7CYL: Karyopherin-beta2

Crystal structure of Karyopherin-beta2 in complex with FUS PY-NLS(P525L). Determined by X-ray diffraction at 2.7 Å resolution. Released 24 Feb 2021.

Method
X-ray diffraction
Resolution
2.7 Å
Organism
Homo sapiens
Chains
2
Atoms
6,827
Mol. weight
104.11 kDa
Released
24 Feb 2021

Explore 7CYL in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7CYL contains 68 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 66 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix9-2214
α-helix27-4014
α-helix44-5512
α-helix62-7918
α-helix80-823
α-helix85-9814
α-helix104-11613
α-helix117-1215
α-helix123-1253
α-helix129-1379
α-helix142-15817
α-helix160-1634
α-helix172-1798
α-helix180-1823
α-helix188-19912
α-helix207-2104
α-helix213-22311
α-helix229-24517
α-helix247-2504
α-helix251-2533
α-helix254-26512
α-helix270-28314
α-helix289-2935
α-helix297-30711
α-helix310-3112
α-helix312-3187
α-helix375-39016
α-helix391-3944
α-helix395-40511
α-helix411-42313
α-helix429-4324
α-helix433-4353
α-helix436-44611
α-helix452-46312
α-helix466-4716
α-helix478-48912
α-helix494-51118
α-helix512-5154
α-helix519-53214
α-helix535-55218
α-helix553-5564
α-helix559-57517
α-helix583-59715
α-helix598-6047
α-helix605-62824
α-helix634-6363
α-helix639-65517
α-helix656-6594
α-helix660-6645
α-helix668-6758
α-helix681-69717
α-helix699-7013
α-helix703-7053
α-helix706-71510
α-helix722-73918
α-helix740-7467
α-helix748-75811
α-helix765-78117
α-helix783-7864
α-helix787-7893
α-helix790-80213
α-helix808-82316
α-helix826-8294
α-helix832-8409
α-helix847-87327
α-helix878-88710
Chain B: 2 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix514-5207
α-helix523-5242

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Transportin-1Aprotein868Homo sapiensQ92973 (AlphaFold model)
RNA-binding protein FUSBprotein54Homo sapiensP35637 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>7CYL_1 Transportin-1 (chains A)
GSMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLK
SEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIA
SKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPK
FLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRA
LVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLP
KLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRGGSGGSGDTISDWNLRKCSAAA
LDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPH
LIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACS
AFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYI
QMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQ
AMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLVARSNILTLMYQCMQDKMPE
VRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFISVCNNATWAIGEISIQMGIE
MQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLR
NIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWINPKDDLRDMFCKILHGFKN
QVGDENWRRFSDQFPLPLKERLAAFYGV
Sequence of entity 2 (B), FASTA
>7CYL_2 RNA-binding protein FUS (chains B)
GGSRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKMDSRGEHRQDRRERLY

Primary citation

Mechanism of karyopherin-beta 2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X). Gonzalez, A., Mannen, T., Cagatay, T. et al. Sci Rep (2021) 11:3754-3754. DOI 10.1038/s41598-021-83196-y · PubMed

Other PDB entries of the same protein (UniProt Q92973 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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