6WLX: PAK4 kinase domain

PAK4 kinase domain in complex with beta-catenin Ser675 substrate peptide. Determined by X-ray diffraction at 2.2 Å resolution. Released 24 Jun 2020.

Method: X-ray diffraction
Resolution: 2.2 Å
Organism: Homo sapiens
Chains: 2
Atoms: 2,407
Mol. weight: 39.99 kDa
Released: 24 Jun 2020

Explore 6WLX in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6WLX contains 22 α-helices and 13 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 22 helices, 13 β-strands

Element	Residues	Length	Sheet
α-helix	301-311	11
α-helix	313	1
α-helix	317-319	3
β-strand	321-329	9	1
β-strand	334-340	7	1
β-strand	346-353	8	1
α-helix	354-356	3
α-helix	360-362	3
α-helix	363-372	10
β-strand	378	1	2
β-strand	381-387	7	1
β-strand	390-395	6	1
β-strand	402	1	2
α-helix	403-407	5
α-helix	414-433	20
β-strand	436-437	2	3
α-helix	443-445	3
β-strand	446-448	3	2
β-strand	454-456	3	2
β-strand	463-464	2	3
β-strand	472	1	4
α-helix	479-481	3
α-helix	484-487	4
β-strand	492	1	4
α-helix	495-510	16
α-helix	520-529	10
α-helix	531-535	5
α-helix	538-540	3
α-helix	543-552	10
α-helix	561-562	2
α-helix	563-566	4
α-helix	570-574	5
α-helix	575-577	3
α-helix	578-580	3
α-helix	582-584	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Serine/threonine-protein kinase PAK 4	A	protein	346	Homo sapiens	O96013 (AlphaFold model)
Catenin beta-1	B	protein	7	Homo sapiens	P35222 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>6WLX_1 Serine/threonine-protein kinase PAK 4 (chains A)
MGSSHHHHHHSSGLVPRGSHMENLYFQGARARQENGMPEKPPGPRSPQREPQRVSHEQFR
AALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN
EVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVL
QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE
LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSL
KGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR

Sequence of entity 2 (B), FASTA

>6WLX_2 Catenin beta-1 (chains B)
KKRLSVE

Primary citation

Recognition of physiological phosphorylation sites by p21-activated kinase 4. Chetty, A.K., Sexton, J.A., Ha, B.H. et al. J Struct Biol (2020) 211:107553-107553. DOI 10.1016/j.jsb.2020.107553 · PubMed

Other PDB entries of the same protein (UniProt O96013 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2J0I 1.6 Å, Crystal structure of the human P21-activated kinase 4
2Q0N 1.75 Å, Structure of human p21 activating kinase 4 (PAK4) in complex with a consensus peptide
5VEF 1.75 Å, PAK4 kinase domain in complex with fasudil
5ZJW 1.8 Å, Crystal Structure of PAK4 in complex with inhibitor CZg353
5XVA 1.85 Å, Crystal Structure of PAK4 in complex with inhibitor CZH216
4JDI 1.85 Å, Crystal structure of Serine/threonine-protein kinase PAK 4 in complex with Paktide S…
8AHG 1.89 Å, PAC-FragmentDEL: Photoactivated covalent capture of DNA encoded fragments for hit…
6WLY 1.9 Å, PAK4 kinase domain in complex with LIMK1 Thr508 substrate peptide
7S48 1.9 Å, PAK4cat in complex with Integrin beta5 760-770 peptide
4FIH 1.97 Å, Catalytic domain of human PAK4 with QKFTGLPRQW peptide
4FII 2.0 Å, Catalytic domain of human PAK4 with RPKPLVDP peptide
4JDH 2.0 Å, Crystal structure of Serine/threonine-protein kinase PAK 4 in complex with Paktide T…

Browse structure collections

About this viewer

MolViewer shows 6WLX directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.