6UYU: K45-acetylated SUMO1

Crystal structure of K45-acetylated SUMO1 in complex with phosphorylated PML-SIM. Determined by X-ray diffraction at 1.66 Å resolution. Released 27 Nov 2019.

Method: X-ray diffraction
Resolution: 1.66 Å
Organism: Homo sapiens
Chains: 4
Atoms: 1,681
Mol. weight: 25.73 kDa
Released: 27 Nov 2019

Explore 6UYU in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6UYU contains 12 α-helices and 12 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	21-27	7	1
β-strand	33-39	7	1
α-helix	45-55	11
α-helix	59-61	3
β-strand	62-66	5	1
β-strand	69-70	2	1
α-helix	71-72	2
α-helix	77-80	4
β-strand	87-92	6	1

Chain B: 2 helices, 1 β-strand

Element	Residues	Length	Sheet
α-helix	7-9	3
β-strand	11-13	3	1
α-helix	14-15	2

Chain C: 5 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	21-27	7	2
α-helix	28	1
β-strand	33-39	7	2
α-helix	45-55	11
α-helix	59-61	3
β-strand	62-66	5	2
β-strand	69-70	2	2
α-helix	71-72	2
α-helix	77-80	4
β-strand	87-92	6	2

Chain D: 1 helix, 1 β-strand

Element	Residues	Length	Sheet
β-strand	11-13	3	2
α-helix	14-15	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Small ubiquitin-related modifier 1	A, C	protein	83	Homo sapiens	P63165 (AlphaFold model)
Protein PML	B, D	protein	29	Homo sapiens	P29590 (AlphaFold model)

Sequence of entity 1 (A, C), FASTA

>6UYU_1 Small ubiquitin-related modifier 1 (chains A, C)
GSKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYAQRQGVPMNSLRFLFEGQRIADN
HTPKELGMEEEDVIEVYQEQTGG

Sequence of entity 2 (B, D), FASTA

>6UYU_2 Protein PML (chains B, D)
GSGAGEAEERVVVISSSEDSDAENSSSRY

Primary citation

Acetylation of SUMO1 Alters Interactions with the SIMs of PML and Daxx in a Protein-Specific Manner. Mascle, X.H., Gagnon, C., Wahba, H.M. et al. Structure (2020) 28:157-168.e5. DOI 10.1016/j.str.2019.11.019 · PubMed

Other PDB entries of the same protein (UniProt P63165 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6UYR 1.3 Å, Crystal structure of K46-acetylated SUMO1 in complex with PML-SIM
4WJQ 1.35 Å, Crystal Structure of SUMO1 in complex with Daxx
6V7Q 1.35 Å, Crystal structure of SUMO1 in complex with phosphorylated PIAS-SIM2
6V7P 1.4 Å, Crystal structure of SUMO1 in complex with PIAS-SIM2
2UYZ 1.4 Å, Non-covalent complex between Ubc9 and SUMO1
6UYZ 1.4 Å, Crystal structure of K46-acetylated SUMO1 in complex with phosphorylated DAXX
6UYV 1.4 Å, Crystal structure of K46-acetylated SUMO1 in complex with phosphorylated PML-SIM
6UYP 1.42 Å, Crystal structure of K39-acetylated SUMO1 in complex with PML-SIM
4WJO 1.46 Å, Crystal Structure of SUMO1 in complex with PML
6V7S 1.47 Å, Crystal structure of K37-acetylated SUMO1 in complex with phosphorylated PIAS-SIM2
4WJN 1.5 Å, Crystal structure of SUMO1 in complex with phosphorylated PML
6UYQ 1.5 Å, Crystal structure of K45-acetylated SUMO1 in complex with PML-SIM

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