6YIE: Borealin-INCENP-Survivin complex
Structure of a Borealin-INCENP-Survivin complex. Determined by X-ray diffraction at 3.49 Å resolution. Released 13 May 2020.
- Method
- X-ray diffraction
- Resolution
- 3.49 Å
- Organism
- Homo sapiens
- Chains
- 6
- Atoms
- 3,583
- Mol. weight
- 70.54 kDa
- Ligands
- ZN
- Released
- 13 May 2020
Explore 6YIE in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
6YIE contains 23 α-helices and 10 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 6 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 11-13 | 3 | |
| α-helix | 15-20 | 6 | |
| α-helix | 35-40 | 6 | |
| β-strand | 43-45 | 3 | 1 |
| β-strand | 55-57 | 3 | 1 |
| β-strand | 63-64 | 2 | 1 |
| α-helix | 73-80 | 8 | |
| α-helix | 93-95 | 3 | |
| β-strand | 97 | 1 | 2 |
| α-helix | 98-138 | 41 | |
Chain B: 3 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| α-helix | 16-60 | 45 | |
| α-helix | 63-66 | 4 | |
| β-strand | 69 | 1 | 2 |
| α-helix | 70-75 | 6 | |
Chain C: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 10-26 | 17 | |
| α-helix | 27-31 | 5 | |
| α-helix | 32-45 | 14 | |
Chain D: 5 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 11-13 | 3 | |
| α-helix | 15-21 | 7 | |
| α-helix | 35-41 | 7 | |
| β-strand | 43-45 | 3 | 3 |
| β-strand | 55-57 | 3 | 3 |
| β-strand | 63-64 | 2 | 3 |
| α-helix | 73-80 | 8 | |
| β-strand | 97 | 1 | 4 |
| α-helix | 98-136 | 39 | |
Chain E: 3 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| α-helix | 18-60 | 43 | |
| α-helix | 63-66 | 4 | |
| β-strand | 69 | 1 | 4 |
| α-helix | 70-75 | 6 | |
Chain F: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 10-25 | 16 | |
| α-helix | 26-30 | 5 | |
| α-helix | 31-44 | 14 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Baculoviral IAP repeat-containing protein 5 | A, D | protein | 144 | Homo sapiens | O15392 (AlphaFold model) |
| Borealin | B, E | protein | 100 | Homo sapiens | Q53HL2 (AlphaFold model) |
| Inner centromere protein | C, F | protein | 60 | Homo sapiens | Q9NQS7 (AlphaFold model) |
Sequence of entity 1 (A, D), FASTA
>6YIE_1 Baculoviral IAP repeat-containing protein 5 (chains A, D)
GPMGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCF
FCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETN
NKKKEFEETAKKVRRAIEQLAAMD
Sequence of entity 2 (B, E), FASTA
>6YIE_2 Borealin (chains B, E)
VAKTNSLRRRKLASFLKDFDREVEIRIKQIESDRQNLLKEVDNLYNIEILRLPKALREMN
WLDYFALGGNKQALEEAATADLDITEINKLTAEAIQTPLK
Sequence of entity 3 (C, F), FASTA
>6YIE_3 Inner centromere protein (chains C, F)
GPMGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPK
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 2 |
Primary citation
Molecular basis of MKLP2-dependent Aurora B transport from chromatin to the anaphase central spindle. Serena, M., Bastos, R.N., Elliott, P.R. et al. J Cell Biol (2020) 219. DOI 10.1083/jcb.201910059 · PubMed
Other PDB entries of the same protein (UniProt O15392 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 2QFA 1.4 Å, Crystal structure of a Survivin-Borealin-INCENP core complex
- 9TPI 1.8 Å, Survivin 1-122 in complex with a molecular tweezer-Histone-H3-peptide conjugate
- 6YIF 1.81 Å, Structure of Chromosomal Passenger Complex (CPC) bound to phosphorylated Histone 3…
- 9TPH 2.0 Å, Survivin 1-127 in complex with a molecular tweezer-Histone-H3-peptide conjugate
- 3UEC 2.18 Å, Crystal structure of human Survivin bound to histone H3 phosphorylated on threonine-3.
- 2RAW 2.4 Å, Crystal structure of the Borealin-Survivin complex
- 3UIG 2.4 Å, crystal structure of human Survivin in complex with T3 phosphorylated H3(1-15) peptide
- 3UIH 2.4 Å, crystal structure of human Survivin in complex with Smac/DIABLO(1-15) peptide
- 8RUP 2.42 Å, Chromosome Passenger Complex (CPC) localization module in complex with H3.T3p-nucleosome
- 3UEF 2.45 Å, Crystal structure of human Survivin bound to histone H3 (C2 space group).
- 7LBO 2.5 Å, Crystal structure of human Survivin bound to histone H3 T3phK4me1 peptide
- 6YIH 2.55 Å, Structure of Chromosomal Passenger Complex (CPC) bound to phosphorylated Histone 3…
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