6Z6M: Human 80S ribosomes

Name: PDB 6Z6M: Cryo-EM structure of human 80S ribosomes bound to EBP1, eEF2 and SERBP1
Published: 2020-07-29
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: ribosome

Cryo-EM structure of human 80S ribosomes bound to EBP1, eEF2 and SERBP1. Determined by electron microscopy at 3.1 Å resolution. Released 29 Jul 2020.

Method: Electron microscopy
Resolution: 3.1 Å
Organism: Homo sapiens
Chains: 84
Atoms: 228,884
Mol. weight: 4023.53 kDa
Ligands: ZN, MG
Released: 29 Jul 2020

Explore 6Z6M in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6Z6M contains 545 α-helices and 606 β-strands across 79 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain CA: 11 helices, 23 β-strands

Element	Residues	Length	Sheet
α-helix	15-38	24
β-strand	44	1	18
α-helix	45-62	18
β-strand	72-82	11	19
β-strand	85	1	20
α-helix	96-97	2
β-strand	99	1	18
β-strand	105-114	10	19
β-strand	117-126	10	19
α-helix	129-130	2
β-strand	135	1	21
α-helix	138-156	19
β-strand	159	1	22
β-strand	161	1	22
β-strand	162	1	23
α-helix	163-176	14
β-strand	180-181	2	19
β-strand	185-190	6	19
β-strand	200-203	4	19
α-helix	207-211	5
β-strand	217	1	23
β-strand	222-231	10	19
β-strand	238	1	20
β-strand	246-249	4	24
α-helix	260-272	13
β-strand	278	1	24
α-helix	280-282	3
α-helix	287-298	12
β-strand	302-305	4	24
β-strand	309	1	20
β-strand	316-326	11	19
β-strand	329-332	4	19
β-strand	343	1	21
α-helix	352-359	8

Chain CB: 41 helices, 44 β-strands

Element	Residues	Length	Sheet
α-helix	6-14	9
β-strand	19-25	7	33
α-helix	32-43	12
α-helix	63-66	4
β-strand	73-79	7	33
α-helix	83-88	6
β-strand	98-104	7	33
α-helix	105-106	2
α-helix	113-121	9
β-strand	124-130	7	33
α-helix	137-148	12
β-strand	152-158	7	33
α-helix	160-164	5
α-helix	171-191	21
β-strand	212-216	5	33
β-strand	221-223	3	33
α-helix	225-235	11
α-helix	248-260	13
β-strand	265-267	3	34
β-strand	272-274	3	34
β-strand	278	1	35
α-helix	283	1
β-strand	284	1	35
α-helix	285-286	2
β-strand	287	1	34
α-helix	288-289	2
α-helix	290-294	5
α-helix	295-306	12
α-helix	309-319	11
α-helix	326-328	3
α-helix	333-343	11
β-strand	345	1	33
α-helix	346-357	12
α-helix	361-368	8
β-strand	373	1	36
α-helix	380-387	8
β-strand	395-403	9	37
β-strand	410-418	9	37
β-strand	421-422	2	38
β-strand	426-427	2	39
β-strand	428-430	3	37
β-strand	442	1	37
β-strand	445-446	2	39
β-strand	450-454	5	37
β-strand	457-461	5	37
β-strand	463-464	2	38
β-strand	468-472	5	37
β-strand	483-486	4	37
β-strand	494	1	36
α-helix	495-497	3
β-strand	505-511	7	40
α-helix	517-530	14
β-strand	535-539	5	40
β-strand	543-548	6	40
α-helix	551-560	10
α-helix	561-565	5
β-strand	570-573	4	40
α-helix	574-577	4
β-strand	580-583	4	41
β-strand	591-594	4	42
β-strand	601-608	8	42
α-helix	609-610	2
α-helix	611-619	9
α-helix	628-639	12
α-helix	643-647	5
β-strand	651	1	42
α-helix	654-656	3
β-strand	660-664	5	42
α-helix	672-688	17
α-helix	695-696	2
β-strand	697	1	41
β-strand	700-708	9	42
α-helix	718-720	3
α-helix	722-735	14
β-strand	738-743	6	41
β-strand	744-751	8	43
α-helix	756-765	10
β-strand	769-774	6	43
β-strand	782-789	8	43
α-helix	796-804	9
β-strand	811-812	2	43
β-strand	817-819	3	41
α-helix	830-842	13
α-helix	848-850	3
α-helix	851-854	4

Chain CD: 4 helices, 0 β-strands

Element	Residues	Length
α-helix	206-208	3
α-helix	209-211	3
α-helix	219-220	2
α-helix	283-292	10

Chain La: 8 helices, 7 β-strands

Element	Residues	Length	Sheet
α-helix	3-5	3
α-helix	7-11	5
α-helix	42-48	7
α-helix	65-68	4
β-strand	72-73	2	15
α-helix	75-78	4
α-helix	84-92	9
β-strand	98	1	112
β-strand	100-102	3	16
α-helix	103-106	4
β-strand	110-111	2	15
β-strand	123-126	4	16
β-strand	128-129	2	15
α-helix	131-140	10
β-strand	143-146	4	16

Chain LA: 13 helices, 20 β-strands

Element	Residues	Length	Sheet
α-helix	4-5	2
α-helix	8-12	5
α-helix	14-16	3
β-strand	18	1	25
α-helix	30-32	3
α-helix	34-38	5
β-strand	40-49	10	26
α-helix	50-51	2
β-strand	58-64	7	26
β-strand	71-77	7	26
α-helix	78	1
β-strand	79	1	27
β-strand	83	1	28
β-strand	86-91	6	26
β-strand	101-103	3	26
β-strand	112-113	2	29
β-strand	116	1	30
β-strand	126	1	30
β-strand	134-140	7	29
α-helix	142-144	3
β-strand	145-150	6	29
β-strand	154-159	6	29
β-strand	163-165	3	26
β-strand	166	1	29
β-strand	169	1	27
α-helix	174-176	3
α-helix	182-192	11
β-strand	193	1	25
α-helix	198-200	3
α-helix	201-203	3
β-strand	224-225	2	31
α-helix	229-230	2
β-strand	237-238	2	31

Chain Lb: 6 helices, 0 β-strands

Element	Residues	Length
α-helix	12-19	8
α-helix	37-48	12
α-helix	49-51	3
α-helix	54-73	20
α-helix	92-100	9
α-helix	106-116	11

Chain LB: 15 helices, 20 β-strands

Element	Residues	Length	Sheet
α-helix	14-16	3
α-helix	32-35	4
α-helix	40-41	2
β-strand	42-43	2	44
β-strand	45-59	15	45
β-strand	71-80	10	45
α-helix	82-83	2
β-strand	84-95	12	46
β-strand	98-105	8	46
α-helix	112-118	7
α-helix	131-138	8
α-helix	141-156	16
β-strand	159-165	7	46
α-helix	168-170	3
β-strand	180-184	5	46
β-strand	185-186	2	44
α-helix	190-199	10
β-strand	203-205	3	46
α-helix	207-210	4
β-strand	216-222	7	45
α-helix	223-225	3
β-strand	227-229	3	47
α-helix	231-235	5
α-helix	237-241	5
β-strand	270-272	3	47
β-strand	276-287	12	45
β-strand	292	1	48
β-strand	298	1	48
β-strand	320	1	49
β-strand	324	1	49
β-strand	330-334	5	45
β-strand	344-349	6	45
β-strand	365-368	4	45
α-helix	382-389	8
α-helix	393-401	9

Chain Lc: 4 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	10-21	12
β-strand	26-29	4	50
α-helix	31-39	9
β-strand	45-48	4	50
α-helix	54-67	14
β-strand	70-72	3	50
α-helix	78-84	7
β-strand	93-98	6	50

71 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
28S rRNA	L5	RNA	5070	Homo sapiens
5S rRNA	L7	RNA	121	Homo sapiens
5.8S rRNA	L8	RNA	157	Homo sapiens
60S ribosomal protein L8	LA	protein	257	Homo sapiens	P62917 (AlphaFold model)
60S ribosomal protein L3	LB	protein	403	Homo sapiens	P39023 (AlphaFold model)
60S ribosomal protein L4	LC	protein	427	Homo sapiens	P36578 (AlphaFold model)
60S ribosomal protein L5	LD	protein	297	Homo sapiens	P46777 (AlphaFold model)
60S ribosomal protein L6	LE	protein	288	Homo sapiens	Q02878
60S ribosomal protein L7	LF	protein	248	Homo sapiens	P18124
60S ribosomal protein L7a	LG	protein	266	Homo sapiens	P62424
60S ribosomal protein L9	LH	protein	192	Homo sapiens	P32969
60S ribosomal protein L10-like	LI	protein	214	Homo sapiens	Q96L21

72 more molecules are not listed.

Sequence of entity 1 (L5), FASTA

>6Z6M_1 28S rRNA (chains L5)
CGCGACCUCAGAUCAGACGUGGCGACCCGCUGAAUUUAAGCAUAUUAGUCAGCGGAGGAG
AAGAAACUAACCAGGAUUCCCUCAGUAACGGCGAGUGAACAGGGAAGAGCCCAGCGCCGA
AUCCCCGCCCCGCGGCGGGGCGCGGGACAUGUGGCGUACGGAAGACCCGCUCCCCGGCGC
CGCUCGUGGGGGGCCCAAGUCCUUCUGAUCGAGGCCCAGCCCGUGGACGGUGUGAGGCCG
GUAGCGGCCCCCGGCGCGCCGGGCCCGGGUCUUCCCGGAGUCGGGUUGCUUGGGAAUGCA
GCCCAAAGCGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGGCACGAGACCGAUAGUCAA
CAAGUACCGUAAGGGAAAGUUGAAAAGAACUUUGAAGAGAGAGUUCAAGAGGGCGUGAAA
CCGUUAAGAGGUAAACGGGUGGGGUCCGCGCAGUCCGCCCGGAGGAUUCAACCCGGCGGC
GGGUCCGGCCGUGUCGGCGGCCCGGCGGAUCUUUCCCGCCCCCCGUUCCUCCCGACCCCU
CCACCCGCCCUCCCUUCCCCCGCCGCCCCUCCUCCUCCUCCCCGGAGGGGGCGGGCUCCG
GCGGGUGCGGGGGUGGGCGGGCGGGGCCGGGGGUGGGGUCGGCGGGGGACCGUCCCCCGA
CCGGCGACCGGCCGCCGCCGGGCGCAUUUCCACCGCGGCGGUGCGCCGCGACCGGCUCCG
GGACGGCUGGGAAGGCCCGGCGGGGAAGGUGGCUCGGGGGGCCCCGUCCGUCCGUCCGUC
CGUCCUCCUCCUCCCCCGUCUCCGCCCCCCGGCCCCGCGUCCUCCCUCGGGAGGGCGCGC
GGGUCGGGGCGGCGGCGGCGGCGGCGGUGGCGGCGGCGGCGGCGGCGGCGGGACCGAAAC
CCCCCCCGAGUGUUACAGCCCCCCCGGCAGCAGCACUCGCCGAAUCCCGGGGCCGAGGGA
GCGAGACCCGUCGCCGCGCUCUCCCCCCUCCCGGCGCCCACCCCCGCGGGGAAUCCCCCG
CGAGGGGGGUCUCCCCCGCGGGGGCGCGCCGGCGUCUCCUCGUGGGGGGGCCGGGCCACC
CCUCCCACGGCGCGACCGCUCUCCCACCCCUCCUCCCCGCGCCCCCGCCCCGGCGACGGG
GGGGGUGCCGCGCGCGGGUCGGGGGGCGGGGCGGACUGUCCCCAGUGCGCCCCGGGCGGG
UCGCGCCGUCGGGCCCGGGGGAGGUUCUCUCGGGGCCACGCGCGCGUCCCCCGAAGAGGG
GGACGGCGGAGCGAGCGCACGGGGUCGGCGGCGACGUCGGCUACCCACCCGACCCGUCUU
GAAACACGGACCAAGGAGUCUAACACGUGCGCGAGUCGGGGGCUCGCACGAAAGCCGCCG
UGGCGCAAUGAAGGUGAAGGCCGGCGCGCUCGCCGGCCGAGGUGGGAUCCCGAGGCCUCU
CCAGUCCGCCGAGGGCGCACCACCGGCCCGUCUCGCCCGCCGCGCCGGGGAGGUGGAGCA
CGAGCGCACGUGUUAGGACCCGAAAGAUGGUGAACUAUGCCUGGGCAGGGCGAAGCCAGA
GGAAACUCUGGUGGAGGUCCGUAGCGGUCCUGACGUGCAAAUCGGUCGUCCGACCUGGGU
AUAGGGGCGAAAGACUAAUCGAACCAUCUAGUAGCUGGUUCCCUCCGAAGUUUCCCUCAG
GAUAGCUGGCGCUCUCGCAGACCCGACGCACCCCCGCCACGCAGUUUUAUCCGGUAAAGC
GAAUGAUUAGAGGUCUUGGGGCCGAAACGAUCUCAACCUAUUCUCAAACUUUAAAUGGGU
AAGAAGCCCGGCUCGCUGGCGUGGAGCCGGGCGUGGAAUGCGAGUGCCUAGUGGGCCACU
UUUGGUAAGCAGAACUGGCGCUGCGGGAUGAACCGAACGCCGGGUUAAGGCGCCCGAUGC
CGACGCUCAUCAGACCCCAGAAAAGGUGUUGGUUGAUAUAGACAGCAGGACGGUGGCCAU
GGAAGUCGGAAUCCGCUAAGGAGUGUGUAACAACUCACCUGCCGAAUCAACUAGCCCUGA
AAAUGGAUGGCGCUGGAGCGUCGGGCCCAUACCCGGCCGUCGCCGGCAGUCGAGAGUGGA
CGGGAGCGGCGGCGGCGGCGCGCGCGCGCGCGCGUGUGGUGUGCGUCGGAGGGCGGCGGC
GGCGGCGGCGGCGGGGGUGUGGGGUCCUUCCCCCGCCCCCCCCCCCACGCCUCCUCCCCU
CCUCCCGCCCACGCCCCGCUCCCCGCCCCCGGAGCCCCGCGGACGCUACGCCGCGACGAG
UAGGAGGGCCGCUGCGGUGAGCCUUGAAGCCUAGGGCGCGGGCCCGGGUGGAGCCGCCGC
AGGUGCAGAUCUUGGUGGUAGUAGCAAAUAUUCAAACGAGAACUUUGAAGGCCGAAGUGG
AGAAGGGUUCCAUGUGAACAGCAGUUGAACAUGGGUCAGUCGGUCCUGAGAGAUGGGCGA
GCGCCGUUCCGAAGGGACGGGCGAUGGCCUCCGUUGCCCUCGGCCGAUCGAAAGGGAGUC
GGGUUCAGAUCCCCGAAUCCGGAGUGGCGGAGAUGGGCGCCGCGAGGCGUCCAGUGCGGU
AACGCGACCGAUCCCGGAGAAGCCGGCGGGAGCCCCGGGGAGAGUUCUCUUUUCUUUGUG
AAGGGCAGGGCGCCCUGGAAUGGGUUCGCCCCGAGAGAGGGGCCCGUGCCUUGGAAAGCG
UCGCGGUUCCGGCGGCGUCCGGUGAGCUCUCGCUGGCCCUUGAAAAUCCGGGGGAGAGGG
UGUAAAUCUCGCGCCGGGCCGUACCCAUAUCCGCAGCAGGUCUCCAAGGUGAACAGCCUC
UGGCAUGUUGGAACAAUGUAGGUAAGGGAAGUCGGCAAGCCGGAUCCGUAACUUCGGGAU
AAGGAUUGGCUCUAAGGGCUGGGUCGGUCGGGCUGGGGCGCGAAGCGGGGCUGGGCGCGC
GCCGCGGCUGGACGAGGCGCCGCCGCCCCCCCCACGCCCGGGGCACCCCCCUCGCGGCCC
UCCCCCGCCCCACCCCGCGCGCGCCGCUCGCUCCCUCCCCGCCCCGCGCCCUCUCUCUCU
CUCUCUCCCCCGCUCCCCGUCCUCCCCCCUCCCCGGGGGAGCGCCGCGUGGGGGCGGCGG
CGGGGGGAGAAGGGUCGGGGCGGCAGGGGCCGGCGGCGGCCCGCCGCGGGGCCCCGGCGG
CGGGGGCACGGUCCCCCGCGAGGGGGGCCCGGGCACCCGGGGGGCCGGCGGCGGCGGCGA
CUCUGGACGCGAGCCGGGCCCUUCCCGUGGAUCGCCCCAGCUGCGGCGGGCGUCGCGGCC
GCCCCCGGGGAGCCCGGCGGGCGCCGGCGCGCCCCCCCCCCCACCCCACGUCUCGUCGCG
CGCGCGUCCGCUGGGGGCGGGGAGCGGUCGGGCGGCGGCGGUCGGCGGGCGGCGGGGCGG
GGCGGUUCGUCCCCCCGCCCUACCCCCCCGGCCCCGUCCGCCCCCCGUUCCCCCCUCCUC
CUCGGCGCGCGGCGGCGGCGGCGGCAGGCGGCGGAGGGGCCGCGGGCCGGUCCCCCCCGC
CGGGUCCGCCCCCGGGGCCGCGGUUCCGCGCGGCGCCUCGCCUCGGCCGGCGCCUAGCAG
CCGACUUAGAACUGGUGCGGACCAGGGGAAUCCGACUGUUUAAUUAAAACAAAGCAUCGC
GAAGGCCCGCGGCGGGUGUUGACGCGAUGUGAUUUCUGCCCAGUGCUCUGAAUGUCAAAG
UGAAGAAAUUCAAUGAAGCGCGGGUAAACGGCGGGAGUAACUAUGACUCUCUUAAGGUAG
CCAAAUGCCUCGUCAUCUAAUUAGUGACGCGCAUGAAUGGAUGAACGAGAUUCCCACUGU
CCCUACCUACUAUCCAGCGAAACCACAGCCAAGGGAACGGGCUUGGCGGAAUCAGCGGGG
AAAGAAGACCCUGUUGAGCUUGACUCUAGUCUGGCACGGUGAAGAGACAUGAGAGGUGUA
GAAUAAGUGGGAGGCCCCCGGCGCCCCCCCGGUGUCCCCGCGAGGGGCCCGGGGCGGGGU
CCGCCGGCCCUGCGGGCCGCCGGUGAAAUACCACUACUCUGAUCGUUUUUUCACUGACCC
GGUGAGGCGGGGGGGCGAGCCCCGAGGGGCUCUCGCUUCUGGCGCCAAGCGCCCGGCCGC
GCGCCGGCCGGGCGCGACCCGCUCCGGGGACAGUGCCAGGUGGGGAGUUUGACUGGGGCG
GUACACCUGUCAAACGGUAACGCAGGUGUCCUAAGGCGAGCUCAGGGAGGACAGAAACCU
CCCGUGGAGCAGAAGGGCAAAAGCUCGCUUGAUCUUGAUUUUCAGUACGAAUACAGACCG
UGAAAGCGGGGCCUCACGAUCCUUCUGACCUUUUGGGUUUUAAGCAGGAGGUGUCAGAAA
AGUUACCACAGGGAUAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUG
AUCCUUCGAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGU
UCACCCACUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUAC
CCUACUGAUGAUGUGUUGUUGCCAUGGUAAUCCUGCUCAGUACGAGAGGAACCGCAGGUU
CAGACAUUUGGUGUAUGUGCUUGGCUGAGGAGCCAAUGGGGCGAAGCUACCAUCUGUGGG
AUUAUGACUGAACGCCUCUAAGUCAGAAUCCCGCCCAGGCGGAACGAUACGGCAGCGCCG
CGGAGCCUCGGUUGGCCUCGGAUAGCCGGUCCCCCGCCUGUCCCCGCCGGCGGGCCGCCC
CCCCCCUCCACGCGCCCCGCGCGCGCGGGAGGGCGCGUGCCCCGCCGCGCGCCGGGACCG
GGGUCCGGUGCGGAGUGCCCUUCGUCCUGGGAAACGGGGCGCGGCCGGAGAGGCGGCCGC
CCCCUCGCCCGUCACGCACCGCACGUUCGUGGGGAACCUGGCGCUAAACCAUUCGUAGAC
GACCUGCUUCUGGGUCGGGG

Sequence of entity 2 (L7), FASTA

>6Z6M_2 5S rRNA (chains L7)
GUCUACGGCCAUACCACCCUGAACGCGCCCGAUCUCGUCUGAUCUCGGAAGCUAAGCAGG
GUCGGGCCUGGUUAGUACUUGGAUGGGAGACCGCCUGGGAAUACCGGGUGCUGUAGGCUU
U

Sequence of entity 3 (L8), FASTA

>6Z6M_3 5.8S rRNA (chains L8)
CGACUCUUAGCGGUGGAUCACUCGGCUCGUGCGUCGAUGAAGAACGCAGCUAGCUGCGAG
AAUUAAUGUGAAUUGCAGGACACAUUGAUCAUCGACACUUCGAACGCACUUGCGGCCCCG
GGUUCCUCCCGGGGCUACGCCUGUCUGAGCGUCGCUU

Sequence of entity 4 (LA), FASTA

>6Z6M_4 60S ribosomal protein L8 (chains LA)
MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAK
VVFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKP
GDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPIL
KAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAA
RRTGRLRGTKTVQEKEN

Sequence of entity 5 (LB), FASTA

>6Z6M_5 60S ribosomal protein L3 (chains LB)
MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREV
DRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYK
NWHKSKKKAFTKYCKKWQDEDGKKQLEKDFSSMKKYCQVIRVIAHTQMRLLPLRQKKAHL
MEIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKL
PRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIK
NNASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSLLVQTKRRAL
EKIDLKFIDTTSKFGHGRFQTMEEKKAFMGPLKKDRIAKEEGA

Sequence of entity 6 (LC), FASTA

>6Z6M_6 60S ribosomal protein L4 (chains LC)
MACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGH
QTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQK
RYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAWNDI
KKVYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKL
APGGHVGRFCIWTESAFRKLDELYGTWRKAASLKSNYNLPMHKMINTDLSRILKSPEIQR
ALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVDKAAAAAAA
LQAKSDEKAAVAGKKPVVGKKGKKAAVGVKKQKKPLVGKKAAATKKPAPEKKPAEKKPTT
EEKKPAA

Sequence of entity 7 (LD), FASTA

>6Z6M_7 60S ribosomal protein L5 (chains LD)
MGFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDI
ICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYE
GQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRF
PGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMY
KKAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES

Sequence of entity 8 (LE), FASTA

>6Z6M_8 60S ribosomal protein L6 (chains LE)
MAGEKVEKPDTKEKKPEAKKVDAGGKVKKGNLKAKKPKKGKPHCSRNPVLVRGIGRYSRS
AMYSRKAMYKRKYSAAKSKVEKKKKEKVLATVTKPVGGDKNGGTRVVKLRKMPRYYPTED
VPRKLLSHGKKPFSQHVRKLRASITPGTILIILTGRHRGKRVVFLKQLASGLLLVTGPLV
LNRVPLRRTHQKFVIATSTKIDISNVKIPKHLTDAYFKKKKLRKPRHQEGEIFDTEKEKY
EITEQRKIDQKAVDSQILPKIKAIPQLQGYLRSVFALTNGIYPHKLVF

Sequence of entity 9 (LF), FASTA

>6Z6M_9 60S ribosomal protein L7 (chains LF)
MEGVEEKKKEVPAVPETLKKKRRNFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKE
YRQMYRTEIRMARMARKAGNFYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNG
TFVKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNALIARSLG
KYGIICMEDLIHEIYTVGKRFKEANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQI
NRLIRRMN

Sequence of entity 10 (LG), FASTA

>6Z6M_10 60S ribosomal protein L7a (chains LG)
MPKGKKAKGKKVAPAPAVVKKQEAKKVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRY
IRLQRQRAILYKRLKVPPAINQFTQALDRQTATQLLKLAHKYRPETKQEKKQRLLARAEK
KAAGKGDVPTKRPPVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVP
YCIIKGKARLGRLVHRKTCTTVAFTQVNSEDKGALAKLVEAIRTNYNDRYDEIRRHWGGN
VLGPKSVARIAKLEKAKAKELATKLG

Sequence of entity 11 (LH), FASTA

>6Z6M_11 60S ribosomal protein L9 (chains LH)
MKTILSNQTVDIPENVDITLKGRTVIVKGPRGTLRRDFNHINVELSLLGKKKKRLRVDKW
WGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQENGSLVEIRNFLGE
KYIRRVRMRPGVACSVSQAQKDELILEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIY
VSEKGTVQQADE

Sequence of entity 12 (LI), FASTA

>6Z6M_12 60S ribosomal protein L10-like (chains LI)
MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLGGHMVSDEYEQL
SSEALEAARICANKYMVKSCGRDGFHMRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFG
KPQGTVARVHIGQVIMSIRTKLQNEEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADE
FEDMVAKKCLIPDGCGVKYVPSHGPLDKWRVLHS

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	8
MG	Magnesium ion	Mg	256

Primary citation

Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes. Wells, J.N., Buschauer, R., Mackens-Kiani, T. et al. PLoS Biol (2020) 18:e3000780-e3000780. DOI 10.1371/journal.pbio.3000780 · PubMed

Other PDB entries of the same protein (UniProt P62917 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8A3D 1.67 Å, Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound
29IW 1.77 Å, Human monosomes with bound toxin NT-2, focus on 60S subunit. Cells treated with NT-2.
8QYX 1.78 Å, Human 60S ribosomal subunit
8QOI 1.9 Å, Structure of the human 80S ribosome at 1.9 A resolution - the molecular role of chemical…
9O3W 1.9 Å, Human 80S ribosome bound to IDB-001 stalled on MYC nascent chain
8YOO 2.0 Å, Cryo-EM structure of the human 80S ribosome with 100 um Tigecycline
9C3H 2.0 Å, Structure of the CNOT3-bound human 80S ribosome with tRNA-ARG in the P-site.
29IZ 2.08 Å, Dormant 80S:eEF2:SERBP1:tRNA complex from human cells treated with toxin NT-2
9TV2 2.1 Å, 80S ribosomes from primary B-cells infected with delta v-snoRNA1 EBV
9I2D 2.19 Å, NMT1-NAC bound human RNC with 10 amino acid ARF1-linker
9PBE 2.19 Å, In situ human 80S ribosome (composite map)
29IX 2.2 Å, Human monosomes with bound toxin NT-2, focus on 60S subunit. NT-2 added to purified…

Browse structure collections

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