Cdc7-Dbf4 bound to ADP-BeF3. Determined by X-ray diffraction at 1.79 Å resolution. Released 27 May 2020.
Explore 6YA8 in 3D Show helices and sheets RCSB PDB PDBe
6YA8 contains 28 α-helices and 19 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 39-50 | 12 | |
| α-helix | 52-56 | 5 | |
| β-strand | 59-66 | 8 | 1 |
| β-strand | 70-78 | 9 | 1 |
| β-strand | 79 | 1 | 2 |
| β-strand | 84-92 | 9 | 1 |
| α-helix | 98-106 | 9 | |
| α-helix | 107-111 | 5 | |
| β-strand | 117 | 1 | 3 |
| β-strand | 122-126 | 5 | 1 |
| β-strand | 129-135 | 7 | 1 |
| α-helix | 142-148 | 7 | |
| α-helix | 151-170 | 20 | |
| β-strand | 173-174 | 2 | 4 |
| α-helix | 180-182 | 3 | |
| β-strand | 183-186 | 4 | 3 |
| β-strand | 191-194 | 4 | 3 |
| β-strand | 201-202 | 2 | 4 |
| α-helix | 209-213 | 5 | |
| β-strand | 358-359 | 2 | 5 |
| α-helix | 361-364 | 4 | |
| α-helix | 367-369 | 3 | |
| α-helix | 377-379 | 3 | |
| α-helix | 382-385 | 4 | |
| α-helix | 394-409 | 16 | |
| α-helix | 420-431 | 12 | |
| α-helix | 433-442 | 10 | |
| β-strand | 445-449 | 5 | 6 |
| α-helix | 454-457 | 4 | |
| α-helix | 458-466 | 9 | |
| α-helix | 540-549 | 10 | |
| α-helix | 558-559 | 2 | |
| α-helix | 560-564 | 5 | |
| α-helix | 567-569 | 3 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 213-214 | 2 | 5 |
| α-helix | 215-216 | 2 | |
| β-strand | 219-224 | 6 | 6 |
| α-helix | 230-231 | 2 | |
| β-strand | 232-235 | 4 | 6 |
| α-helix | 247 | 1 | |
| β-strand | 294-296 | 3 | 7 |
| β-strand | 301-303 | 3 | 7 |
| α-helix | 306-310 | 5 | |
| α-helix | 313-319 | 7 | |
| α-helix | 325-331 | 7 | |
| β-strand | 338 | 1 | 2 |
| α-helix | 341-344 | 4 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Cell division cycle 7-related protein kinase,Cell division cycle 7-related protein kinase,Cell… | A | protein | 359 | Homo sapiens | O00311 (AlphaFold model) |
| Protein DBF4 homolog A | B | protein | 144 | Homo sapiens | Q9UBU7 (AlphaFold model) |
>6YA8_1 Cell division cycle 7-related protein kinase,Cell division cycle 7-related protein kinase,Cell division cycle 7-related protein kinase (chains A) MLAGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPT SHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVR EYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQ SEAQQERCSQNKPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTT AIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEV PAQDLRKLCERLRGAGAGGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
>6YA8_2 Protein DBF4 homolog A (chains B) GPGTRTGRLKKPFVKVEDMSQLYRPFYLQLTNMPFINYSIQKPCSPFDVDKPSSMQKQTQ VKLRIQTDGDKYGGTSIQLQLKEKKKKGYCECCLQKYEDLETHLLSEQHRNFAQSNQYQV VDDIVSKLVFDFVEYEKDTPKKKR
| ID | Name | Formula | Copies |
|---|---|---|---|
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 1 |
| MG | Magnesium ion | Mg | 2 |
| BEF | Beryllium trifluoride ion | Be F3 | 1 |
| ZN | Zinc ion | Zn | 2 |
Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase. Dick, S.D., Federico, S., Hughes, S.M. et al. Structure (2020) 28:954-962.e4. DOI 10.1016/j.str.2020.05.010 · PubMed
Other PDB entries of the same protein (UniProt O00311 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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