Structure of Human Dispatched-1 (DISP1). Determined by electron microscopy at 4.53 Å resolution. Released 8 Jul 2020.
Explore 6XE6 in 3D Show helices and sheets RCSB PDB PDBe
6XE6 contains 27 α-helices and 8 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 180-187 | 8 | |
| α-helix | 189-209 | 21 | |
| α-helix | 230-242 | 13 | |
| β-strand | 302 | 1 | 1 |
| α-helix | 321-326 | 6 | |
| α-helix | 355-358 | 4 | |
| α-helix | 371-384 | 14 | |
| α-helix | 424-431 | 8 | |
| α-helix | 459-460 | 2 | |
| α-helix | 463-471 | 9 | |
| β-strand | 488 | 1 | 1 |
| α-helix | 492-522 | 31 | |
| α-helix | 525-548 | 24 | |
| α-helix | 558-569 | 12 | |
| α-helix | 572-587 | 16 | |
| α-helix | 593-622 | 30 | |
| α-helix | 628-660 | 33 | |
| α-helix | 689-715 | 27 | |
| α-helix | 720-735 | 16 | |
| β-strand | 755 | 1 | 2 |
| α-helix | 760-768 | 9 | |
| β-strand | 784 | 1 | 3 |
| β-strand | 794 | 1 | 4 |
| β-strand | 811 | 1 | 4 |
| α-helix | 824-836 | 13 | |
| α-helix | 853-861 | 9 | |
| α-helix | 885-895 | 11 | |
| β-strand | 932 | 1 | 3 |
| α-helix | 939-954 | 16 | |
| α-helix | 972-1002 | 31 | |
| α-helix | 1007-1029 | 23 | |
| α-helix | 1038-1061 | 24 | |
| α-helix | 1070-1095 | 26 | |
| β-strand | 1102 | 1 | 2 |
| α-helix | 1103-1133 | 31 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Protein dispatched homolog 1 | A | protein | 1096 | Homo sapiens | Q96F81 (AlphaFold model) |
>6XE6_1 Protein dispatched homolog 1 (chains A) MAWSHPQFEKSRPFKLPKSYAALIADWPVVVLGMCTMFIVVCALVGVLVPELPDFSDPLL GFEPRGTAIGQRLVTWNNMVKNTGYKATLANYPFKYADEQAKSHRDDRWSDDHYEREKRE VDWNFHKDSFFCDVPSDRYSRVVFTSSGGETLWNLPAIKSMCNVDNSRIRSHPQFGDLCQ RTTAASCCPSWTLGNYIAILNNRSSCQKIVERDVSHTLKLLRTCAKHYQNGTLGPDCWDM AARRKDQLKCTNVPRKCTKYNAVYQILHYLVDKDFMTPKTADYATPALKYSMLFSPTEKG ESMMNIYLDNFENWNSSDGVTTITGIEFGIKHSLFQDYLLMDTVYPAIAIVIVLLVMCVY TKSMFITLMTMFAIISSLIVSYFLYRVVFHFEFFPFMNLTALIILVGIGADDAFVLCDVW NYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAI LVNYVLMVTWLPAVVVLHERYLLNIFTCFKKPQQQIYDNKSCWTVACQKCHKVLFAISEA SRIFFEKVLPCIVIKFRYLWLFWFLALTVGGAYIVCINPKMKLPSLELSEFQVFRSSHPF ERYDAEYKKLFMFERVHHGEELHMPITVIWGVSPEDNGNPLNPKSKGKLTLDSSFNIASP ASQAWILHFCQKLRNQTFFYQTDEQDFTSCFIETFKQWMENQDCDEPALYPCCSHWSFPY KQEIFELCIKRAIMELERSTGYHLDSKTPGPRFDINDTIRAVVLEFQSTYLFTLAYEKMH QFYKEVDSWISSELSSAPEGLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLL TTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYR LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWA FATFFFQCMCRCLGPQGTCGQIPLPKKLQCSAFSHALSTSPSDKGQSKTHTINAYHLDPR GPKSELEHEFYELEPLASHSCTAPEKTTYEETHICSEFFNSQAKNLGMPVHAAYNSELSK STESDAGSDYKDDDDK
| ID | Name | Formula | Copies |
|---|---|---|---|
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 1 |
| Y01 | Cholesterol hemisuccinate | C31 H50 O4 | 5 |
Structure of human Dispatched-1 provides insights into Hedgehog ligand biogenesis. Chen, H., Liu, Y., Li, X. Life Sci Alliance (2020) 3. DOI 10.26508/lsa.202000776 · PubMed
Other PDB entries of the same protein (UniProt Q96F81 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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