α-helix	110-126	17
α-helix	134-151	18

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
E3 ubiquitin-protein ligase CHIP	A, B	protein	130	Homo sapiens	Q9UNE7 (AlphaFold model)
Ace-leu-trp-trp-pro-asp	C, D	protein	6	synthetic construct

Sequence of entity 1 (A, B), FASTA

>6NSV_1 E3 ubiquitin-protein ligase CHIP (chains A, B)
SPSAQELKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRALCYLKMQQHEQALAD
CRRALELDGQSVKAHFFLGQCQLEMESYDEAIANLQRAYSLAKEQRLNFGDDIPSALRIA
KKKRWNSIEE

Sequence of entity 2 (C, D), FASTA

>6NSV_2 ACE-LEU-TRP-TRP-PRO-ASP (chains C, D)
XLWWPD

Primary citation

Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases. Ravalin, M., Theofilas, P., Basu, K. et al. Nat Chem Biol (2019) 15:786-794. DOI 10.1038/s41589-019-0322-6 · PubMed

Other PDB entries of the same protein (UniProt Q9UNE7 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9QFY 1.06 Å, Structure of CHIP E3 ubiquitin ligase TPR domain in complex with compound 9.
9QFS 1.33 Å, Structure of CHIP E3 ubiquitin ligase TPR domain in complex with compound 8.
9QEU 1.35 Å, Structure of CHIP E3 ubiquitin ligase TPR domain in complex with compound 1
8GCK 1.37 Å, Crystal structure of the human CHIP-TPR domain in complex with a 6mer acetylated tau…
8EI0 1.47 Å, Crystal structure of the STUB1 TPR domain in complex with H318, a Helicon Polypeptide
6EFK 1.5 Å, Crystal structure of the human CHIP TPR domain in complex with a 5mer acetylated HSP70…
9QF1 1.51 Å, Structure of CHIP E3 ubiquitin ligase TPR domain in complex with compound 2
8F16 1.56 Å, Structure of the STUB1 TPR domain in complex with H203, an all-D Helicon Polypeptide
9DYB 1.6 Å, CHIP-TPR in complex with the phosphorylated Hsp70 tail
8SUV 1.63 Å, CHIP-TPR in complex with the C-terminus of CHIC2
8F14 1.69 Å, Structure of the STUB1 TPR domain in complex with H201, an all-D Helicon Polypeptide
8F15 1.73 Å, Structure of the STUB1 TPR domain in complex with H202, an all-D Helicon Polypeptide

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