6XA1: 60S ribosomal protein L8
Structure of a drug-like compound stalled human translation termination complex. Determined by electron microscopy at 2.8 Å resolution. Released 7 Oct 2020.
- Method
- Electron microscopy
- Resolution
- 2.8 Å
- Organism
- Homo sapiens
- Chains
- 83
- Atoms
- 211,887
- Mol. weight
- 3134.5 kDa
- Ligands
- MG, MVM, ZN
- Released
- 7 Oct 2020
Explore 6XA1 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
6XA1 contains 559 α-helices and 578 β-strands across 77 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain j: 20 helices, 21 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 12-24 | 13 | |
| β-strand | 34-39 | 6 | 29 |
| α-helix | 45-58 | 14 | |
| α-helix | 65-77 | 13 | |
| α-helix | 82-84 | 3 | |
| α-helix | 88-89 | 2 | |
| β-strand | 93-97 | 5 | 29 |
| β-strand | 99-101 | 3 | 30 |
| β-strand | 107-109 | 3 | 30 |
| β-strand | 112-114 | 3 | 29 |
| α-helix | 115-116 | 2 | |
| β-strand | 124-128 | 5 | 29 |
| α-helix | 136-139 | 4 | |
| β-strand | 147-152 | 6 | 31 |
| β-strand | 155-161 | 7 | 31 |
| β-strand | 166-172 | 7 | 31 |
| α-helix | 176-179 | 4 | |
| α-helix | 184-186 | 3 | |
| α-helix | 187-213 | 27 | |
| β-strand | 214 | 1 | 32 |
| β-strand | 219 | 1 | 32 |
| β-strand | 224-228 | 5 | 31 |
| α-helix | 233-237 | 5 | |
| α-helix | 244-247 | 4 | |
| β-strand | 250-255 | 6 | 31 |
| α-helix | 264-270 | 7 | |
| α-helix | 273-277 | 5 | |
| α-helix | 279-282 | 4 | |
| α-helix | 284-290 | 7 | |
| α-helix | 292-295 | 4 | |
| β-strand | 301 | 1 | 33 |
| α-helix | 306-310 | 5 | |
| β-strand | 317-319 | 3 | 33 |
| β-strand | 320-323 | 4 | 34 |
| β-strand | 329 | 1 | 35 |
| β-strand | 346 | 1 | 35 |
| α-helix | 374-380 | 7 | |
| β-strand | 389-392 | 4 | 34 |
| α-helix | 399-404 | 6 | |
| β-strand | 409 | 1 | 34 |
| β-strand | 412-413 | 2 | 33 |
Chain La: 7 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-5 | 3 | |
| α-helix | 7-10 | 4 | |
| α-helix | 42-48 | 7 | |
| α-helix | 65-68 | 4 | |
| β-strand | 72-74 | 3 | 26 |
| α-helix | 79-81 | 3 | |
| α-helix | 84-92 | 9 | |
| β-strand | 97-98 | 2 | 104 |
| α-helix | 99 | 1 | |
| β-strand | 100-102 | 3 | 27 |
| β-strand | 110-112 | 3 | 26 |
| β-strand | 123-126 | 4 | 27 |
| β-strand | 128-129 | 2 | 26 |
| β-strand | 143-146 | 4 | 27 |
Chain LA: 10 helices, 18 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-9 | 4 | |
| α-helix | 29-32 | 4 | |
| α-helix | 34-38 | 5 | |
| β-strand | 40-49 | 10 | 1 |
| α-helix | 50-51 | 2 | |
| β-strand | 58-64 | 7 | 1 |
| α-helix | 65 | 1 | |
| β-strand | 71-77 | 7 | 1 |
| β-strand | 79 | 1 | 2 |
| β-strand | 83 | 1 | 3 |
| β-strand | 87-91 | 5 | 1 |
| β-strand | 101-103 | 3 | 4 |
| α-helix | 104-106 | 3 | |
| β-strand | 112-113 | 2 | 5 |
| β-strand | 116 | 1 | 6 |
| β-strand | 126 | 1 | 6 |
| β-strand | 134-140 | 7 | 5 |
| β-strand | 145-149 | 5 | 5 |
| β-strand | 155-159 | 5 | 5 |
| β-strand | 163-165 | 3 | 4 |
| β-strand | 166 | 1 | 5 |
| β-strand | 169 | 1 | 2 |
| α-helix | 174-176 | 3 | |
| α-helix | 182-190 | 9 | |
| α-helix | 201-203 | 3 | |
| β-strand | 224-225 | 2 | 7 |
| α-helix | 229-230 | 2 | |
| β-strand | 237-238 | 2 | 7 |
Chain Lb: 6 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 12-15 | 4 | |
| α-helix | 22-24 | 3 | |
| α-helix | 37-48 | 12 | |
| α-helix | 54-65 | 12 | |
| α-helix | 92-99 | 8 | |
| α-helix | 106-116 | 11 | |
Chain LB: 18 helices, 20 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 9-10 | 2 | |
| α-helix | 14-16 | 3 | |
| α-helix | 20-22 | 3 | |
| α-helix | 32-35 | 4 | |
| β-strand | 42-43 | 2 | 17 |
| β-strand | 45-59 | 15 | 18 |
| β-strand | 71-80 | 10 | 18 |
| α-helix | 82-83 | 2 | |
| β-strand | 84-95 | 12 | 19 |
| β-strand | 98-106 | 9 | 19 |
| α-helix | 112-115 | 4 | |
| α-helix | 116-118 | 3 | |
| α-helix | 131-134 | 4 | |
| α-helix | 135-137 | 3 | |
| α-helix | 143-156 | 14 | |
| β-strand | 159-165 | 7 | 19 |
| α-helix | 168-170 | 3 | |
| β-strand | 180-184 | 5 | 19 |
| β-strand | 185-186 | 2 | 17 |
| α-helix | 190-199 | 10 | |
| β-strand | 204-205 | 2 | 19 |
| α-helix | 207-209 | 3 | |
| β-strand | 216-222 | 7 | 18 |
| β-strand | 227-229 | 3 | 20 |
| α-helix | 231-235 | 5 | |
| α-helix | 237-240 | 4 | |
| β-strand | 270-272 | 3 | 20 |
| β-strand | 276-288 | 13 | 18 |
| β-strand | 292-295 | 4 | 21 |
| β-strand | 297-299 | 3 | 21 |
| α-helix | 316 | 1 | |
| β-strand | 320 | 1 | 22 |
| β-strand | 324 | 1 | 22 |
| β-strand | 330-334 | 5 | 18 |
| β-strand | 344-349 | 6 | 18 |
| α-helix | 361-363 | 3 | |
| β-strand | 365-368 | 4 | 18 |
| α-helix | 382-389 | 8 | |
Chain Lc: 4 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 10-21 | 12 | |
| β-strand | 26-29 | 4 | 39 |
| α-helix | 31-38 | 8 | |
| β-strand | 45-48 | 4 | 39 |
| α-helix | 54-67 | 14 | |
| β-strand | 70-73 | 4 | 39 |
| α-helix | 78-84 | 7 | |
| β-strand | 93-98 | 6 | 39 |
Chain LC: 28 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7-11 | 5 | 41 |
| α-helix | 12 | 1 | |
| β-strand | 17-23 | 7 | 41 |
| α-helix | 24-25 | 2 | |
| α-helix | 26-29 | 4 | |
| α-helix | 34-44 | 11 | |
| α-helix | 45-48 | 4 | |
| α-helix | 49-51 | 3 | |
| β-strand | 64-66 | 3 | 42 |
| β-strand | 77-79 | 3 | 42 |
| β-strand | 90 | 1 | 42 |
| α-helix | 100-101 | 2 | |
| α-helix | 104-106 | 3 | |
| α-helix | 117-129 | 13 | |
| α-helix | 130-132 | 3 | |
| α-helix | 134-139 | 6 | |
| β-strand | 152-154 | 3 | 41 |
| α-helix | 158-160 | 3 | |
| α-helix | 164-173 | 10 | |
| α-helix | 178-185 | 8 | |
| β-strand | 188-189 | 2 | 43 |
| α-helix | 190-191 | 2 | |
| α-helix | 193-196 | 4 | |
| β-strand | 201-202 | 2 | 43 |
| β-strand | 208-211 | 4 | 41 |
| α-helix | 217-220 | 4 | |
| β-strand | 228-231 | 4 | 41 |
| α-helix | 237-240 | 4 | |
| α-helix | 242-244 | 3 | |
| β-strand | 250-253 | 4 | 41 |
| α-helix | 254-257 | 4 | |
| α-helix | 260-263 | 4 | |
| α-helix | 279-282 | 4 | |
| α-helix | 289-293 | 5 | |
| α-helix | 296-299 | 4 | |
| α-helix | 302-305 | 4 | |
| α-helix | 312-314 | 3 | |
| α-helix | 322-328 | 7 | |
| α-helix | 332-353 | 22 | |
Chain Ld: 3 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 22-28 | 7 | 44 |
| α-helix | 38-40 | 3 | |
| α-helix | 41-56 | 16 | |
| β-strand | 62-63 | 2 | 44 |
| α-helix | 66-72 | 7 | |
| β-strand | 83-92 | 10 | 44 |
| β-strand | 102-109 | 8 | 44 |
| β-strand | 120-122 | 3 | 44 |
69 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| 60S ribosomal protein L8 | LA | protein | 248 | Homo sapiens | P62917 (AlphaFold model) |
| 60S ribosomal protein L3 | LB | protein | 396 | Homo sapiens | P39023 (AlphaFold model) |
| 28S rRNA | L5 | RNA | 3510 | Homo sapiens | |
| 5S rRNA | L7 | RNA | 120 | Homo sapiens | |
| 5.8S rRNA | L8 | RNA | 155 | Homo sapiens | |
| 60S ribosomal protein L4 | LC | protein | 358 | Homo sapiens | P36578 (AlphaFold model) |
| 60S ribosomal protein L5 | LD | protein | 290 | Homo sapiens | P46777 (AlphaFold model) |
| 60S ribosomal protein L6 | LE | protein | 247 | Homo sapiens | Q02878 |
| 60S ribosomal protein L7 | LF | protein | 225 | Homo sapiens | P18124 |
| 60S ribosomal protein L7a | LG | protein | 241 | Homo sapiens | P62424 |
| 60S ribosomal protein L9 | LH | protein | 190 | Homo sapiens | P32969 |
| 60S ribosomal protein L10-like | LI | protein | 213 | Homo sapiens | Q96L21 |
71 more molecules are not listed.
Sequence of entity 1 (LA), FASTA
>6XA1_1 60S ribosomal protein L8 (chains LA)
GRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKV
VFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKPG
DRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPILK
AGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAAR
RTGRLRGT
Sequence of entity 2 (LB), FASTA
>6XA1_2 60S ribosomal protein L3 (chains LB)
SHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREVD
RPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYKN
WHKSKKKAFTKYCKKWQDEDGKKQLEKDFSSMKKYCQVIRVIAHTQMRLLPLRQKKAHLM
EIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKLP
RKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIKN
NASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSLLVQTKRRALE
KIDLKFIDTTSKFGHGRFQTMEEKKAFMGPLKKDRI
Sequence of entity 3 (L5), FASTA
>6XA1_3 28S rRNA (chains L5)
CGCGACCUCAGAUCAGACGUGGCGACCCGCUGAAUUUAAGCAUAUUAGUCAGCGGAGGAG
AAGAAACUAACCAGGAUUCCCUCAGUAACGGCGAGUGAACAGGGAAGAGCCCAGCGCCGA
AUCCCCGCCCCGGGGGCGCGGGACAUGUGGCGUACGGAAGACCCGCUCCCCGGGGGGCCC
AAGUCCUUCUGAUCGAGGCCCCGUGGACGGUGUGAGGCCGGUAGCGGCCCCCGGGCCCGG
GUCUUCCCGGAGUCGGGUUGCUUGGGAAUGCAGCCCAAAGCGGGUGGUAAACUCCAUCUA
AGGCUAAAUACCGGCACGAGACCGAUAGUCAACAAGUACCGUAAGGGAAAGUUGAAAAGA
ACUUUGAAGAGAGAGUUCAAGAGGGCGUGAAACCGUUAAGAGGUAAACGGGUGGGGUCCG
CGCAGUCCGCCCGGAGGAUUCAACCCGGCGGCGGGUCCGGCCGGGCGGAUCUGGGACCGU
CCCCGGCCGCCGCCGGGCGCAUUUCCACCGCGGCGGUGCGCCGCGACCGGCUCCGGGACG
GCUGGGAAGGCCCGGCGGGGAAGGUGGCUCGGCCGAGUGUUACAGCCCCCCCGGCAGCAG
CACUCGCCGAAUCCCGGGGCCGAGGGAGCGAGACCCGUCGCCGCGCUCUCCCCCCUGGGG
GGGCCGGGCCACCCCUCCCACGGCGCGACCGCUGGGGCGGACUGUUCCCAGUGCGCCCCG
GGCGGGUCGCGCCGUCGGGCCCGGGGGGCCACGCGCGCGUCCCGGGACGGCGGAGCGAGC
GCACGGGGUCGGCGGCGACGUCGGCUACCCACCCGACCCGUCUUGAAACACGGACCAAGG
AGUCUAACACGUGCGCGAGUCGGGGGCUCGCACGAAAGCCGCCGUGGCGCAAUGAAGGUG
AAGGCCGGCCGAGGUGGGAUCCCGAGGCCUCUCCAGUCCGCCGAGGGCGCACCACCGGCC
CGUCUCGCCCGCCGCGCCGGGGAGGUGGAGCACGAGCGCACGUGUUAGGACCCGAAAGAU
GGUGAACUAUGCCUGGGCAGGGCGAAGCCAGAGGAAACUCUGGUGGAGGUCCGUAGCGGU
CCUGACGUGCAAAUCGGUCGUCCGACCUGGGUAUAGGGGCGAAAGACUAAUCGAACCAUC
UAGUAGCUGGUUCCCUCCGAAGUUUCCCUCAGGAUAGCUGGCGCUCUCGCAGACCCGACG
CCCGCCACGCAGUUUUAUCCGGUAAAGCGAAUGAUUAGAGGUCUUGGUCAACCUAUUCUC
AAACUUUAAAUGGGUAAGAAGCCCGGCUCGCUGGCGUGGAGCCGGGCGUGGAAUGCGAGU
GCCUAGUGGGCCACUUUUGGUAAGCAGAACUGGCGCUGCGGGAUGAACCGAACGCCGGGU
UAAGGCGCCCGAUGCCGACGCUCAUCAGACCCCAGAAAAGGUGUUGGUUGAUAUAGACAG
CAGGACGGUGGCCAUGGAAGUCGGAAUCCGCUAAGGAGUGUGUAACAACUCACCUGCCGA
AUCAACUAGCCCUGAAAAUGGAUGGCGCUGGAGCGUCGGGCCCAUACCCGGCCGUCGCCG
GCAGUCGAGAGUGGACGGGAGCGGCGGGCCGGAGCCCCGCGGACGCUACGCCGCGACGAG
UAGGAGGGCCGCUGCGGUGAGCCUUGAAGCCUAGGGCGCGGGCCCGGGUGGAGCCGCCGC
AGGUGCAGAUCUUGGUGGUAGUAGCAAAUAUUCAAACGAGAACUUUGAAGGCCGAAGUGG
AGAAGGGUUCCAUGUGAACAGCAGUUGAACAUGGGUCAGUCGGUCCUGAGAGAUGGGCGA
GCGCCGUUCCGAAGGGACGGGCGAUGGCCUCCGUUGCCCUCGGCCGAUCGAAAGGGAGUC
GGGUUCAGAUCCCCGAAUCCGGAGUGGCGGAGAUGGGCGCCGCGAGGCGUCCAGUGCGGU
AACGCGACCGAUCCCGGAGAAGCCGGCGGGAGCCCCGGGGAGAGUUCUCUUUUCUUUGUG
AAGGGCAGGGCGCCCUGGAAUGGGUUCGCCCCGAGAGAGGGGCCCGUGCCUUGGAAAGCG
UCGCGGUUCCGGCGGCGUCCGGUGAGCUCUCGCUGGCCCUUGAAAAUCCGGGGGAGAGGG
UGUAAAUCUCGCGCCGGGCCGUACCCAUAUCCGCAGCAGGUCUCCAAGGUGAACAGCCUC
UGGCAUGUUGGAACAAUGUAGGUAAGGGAAGUCGGCAAGCCGGAUCCGUAACUUCGGGAU
AAGGAUUGGCUCUAAGGGCUGGGUCGGUCGCGGCCGGCGCCUAGCAGCCGACUUAGAACU
GGUGCGGACCAGGGGAAUCCGACUGUUUAAUUAAAACAAAGCAUCGCGAAGGCCCGCGGC
GGGUGUUGACGCGAUGUGAUUUCUGCCCAGUGCUCUGAAUGUCAAAGUGAAGAAAUUCAA
UGAAGCGCGGGUAAACGGCGGGAGUAACUAUGACUCUCUUAAGGUAGCCAAAUGCCUCGU
CAUCUAAUUAGUGACGCGCAUGAAXGGAUGAACGAGAUUCCCACUGUCCCUACCUACUAU
CCAGCGAAACCACAGCCAAGGGAACGGGCUUGGCGGAAUCAGCGGGGAAAGAAGACCCUG
UUGAGCUUGACUCUAGUCUGGCACGGUGAAGAGACUUUUUUCACUGACCCGGUGAGGCGG
GGGGGCGAGCUCUCGCUUCUGGCGCCAAGCGCCCGGCGCCGGGCGCGACCCGCUCCGGGG
ACAGUGCCAGGUGGGGAGUUUGACUGGGGCGGUACACCUGUCAAACGGUAACGCAGGUGU
CCUAAGGCGAGCUCAGGGAGGACAGAAACCUCCCGUGGAGCAGAAGGGCAAAAGCUCGCU
UGAUCUUGAUUUUCAGUACGAAUACAGACCGUGAAAGCGGGGCCUCACGAUCCUUCUGAC
CUUUUGGGUUUUAAGCAGGAGGUGUCAGAAAAGUUACCACAGGGAUAACUGGCUUGUGGC
GGCCAAGCGUUCAUAGCGACGUCGCUUUUUGAUCCUUCGAUGUCGGCUCUUCCUAUCAUU
GUGAAGCAGAAUUCACCAAGCGUUGGAUUGUUCACCCACUAAUAGGGAACGUGAGCUGGG
UUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUGAUGAUGUGUUGUUGCCAUGGUA
AUCCUGCUCAGUACGAGAGGAACCGCAGGUUCAGACAUUUGGUGUAUGUGCUUGGCUGAG
GAGCCAAUGGGGCGAAGCUACCAUCUGUGGGAUUAUGACUGAACGCCUCUAAGUCAGAAU
CCCGCCCAGGCGGAACGAUACAGCGCCGCGGAGCCUCGGUUGGCCUCGGAUAGCCGGUCC
CGGGUCCGGUGCGGAGUGCCCUUCGUCCUGGGAAACGGGGCGCGGCCGGAGAGGCGGCCG
CCCCCUCGCCCGUCACGCACCGCACGUUCGUGGGGAACCUGGCGCUAAACCAUUCGUAGA
CGACCUGCUUCUGGGUCGGGGUUUCGUACGUAGCAGAGCAGCUCCCUCGCUGCGAUCUAU
UGAAAGUCAGCCCUCGACACAAGGGUUUGU
Sequence of entity 4 (L7), FASTA
>6XA1_4 5S rRNA (chains L7)
GUCUACGGCCAUACCACCCUGAACGCGCCCGAUCUCGUCUGAUCUCGGAAGCUAAGCAGG
GUCGGGCCUGGUUAGUACUUGGAUGGGAGACCGCCUGGGAAUACCGGGUGCUGUAGGCUU
Sequence of entity 5 (L8), FASTA
>6XA1_5 5.8S rRNA (chains L8)
GACUCUUAGCGGUGGAUCACUCGGCUCGUGCGUCGAUGAAGAACGCAGCUAGCUGCGAGA
AUUAAUGUGAAUUGCAGGACACAUUGAUCAUCGACACUUCGAACGCACUUGCGGCCCCGG
GUUCCUCCCGGGGCUACGCCUGUCUGAGCGUCGCU
Sequence of entity 6 (LC), FASTA
>6XA1_6 60S ribosomal protein L4 (chains LC)
MACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGH
QTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQK
RYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAWNDI
KKVYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKL
APGGHVGRFCIWTESAFRKLDELYGTWRKAASLKSNYNLPMHKMINTDLSRILKSPEIQR
ALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVDKAAAAA
Sequence of entity 7 (LD), FASTA
>6XA1_7 60S ribosomal protein L5 (chains LD)
GFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDII
CQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEG
QVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFP
GYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMYK
KAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQ
Sequence of entity 8 (LE), FASTA
>6XA1_8 60S ribosomal protein L6 (chains LE)
PHCSRNPVLVRGIGRYSRSAMYSRKAMYKRKYSAAKSKVEKKKKEKVLATVTKPVGGDKN
GGTRVVKLRKMPRYYPTEDVPRKLLSHGKKPFSQHVRKLRASITPGTILIILTGRHRGKR
VVFLKQLASGLLLVTGPLVLNRVPLRRTHQKFVIATSTKIDISNVKIPKHLTDAYFKKKK
LRKPRHQEGEIFDTEKEKYEITEQRKIDQKAVDSQILPKIKAIPQLQGYLRSVFALTNGI
YPHKLVF
Sequence of entity 9 (LF), FASTA
>6XA1_9 60S ribosomal protein L7 (chains LF)
NFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYV
PAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWG
YPNLKSVNELIYKRGYGKINKKRIALTDNALIARSLGKYGIICMEDLIHEIYTVGKRFKE
ANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQINRLIRRMN
Sequence of entity 10 (LG), FASTA
>6XA1_10 60S ribosomal protein L7a (chains LG)
KVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLKVPPAINQFTQ
ALDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAGKGDVPTKRPPVLRAGVNTVTT
LVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVPYCIIKGKARLGRLVHRKTCTTVAFT
QVNSEDKGALAKLVEAIRTNYNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKL
G
Sequence of entity 11 (LH), FASTA
>6XA1_11 60S ribosomal protein L9 (chains LH)
MKTILSNQTVDIPENVDITLKGRTVIVKGPRGTLRRDFNHINVELSLLGKKKKRLRVDKW
WGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQENGSLVEIRNFLGE
KYIRRVRMRPGVACSVSQAQKDELILEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIY
VSEKGTVQQA
Sequence of entity 12 (LI), FASTA
>6XA1_12 60S ribosomal protein L10-like (chains LI)
GRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLGGHMVSDEYEQLS
SEALEAARICANKYMVKSCGRDGFHMRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGK
PQGTVARVHIGQVIMSIRTKLQNEEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADEF
EDMVAKKCLIPDGCGVKYVPSHGPLDKWRVLHS
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| MG | Magnesium ion | Mg | 190 |
| MVM | N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]py… | C22 H20 Cl N7 O | 1 |
| ZN | Zinc ion | Zn | 8 |
Water and common crystallization additives (K) are not listed.
Primary citation
Selective inhibition of human translation termination by a drug-like compound. Li, W., Chang, S.T., Ward, F.R. et al. Nat Commun (2020) 11:4941-4941. DOI 10.1038/s41467-020-18765-2 · PubMed
Other PDB entries of the same protein (UniProt P62917 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 8A3D 1.67 Å, Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound
- 29IW 1.77 Å, Human monosomes with bound toxin NT-2, focus on 60S subunit. Cells treated with NT-2.
- 8QYX 1.78 Å, Human 60S ribosomal subunit
- 8QOI 1.9 Å, Structure of the human 80S ribosome at 1.9 A resolution - the molecular role of chemical…
- 9O3W 1.9 Å, Human 80S ribosome bound to IDB-001 stalled on MYC nascent chain
- 8YOO 2.0 Å, Cryo-EM structure of the human 80S ribosome with 100 um Tigecycline
- 9C3H 2.0 Å, Structure of the CNOT3-bound human 80S ribosome with tRNA-ARG in the P-site.
- 29IZ 2.08 Å, Dormant 80S:eEF2:SERBP1:tRNA complex from human cells treated with toxin NT-2
- 9TV2 2.1 Å, 80S ribosomes from primary B-cells infected with delta v-snoRNA1 EBV
- 9I2D 2.19 Å, NMT1-NAC bound human RNC with 10 amino acid ARF1-linker
- 9PBE 2.19 Å, In situ human 80S ribosome (composite map)
- 29IX 2.2 Å, Human monosomes with bound toxin NT-2, focus on 60S subunit. NT-2 added to purified…
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