6UZ0: Cardiac sodium channel with flecainide

Cardiac sodium channel with flecainide. Determined by electron microscopy at 3.24 Å resolution. Released 1 Jan 2020.

Method
Electron microscopy
Resolution
3.24 Å
Organisms
Rattus norvegicus, Aequorea victoria
Chains
1
Atoms
9,557
Mol. weight
221.95 kDa
Ligands
K4D, 6OU, 9Z9, NAG
Released
1 Jan 2020

Explore 6UZ0 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6UZ0 contains 62 α-helices and 8 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 62 helices, 8 β-strands

ElementResiduesLengthSheet
α-helix120-13011
α-helix132-14918
α-helix158-18023
α-helix183-1919
α-helix193-21018
α-helix218-22912
α-helix230-2334
α-helix237-25014
α-helix252-27322
α-helix276-2783
β-strand280-28341
α-helix304-3096
α-helix3161
β-strand31712
α-helix3181
β-strand32412
α-helix334-3374
β-strand340-34341
α-helix359-37113
α-helix375-38511
α-helix388-3903
α-helix391-3966
α-helix397-4026
α-helix403-42927
α-helix701-71414
α-helix721-73616
α-helix744-76926
α-helix774-7796
α-helix781-79717
α-helix807-82216
α-helix824-83613
α-helix841-86828
α-helix870-8723
α-helix888-89912
α-helix903-91210
α-helix915-94329
α-helix1191-120414
α-helix1207-122519
α-helix1229-12313
α-helix1235-126935
α-helix1272-129221
α-helix1305-131410
α-helix1315-13184
α-helix1320-133011
α-helix1333-135725
β-strand136713
β-strand138214
α-helix1383-13897
β-strand139513
α-helix1408-141912
α-helix1423-14308
β-strand143814
α-helix1439-14413
α-helix1446-14483
α-helix1449-14568
α-helix1457-14615
α-helix1463-148220
α-helix1491-150212
α-helix1518-152811
α-helix1530-154819
α-helix1556-158126
α-helix1587-15904
α-helix1592-161120
α-helix1623-16297
α-helix1632-16354
α-helix1636-16394
α-helix1644-168037
α-helix1699-171012
α-helix1715-17239
α-helix1747-177933

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Sodium channel protein type 5 subunit alpha,Green fluorescent proteinAprotein1838Rattus norvegicus, Aequorea victoriaP15389 (AlphaFold model), P42212 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>6UZ0_1 Sodium channel protein type 5 subunit alpha,Green fluorescent protein (chains A)
MANLLLPRGTSSFRRFTRESLAAIEKRMAEKQARGGSATSQESREGLQEEEAPRPQLDLQ
ASKKLPDLYGNPPRELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHP
VRRAAVKILVHSLFSMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILAR
GFCLHAFTFLRDPWNWLDFSVIVMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTI
VGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTELNGTNGSVEADGL
VWNSLDVYLNDPANYLLKNGTTDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFA
WAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQ
NQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSARQRALSAVSVLTSALEEL
EESHRKCPPCWNRFAQHYLIWECCPLWMSIKQKVKFVVMDPFADLTITMCIVLNTLFMAL
EHYNMTAEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMEL
GLSRMGNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVV
GMQLFGKNYSELRHRISDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSL
CLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDGEMNNLQLALARIQRGLRFVK
RTTWDFCCGILRRRPKKPAALATHSQLPSCITAPRSPPPPEVEKVPPARKETRFEEDKRP
GQGTPGDSEPVCVPIAVAESDTEDQEEDEENGKVWWRLRKTCYRIVEHSWFETFIIFMIL
LSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDF
LIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMN
VLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSECESFNVTGELYWT
KVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEDNLYMYIYFVVFIIF
GSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK
YQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKVNILAKINLLFVAIFTGECI
VKMAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRL
IRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQT
FANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGILFFTTYI
IISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYLALSD
FADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQME
EKFMAANPSKISYEPITTTLEVLFQGPGSMVSKGEELFTGVVPILVELDGDVNGHKFSVS
GEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLTYGVQCFSRYPDHMKQHDFFKSAMPE
GYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNV
YIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKD
PNEKRDHMVLLEFVTAAGITLGMDELYKGSDYKDDDDK

Ligands and cofactors

IDNameFormulaCopies
K4DFlecainideC17 H20 F6 N2 O31
6OU[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-y…C39 H76 N O8 P11
9Z9(3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-enC34 H56 O55
NAG2-acetamido-2-deoxy-beta-D-glucopyranoseC8 H15 N O62

Primary citation

Structure of the Cardiac Sodium Channel. Jiang, D., Shi, H., Tonggu, L. et al. Cell (2020) 180:122-134.e10. DOI 10.1016/j.cell.2019.11.041 · PubMed

Other PDB entries of the same protein (UniProt P15389 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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