6O4J: Amyloid-beta precursor protein
Amyloid Beta KLVFFAENVGS 16-26 D23N Iowa mutation. Determined by electron crystallography at 1.4 Å resolution. Released 30 Oct 2019.
- Method
- Electron crystallography
- Resolution
- 1.4 Å
- Organism
- Homo sapiens
- Chains
- 2
- Atoms
- 178
- Mol. weight
- 2.47 kDa
- Released
- 30 Oct 2019
Explore 6O4J in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
6O4J contains 0 α-helices and 2 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chains A and B: 0 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| β-strand | 17-20 | 4 | 1 |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Amyloid-beta precursor protein | A, B | protein | 13 | Homo sapiens | P05067 (AlphaFold model) |
Sequence of entity 1 (A, B), FASTA
>6O4J_1 Amyloid-beta precursor protein (chains A, B)
XKLVFFAENVGSX
Primary citation
Structure based inhibitors of Amyloid Beta core suggest a common interface with Tau. Griner, S.L., Seidler, P., Bowler, J. et al. Elife (2019) 8. DOI 10.7554/eLife.46924 · PubMed
Other PDB entries of the same protein (UniProt P05067 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 2FMA 0.85 Å, Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in…
- 6NB9 1.05 Å, Amyloid-Beta (20-34) with L-isoaspartate 23
- 6OIZ 1.1 Å, Amyloid-Beta (20-34) wild type
- 8T82 1.1 Å, Racemic mixture of amyloid beta segment 35-MVGGVV-40 forms heterochiral rippled…
- 5ONQ 1.17 Å, Alzheimer's Amyloid-Beta Peptide Fragment 29-40 in Complex with Cd-substituted Thermolysin
- 3JQL 1.2 Å, Crystal Structure of the Complex Formed Between Phospholipase A2 and a Hexapeptide…
- 3PZZ 1.29 Å, Structure of an amyloid forming peptide GAIIGL (29-34) from amyloid beta
- 4PQD 1.33 Å, The longer crystal structure of the grow factor like domain from Beta amypoid precusor…
- 5ONP 1.34 Å, Alzheimer's Amyloid-Beta Peptide Fragment 1-40 in Complex with Cd-substituted Thermolysin
- 5ONR 1.39 Å, Alzheimer's Amyloid-Beta Peptide Fragment 1-40 in Complex with Thermolysin
- 4PWQ 1.4 Å, High-resolution crystal structure of the E1-domain of the amyloid precursor protein
- 7OW1 1.4 Å, Crystal Structure of TAP01 in complex with amyloid beta peptide
Browse structure collections
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