6SB0: MTORC1

cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases. Determined by electron microscopy at 5.5 Å resolution. Released 16 Oct 2019.

Method: Electron microscopy
Resolution: 5.5 Å
Organism: Homo sapiens
Chains: 12
Atoms: 41,284
Mol. weight: 1162.77 kDa
Ligands: GTP, GDP
Released: 16 Oct 2019

Explore 6SB0 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6SB0 contains 429 α-helices and 232 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 139 helices, 15 β-strands

Element	Residues	Length	Sheet
α-helix	19-29	11
α-helix	39-52	14
α-helix	61-72	12
α-helix	83-90	8
α-helix	102-114	13
α-helix	122-134	13
α-helix	141-155	15
α-helix	165-178	14
α-helix	180-183	4
α-helix	184-186	3
α-helix	188-197	10
α-helix	204-222	19
α-helix	234-245	12
α-helix	259-262	4
α-helix	264-275	12
α-helix	277-288	12
α-helix	362-375	14
α-helix	387-402	16
α-helix	411-425	15
α-helix	430-443	14
α-helix	447-451	5
α-helix	452-462	11
α-helix	479-490	12
α-helix	499-511	13
α-helix	515-527	13
α-helix	532-548	17
α-helix	579-591	13
α-helix	601-612	12
α-helix	616-629	14
α-helix	648-665	18
α-helix	669-678	10
α-helix	681-683	3
α-helix	684-687	4
α-helix	690-699	10
α-helix	705-717	13
α-helix	723-742	20
α-helix	747-763	17
α-helix	765-768	4
α-helix	772-783	12
α-helix	792-808	17
α-helix	817-828	12
α-helix	837-847	11
α-helix	848-852	5
α-helix	856-860	5
α-helix	864-871	8
α-helix	878-890	13
α-helix	896-902	7
α-helix	934-940	7
α-helix	943-958	16
α-helix	964-982	19
α-helix	985-989	5
α-helix	990-1003	14
α-helix	1006-1008	3
α-helix	1009-1023	15
α-helix	1024-1030	7
α-helix	1031-1041	11
α-helix	1046-1063	18
α-helix	1064-1069	6
α-helix	1071-1083	13
α-helix	1088-1090	3
α-helix	1091-1103	13
α-helix	1104-1110	7
α-helix	1111-1123	13
α-helix	1129-1143	15
α-helix	1152-1165	14
α-helix	1170-1184	15
α-helix	1185-1191	7
α-helix	1192-1202	11
α-helix	1207-1218	12
α-helix	1263-1269	7
α-helix	1277-1294	18
α-helix	1298-1301	4
α-helix	1304-1309	6
α-helix	1311-1316	6
α-helix	1318-1328	11
α-helix	1332-1346	15
α-helix	1351-1366	16
α-helix	1380-1389	10
α-helix	1393-1406	14
α-helix	1410-1422	13
α-helix	1426-1439	14
α-helix	1447-1452	6
α-helix	1456-1469	14
α-helix	1474-1487	14
α-helix	1490-1499	10
α-helix	1506-1523	18
α-helix	1526-1535	10
α-helix	1541-1553	13
α-helix	1557-1578	22
α-helix	1587-1607	21
α-helix	1609-1611	3
α-helix	1612-1625	14
α-helix	1630-1640	11
α-helix	1646-1648	3
α-helix	1650-1662	13
α-helix	1666-1677	12
α-helix	1688-1690	3
α-helix	1694-1706	13
α-helix	1710-1731	22
α-helix	1738-1761	24
α-helix	1768-1782	15
α-helix	1787-1808	22
α-helix	1809-1813	5
α-helix	1869-1893	25
α-helix	1900-1913	14
α-helix	1917-1929	13
α-helix	1934-1938	5
α-helix	1939-1944	6
α-helix	1951-1966	16
α-helix	1973-1980	8
α-helix	1985-1999	15
α-helix	2004-2020	17
α-helix	2023-2035	13
α-helix	2036-2041	6
α-helix	2044-2058	15
α-helix	2065-2073	9
α-helix	2075-2089	15
α-helix	2094-2114	21
α-helix	2115-2117	3
β-strand	2120-2122	3	1
α-helix	2123-2126	4
α-helix	2128-2132	5
β-strand	2134	1	2
β-strand	2139	1	3
β-strand	2152	1	3
β-strand	2153-2156	4	2
β-strand	2159-2161	3	1
β-strand	2170	1	4
β-strand	2173-2176	4	2
β-strand	2181-2183	3	2
β-strand	2184-2187	4	4
α-helix	2193-2211	19
α-helix	2213-2218	6
β-strand	2227-2229	3	4
β-strand	2235-2238	4	4
α-helix	2239-2240	2
β-strand	2243-2245	3	5
α-helix	2246-2256	11
α-helix	2263-2271	9
α-helix	2275-2277	3
α-helix	2280-2292	13
α-helix	2298-2305	8
α-helix	2311-2334	24
β-strand	2344-2347	4	5
β-strand	2353-2355	3	5
α-helix	2364-2367	4
α-helix	2381-2385	5
α-helix	2395-2409	15
α-helix	2411-2422	12
α-helix	2429-2432	4
α-helix	2493-2509	17
α-helix	2521-2533	13
α-helix	2535-2540	6
α-helix	2543-2545	3

Chain B: 139 helices, 15 β-strands

Element	Residues	Length	Sheet
α-helix	19-29	11
α-helix	39-52	14
α-helix	61-72	12
α-helix	83-93	11
α-helix	102-114	13
α-helix	122-134	13
α-helix	141-155	15
α-helix	165-178	14
α-helix	180-183	4
α-helix	184-186	3
α-helix	188-197	10
α-helix	204-222	19
α-helix	234-245	12
α-helix	259-262	4
α-helix	264-275	12
α-helix	277-288	12
α-helix	362-375	14
α-helix	387-402	16
α-helix	411-425	15
α-helix	430-443	14
α-helix	447-451	5
α-helix	452-462	11
α-helix	479-490	12
α-helix	499-511	13
α-helix	515-527	13
α-helix	532-548	17
α-helix	579-591	13
α-helix	601-612	12
α-helix	616-629	14
α-helix	648-665	18
α-helix	669-678	10
α-helix	681-683	3
α-helix	684-687	4
α-helix	690-699	10
α-helix	705-717	13
α-helix	723-742	20
α-helix	747-763	17
α-helix	765-768	4
α-helix	772-783	12
α-helix	792-808	17
α-helix	817-828	12
α-helix	837-847	11
α-helix	848-852	5
α-helix	856-860	5
α-helix	864-871	8
α-helix	878-890	13
α-helix	896-902	7
α-helix	934-940	7
α-helix	943-958	16
α-helix	964-982	19
α-helix	985-989	5
α-helix	990-1003	14
α-helix	1006-1008	3
α-helix	1009-1023	15
α-helix	1024-1030	7
α-helix	1031-1041	11
α-helix	1046-1063	18
α-helix	1064-1069	6
α-helix	1071-1083	13
α-helix	1088-1090	3
α-helix	1091-1103	13
α-helix	1104-1109	6
α-helix	1111-1123	13
α-helix	1129-1143	15
α-helix	1152-1165	14
α-helix	1170-1184	15
α-helix	1185-1191	7
α-helix	1192-1202	11
α-helix	1207-1218	12
α-helix	1263-1269	7
α-helix	1277-1294	18
α-helix	1298-1301	4
α-helix	1304-1309	6
α-helix	1311-1316	6
α-helix	1318-1328	11
α-helix	1332-1346	15
α-helix	1351-1366	16
α-helix	1380-1389	10
α-helix	1393-1406	14
α-helix	1410-1422	13
α-helix	1426-1439	14
α-helix	1447-1452	6
α-helix	1456-1469	14
α-helix	1474-1487	14
α-helix	1490-1499	10
α-helix	1506-1523	18
α-helix	1526-1535	10
α-helix	1541-1553	13
α-helix	1557-1578	22
α-helix	1587-1607	21
α-helix	1609-1611	3
α-helix	1612-1625	14
α-helix	1630-1640	11
α-helix	1646-1648	3
α-helix	1650-1662	13
α-helix	1666-1677	12
α-helix	1688-1690	3
α-helix	1694-1706	13
α-helix	1710-1731	22
α-helix	1738-1761	24
α-helix	1768-1782	15
α-helix	1787-1808	22
α-helix	1809-1813	5
α-helix	1869-1890	22
α-helix	1900-1913	14
α-helix	1917-1929	13
α-helix	1934-1938	5
α-helix	1939-1944	6
α-helix	1951-1966	16
α-helix	1973-1980	8
α-helix	1985-1999	15
α-helix	2004-2020	17
α-helix	2023-2035	13
α-helix	2036-2041	6
α-helix	2044-2058	15
α-helix	2065-2073	9
α-helix	2075-2089	15
α-helix	2094-2114	21
α-helix	2115-2117	3
β-strand	2120-2122	3	6
α-helix	2123-2126	4
α-helix	2128-2132	5
β-strand	2134	1	7
β-strand	2139	1	8
β-strand	2152	1	8
β-strand	2153-2156	4	7
β-strand	2159-2161	3	6
β-strand	2170	1	9
β-strand	2173-2176	4	7
β-strand	2181-2183	3	7
β-strand	2184-2187	4	9
α-helix	2193-2211	19
α-helix	2213-2218	6
β-strand	2227-2229	3	9
β-strand	2235-2238	4	9
α-helix	2239-2240	2
β-strand	2243-2245	3	10
α-helix	2246-2256	11
α-helix	2263-2271	9
α-helix	2275-2277	3
α-helix	2280-2292	13
α-helix	2298-2305	8
α-helix	2311-2334	24
β-strand	2344-2347	4	10
β-strand	2353-2355	3	10
α-helix	2364-2367	4
α-helix	2381-2385	5
α-helix	2395-2409	15
α-helix	2411-2422	12
α-helix	2429-2432	4
α-helix	2493-2509	17
α-helix	2521-2533	13
α-helix	2535-2539	5
α-helix	2543-2545	3

Chain C: 12 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	6-14	9	22
α-helix	20-28	9
α-helix	39-43	5
β-strand	45-52	8	22
β-strand	56-63	8	22
α-helix	67-74	8
α-helix	78-82	5
β-strand	85-93	9	22
α-helix	99-116	18
β-strand	121-127	7	22
α-helix	129-131	3
α-helix	134-136	3
α-helix	137-151	15
β-strand	158-161	4	22
α-helix	168-178	11
α-helix	184-198	15
β-strand	202-207	6	23
β-strand	213-218	6	23
α-helix	227-245	19
β-strand	249-255	7	23
β-strand	260-265	6	23
β-strand	270-276	7	23
α-helix	283-297	15

Chain D: 10 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	61-62	2
β-strand	63-67	5	24
α-helix	74-82	9
β-strand	111-114	4	24
α-helix	132-134	3
β-strand	139-145	7	24
α-helix	151-167	17
β-strand	172-178	7	24
α-helix	187-205	19
β-strand	213-217	5	24
α-helix	225-236	12
α-helix	243-253	11
β-strand	258-263	6	23
β-strand	269-272	4	23
α-helix	279-298	20
β-strand	315-320	6	23
β-strand	324-330	7	23
β-strand	335-342	8	23
α-helix	343-346	4
α-helix	349-367	19

Chain E: 1 helix, 35 β-strands

Element	Residues	Length	Sheet
β-strand	14-19	6	11
β-strand	23	1	12
β-strand	24-27	4	11
β-strand	36	1	11
β-strand	39	1	12
β-strand	47-50	4	13
β-strand	56	1	14
β-strand	57-60	4	13
β-strand	65-66	2	13
β-strand	69	1	14
β-strand	81	1	13
β-strand	88-91	4	15
β-strand	99-104	6	15
β-strand	108-113	6	15
β-strand	124-126	3	15
β-strand	133-137	5	16
β-strand	142-146	5	16
β-strand	152	1	17
β-strand	153-156	4	16
β-strand	165	1	17
β-strand	173-178	6	18
β-strand	184-189	6	18
β-strand	194-199	6	18
α-helix	200	1
β-strand	210-216	7	18
β-strand	223-228	6	19
β-strand	234-239	6	19
β-strand	243-248	6	19
β-strand	254-259	6	19
β-strand	273	1	20
β-strand	277-278	2	21
β-strand	284-288	5	21
β-strand	289	1	20
β-strand	294-298	5	21
β-strand	304-308	5	21
β-strand	315-321	7	11

Chain H: 2 helices, 35 β-strands

Element	Residues	Length	Sheet
β-strand	14-19	6	40
β-strand	23	1	41
β-strand	24-27	4	40
β-strand	36	1	40
β-strand	39	1	41
β-strand	47-50	4	42
β-strand	56	1	43
β-strand	57-60	4	42
β-strand	65-66	2	42
β-strand	69	1	43
β-strand	81	1	42
β-strand	88-91	4	44
β-strand	99-104	6	44
β-strand	108-113	6	44
β-strand	124-126	3	44
α-helix	130-131	2
β-strand	133-137	5	45
β-strand	142-146	5	45
β-strand	152	1	46
β-strand	153-156	4	45
β-strand	165	1	46
β-strand	173-178	6	47
β-strand	184-189	6	47
β-strand	194-199	6	47
α-helix	200	1
β-strand	210-216	7	47
β-strand	223-228	6	48
β-strand	234-239	6	48
β-strand	243-248	6	48
β-strand	254-259	6	48
β-strand	273	1	49
β-strand	277-278	2	50
β-strand	284-288	5	50
β-strand	289	1	49
β-strand	294-298	5	50
β-strand	304-308	5	50
β-strand	315-321	7	40

Chain I: 13 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	6-14	9	51
α-helix	20-28	9
α-helix	33-36	4
α-helix	39-42	4
β-strand	45-52	8	51
β-strand	56-63	8	51
α-helix	67-74	8
α-helix	78-82	5
β-strand	85-93	9	51
α-helix	99-116	18
β-strand	121-127	7	51
α-helix	129-131	3
α-helix	134-136	3
α-helix	137-151	15
β-strand	158-161	4	51
α-helix	168-178	11
α-helix	184-198	15
β-strand	202-207	6	52
β-strand	213-218	6	52
α-helix	227-245	19
β-strand	249-255	7	52
β-strand	260-265	6	52
β-strand	270-276	7	52
α-helix	283-297	15

Chain J: 10 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	61-62	2
β-strand	63-67	5	53
α-helix	74-80	7
β-strand	111-114	4	53
α-helix	132-134	3
β-strand	139-145	7	53
α-helix	151-167	17
β-strand	172-178	7	53
α-helix	187-205	19
β-strand	213-217	5	53
α-helix	225-236	12
α-helix	243-253	11
β-strand	258-263	6	52
β-strand	269-272	4	52
α-helix	279-298	20
β-strand	315-320	6	52
β-strand	324-330	7	52
β-strand	335-342	8	52
α-helix	343-346	4
α-helix	349-367	19

3 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
mTOR,Serine/threonine-protein kinase mTOR,mTOR,Serine/threonine-protein kinase mTOR	A, B	protein	2549	Homo sapiens	P42345 (AlphaFold model)
Target of rapamycin complex subunit LST8	E, H	protein	326	Homo sapiens	Q9BVC4 (AlphaFold model)
Ras-related GTP-binding protein A	C, I	protein	313	Homo sapiens	Q7L523 (AlphaFold model)
Ras-related GTP-binding protein C	D, J	protein	399	Homo sapiens	Q9HB90 (AlphaFold model)
Regulatory-associated protein of mTOR	N, Y	protein	1335	Homo sapiens	Q8N122
Proline-rich AKT1 substrate 1	O, T	protein	256	Homo sapiens	Q96B36

Sequence of entity 1 (A, B), FASTA

>6SB0_1 mTOR,Serine/threonine-protein kinase mTOR,mTOR,Serine/threonine-protein kinase mTOR (chains A, B)
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXS
TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP
VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP
TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
KDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTXXXXX
XXXXXXXXXXXXXXXXXXXXRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA
TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLT
QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLL
VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA
LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
VFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVD
RLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV
STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF
GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK
WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA
QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW
ERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVD
PSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHK
QELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEA
VLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSP
TPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVN
EALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVAS
KSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFG
ERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQA
WDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSL
QVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNL
SIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTL
MQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRH
PSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITC
HTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDG
VELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLD
VPTQVELLIKQATSHENLCQCYIGWCPFW

Sequence of entity 2 (E, H), FASTA

>6SB0_2 Target of rapamycin complex subunit LST8 (chains E, H)
MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA
GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ
CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP
DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA
DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE
TGEIKREYGGHQKAVVCLAFNDSVLG

Sequence of entity 3 (C, I), FASTA

>6SB0_3 Ras-related GTP-binding protein A (chains C, I)
MPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNL
WDCGGLDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDA
KIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECACFRTSIWDETLYKAWSSIVYQL
IPNVQQLEMNLRNFAQIIEADEVLLFERATFLVISHYQCKEQRDVHRFEKISNIIKQFKL
SCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKL
ERVDGPKHSLLMR

Sequence of entity 4 (D, J), FASTA

>6SB0_4 Ras-related GTP-binding protein C (chains D, J)
MSLQYGAEETPLAGSYGAADSFPKDFGYGVEEEEEEAAAAGGGVGAGAGGGCGPGGADSS
KPRILLMGLRRSGKSSIQKVVFHKMSPNENLFLESTNKIYKDDISNSSFVNFQIWDFPGQ
MDFFDPTFDYEMIFRGTGALIYVIDAQDDYMEALTRLHITVSKAYKVNPDMNFEVFIHKV
DGLSDDHKIETQRDIHQRANDDLADAGLEKLHLSFYLTSIYDHSIFEAFSKVVQKLIPQL
PTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSPVDMQSYELCCDMIDVVIDVSCIYG
LKEDGSGSAYDKESMAIIKLNNTTVLYLKEVTKFLALVCILREESFERKGLIDYNFHCFR
KAIHEVFEVGVTSHRSCGHQTSASSLKALTHNGTPRNAI

Sequence of entity 5 (N, Y), FASTA

>6SB0_5 Regulatory-associated protein of mTOR (chains N, Y)
MESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSV
ALVLCLNVGVDPPDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRARYK
QSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNGEVWVFNKNYTQYIPLSIY
DLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELEVAAINPNHPLAQMPLPPSMKNC
IQLAACEATELLPMIPDLPADLFTSCLTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPG
RLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLLVASLFRNFLLAERIMRSY
NCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWL
TMGVENRNPPEQLPIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLALSVGIFPYVLKLL
QSSARELRPLLVFIWAKILAVDSSCQADLVKDNGHKYFLSVLADPYMPAEHRTMTAFILA
VIVNSYHTGQEACLQGNLIAICLEQLNDPHPLLRQWVAICLGRIWQNFDSARWCGVRDSA
HEKLYSLLSDPIPEVRCAAVFALGTFVGNSAERTDHSTTIDHNVAMMLAQLVSDGSPMVR
KELVVALSHLVVQYESNFCTVALQFIEEEKNYALPSPATTEGGSLTPVRDSPCTPRLRSV
SSYGNIRAVATARSLNKSLQNLSLTEESGGAVAFSPGNLSTSSSASSTLGSPENEEHILS
FETIDKMRRASSYSSLNSLIGVSFNSVYTQIWRVLLHLAADPYPEVSDVAMKVLNSIAYK
ATVNARPQRVLDTSSLTQSAPASPTNKGVHIHQAGGSPPASSTSSSSLTNDVAKQPVSRD
LPSGRPGTTGPAGAQYTPHSHQFPRTRKMFDKGPEQTADDADDAAGHKSFISATVQTGFC
DWSARYFAQPVMKIPEEHDLESQIRKEREWRFLRNSRVRRQAQQVIQKGITRLDDQIFLN
RNPGVPSVVKFHPFTPCIAVADKDSICFWDWEKGEKLDYFHNGNPRYTRVTAMEYLNGQD
CSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLLMS
SGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRMALS
ECRVMTYREHTAWVVKASLQKRPDGHIVSVSVNGDVRIFDPRMPESVNVLQIVKGLTALD
IHPQADLIACGSVNQFTAIYNSSGELINNIKYYDGFMGQRVGAISCLAFHPHWPHLAVGS
NDYYISVYSVEKRVR

Sequence of entity 6 (O, T), FASTA

>6SB0_6 Proline-rich AKT1 substrate 1 (chains O, T)
MASGRPEELWEAVVGAAERFRARTGTELVLLTAAPPPPPRPGPCAYAAHGRGALAEAARR
CLHDIALAHRAATAARPPAPPPAPQPPSPTPSPPRPTLAREDNEEDEDEPTETETSGEQL
GISDNGGLFVMDEDATLQDLPPFCESDPESTDDGSLSEETPAGPPTCSVPPASALPTQQY
AKSLPVSVPVWGFKEKRTEARSSDEENGPPSSPDLDRIAASMRALVLREAEDTQVFGDLP
RPRLNTSDFQKLKRKY

Ligands and cofactors

ID	Name	Formula	Copies
GTP	Guanosine-5'-triphosphate	C10 H16 N5 O14 P3	2
GDP	Guanosine-5'-diphosphate	C10 H15 N5 O11 P2	2

Primary citation

Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Anandapadamanaban, M., Masson, G.R., Perisic, O. et al. Science (2019) 366:203-210. DOI 10.1126/science.aax3939 · PubMed

Other PDB entries of the same protein (UniProt P42345 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4DRI 1.45 Å, Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of…
9DBO 1.55 Å, Crystal structure of a synthetic Fab (R3E9) in complex with the FRB domain of mTOR
5GPG 1.67 Å, Co-crystal structure of the FK506 binding domain of human FKBP25, Rapamycin and the FRB…
5WBH 1.75 Å, Structure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1
4DRJ 1.8 Å, o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR
3FAP 1.85 Å, Atomic structures of the rapamycin analogs in complex with both human FKBP12 and frb…
8PPZ 1.85 Å, Co-crystal structure of FKBP12, compound 7 and the FRB fragment of mTOR
8XI9 1.85 Å, Crystal structure of FRB-FKBP fusion protein in complex with rapamycin
9PIW 1.9 Å, Crystal structure of a synthetic Fab (1A) in complex with the FRB domain of mTOR
9DL0 2.0 Å, Crystal structure of a synthetic Fab (R3H8) in complex with the FRB domain of mTOR
9PJ1 2.05 Å, Crystal structure of a synthetic Fab (4R) in complex with the ternary assembly of…
9PIU 2.18 Å, Crystal structure of a synthetic Fab (2C) in complex with the FRB domain of mTOR

Browse structure collections

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