6XFM: RNA-binding protein FUS

Molecular structure of the core of amyloid-like fibrils formed by residues 111-214 of FUS. Determined by electron microscopy at 2.62 Å resolution. Released 7 Oct 2020.

Method: Electron microscopy
Resolution: 2.62 Å
Organism: Homo sapiens
Chains: 8
Atoms: 2,360
Mol. weight: 80.2 kDa
Released: 7 Oct 2020

Explore 6XFM in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6XFM contains 0 α-helices and 32 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains 1, 2, 3, 4, 5, 6, 7 and 8: 0 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	3-13	11	1
β-strand	22	1	2
β-strand	25-26	2	3
β-strand	29-39	11	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
RNA-binding protein FUS	1, 2, 3, 4, 5, 6, 7, 8	protein	104	Homo sapiens	P35637 (AlphaFold model)

Sequence of entity 1 (1, 2, 3, 4, 5, 6, 7, 8), FASTA

>6XFM_1 RNA-binding protein FUS (chains 1, 2, 3, 4, 5, 6, 7, 8)
GSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGG
GGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQGDRG

Primary citation

Molecular structure and interactions within amyloid-like fibrils formed by a low-complexity protein sequence from FUS. Lee, M., Ghosh, U., Thurber, K.R. et al. Nat Commun (2020) 11:5735-5735. DOI 10.1038/s41467-020-19512-3 · PubMed

Other PDB entries of the same protein (UniProt P35637 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6KJ3 0.6 Å, 120kV MicroED structure of FUS (37-42) SYSGYS solved from merged datasets at 0.60 A
6KJ1 0.65 Å, 200kV MicroED structure of FUS (37-42) SYSGYS solved from merged datasets at 0.65 A
6KJ4 0.65 Å, 120kV MicroED structure of FUS (37-42) SYSGYS solved from single crystal at 0.65 A
6KJ2 0.67 Å, 200kV MicroED structure of FUS (37-42) SYSGYS solved from single crystal at 0.67 A
5XSG 0.73 Å, Ultrahigh resolution structure of FUS (37-42) SYSGYS determined by MicroED
6BWZ 1.1 Å, SYSGYS from low-complexity domain of FUS, residues 37-42
6BXV 1.1 Å, SYSSYGQS from low-complexity domain of FUS, residues 54-61
6BZP 1.1 Å, STGGYG from low-complexity domain of FUS, residues 77-82
5XRR 1.5 Å, Crystal structure of FUS (54-59) SYSSYG
4FDD 2.3 Å, Crystal structure of KAP beta2-PY-NLS
7CYL 2.7 Å, Crystal structure of Karyopherin-beta2 in complex with FUS PY-NLS(P525L)
5YVI 2.9 Å, Crystal structure of Karyopherin beta2 in complex with FUS(456-526)

Browse structure collections

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