Cardiac sodium channel. Determined by electron microscopy at 3.5 Å resolution. Released 1 Jan 2020.
Explore 6UZ3 in 3D Show helices and sheets RCSB PDB PDBe
6UZ3 contains 67 α-helices and 10 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 122-129 | 8 | |
| α-helix | 132-150 | 19 | |
| α-helix | 156-180 | 25 | |
| α-helix | 183-190 | 8 | |
| α-helix | 193-210 | 18 | |
| α-helix | 222-228 | 7 | |
| α-helix | 229-233 | 5 | |
| α-helix | 237-250 | 14 | |
| α-helix | 252-272 | 21 | |
| α-helix | 276-278 | 3 | |
| β-strand | 280-282 | 3 | 1 |
| α-helix | 305-310 | 6 | |
| α-helix | 312-314 | 3 | |
| β-strand | 317 | 1 | 2 |
| β-strand | 324 | 1 | 2 |
| α-helix | 334-336 | 3 | |
| β-strand | 341-343 | 3 | 1 |
| α-helix | 359-371 | 13 | |
| α-helix | 375-385 | 11 | |
| α-helix | 388-390 | 3 | |
| α-helix | 391-398 | 8 | |
| α-helix | 399-405 | 7 | |
| α-helix | 406-423 | 18 | |
| α-helix | 701-715 | 15 | |
| α-helix | 721-736 | 16 | |
| α-helix | 744-771 | 28 | |
| α-helix | 774-779 | 6 | |
| α-helix | 781-797 | 17 | |
| α-helix | 807-809 | 3 | |
| α-helix | 816-818 | 3 | |
| α-helix | 819-822 | 4 | |
| α-helix | 824-835 | 12 | |
| α-helix | 841-857 | 17 | |
| α-helix | 859-863 | 5 | |
| α-helix | 864-866 | 3 | |
| α-helix | 870-873 | 4 | |
| α-helix | 888-898 | 11 | |
| α-helix | 903-912 | 10 | |
| α-helix | 915-943 | 29 | |
| α-helix | 1191-1204 | 14 | |
| α-helix | 1207-1225 | 19 | |
| α-helix | 1231-1233 | 3 | |
| α-helix | 1235-1263 | 29 | |
| α-helix | 1265-1270 | 6 | |
| α-helix | 1272-1292 | 21 | |
| α-helix | 1306-1314 | 9 | |
| α-helix | 1315-1318 | 4 | |
| α-helix | 1322-1330 | 9 | |
| α-helix | 1333-1358 | 26 | |
| β-strand | 1366-1367 | 2 | 3 |
| β-strand | 1382 | 1 | 4 |
| α-helix | 1387-1389 | 3 | |
| β-strand | 1395-1396 | 2 | 3 |
| α-helix | 1408-1418 | 11 | |
| α-helix | 1424-1431 | 8 | |
| β-strand | 1438 | 1 | 4 |
| α-helix | 1446-1448 | 3 | |
| α-helix | 1449-1456 | 8 | |
| α-helix | 1457-1462 | 6 | |
| α-helix | 1463-1481 | 19 | |
| α-helix | 1491-1502 | 12 | |
| α-helix | 1518-1527 | 10 | |
| α-helix | 1530-1548 | 19 | |
| α-helix | 1556-1581 | 26 | |
| α-helix | 1587-1590 | 4 | |
| α-helix | 1592-1616 | 25 | |
| α-helix | 1623-1627 | 5 | |
| α-helix | 1630-1637 | 8 | |
| α-helix | 1638-1641 | 4 | |
| α-helix | 1644-1654 | 11 | |
| α-helix | 1656-1680 | 25 | |
| α-helix | 1684-1686 | 3 | |
| β-strand | 1687 | 1 | 5 |
| β-strand | 1690 | 1 | 5 |
| α-helix | 1699-1710 | 12 | |
| α-helix | 1715-1723 | 9 | |
| α-helix | 1747-1779 | 33 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Sodium channel protein type 5 subunit alpha,Green fluorescent protein | A | protein | 1838 | Rattus norvegicus, Aequorea victoria | P15389 (AlphaFold model), P42212 (AlphaFold model) |
>6UZ3_1 Sodium channel protein type 5 subunit alpha,Green fluorescent protein (chains A) MANLLLPRGTSSFRRFTRESLAAIEKRMAEKQARGGSATSQESREGLQEEEAPRPQLDLQ ASKKLPDLYGNPPRELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHP VRRAAVKILVHSLFSMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILAR GFCLHAFTFLRDPWNWLDFSVIVMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTI VGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTELNGTNGSVEADGL VWNSLDVYLNDPANYLLKNGTTDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFA WAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQ NQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSARQRALSAVSVLTSALEEL EESHRKCPPCWNRFAQHYLIWECCPLWMSIKQKVKFVVMDPFADLTITMCIVLNTLFMAL EHYNMTAEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMEL GLSRMGNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVV GMQLFGKNYSELRHRISDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSL CLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDGEMNNLQLALARIQRGLRFVK RTTWDFCCGILRRRPKKPAALATHSQLPSCITAPRSPPPPEVEKVPPARKETRFEEDKRP GQGTPGDSEPVCVPIAVAESDTEDQEEDEENGKVWWRLRKTCYRIVEHSWFETFIIFMIL LSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDF LIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMN VLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSECESFNVTGELYWT KVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEDNLYMYIYFVVFIIF GSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK YQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKVNILAKINLLFVAIFTGECI VKMAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRL IRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQT FANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGILFFTTYI IISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYLALSD FADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQME EKFMAANPSKISYEPITTTLEVLFQGPGSMVSKGEELFTGVVPILVELDGDVNGHKFSVS GEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLTYGVQCFSRYPDHMKQHDFFKSAMPE GYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNV YIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKD PNEKRDHMVLLEFVTAAGITLGMDELYKGSDYKDDDDK
| ID | Name | Formula | Copies |
|---|---|---|---|
| 6OU | [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-y… | C39 H76 N O8 P | 11 |
| 9Z9 | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en | C34 H56 O5 | 5 |
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 2 |
Structure of the Cardiac Sodium Channel. Jiang, D., Shi, H., Tonggu, L. et al. Cell (2020) 180:122-134.e10. DOI 10.1016/j.cell.2019.11.041 · PubMed
Other PDB entries of the same protein (UniProt P15389 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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